Results 11 to 20 of about 442,921 (391)
Definitions, 2020 NADPH oxidase 4 (578 aa, ~67 kDa) is encoded by the human NOX4 gene. This protein plays a role as an oxygen sensor in cell differentiation and signal transduction.
semanticscholar +2 more sources
NADPH oxidase limits innate immune responses in the lungs in mice. [PDF]
PLoS ONE, 2010 Chronic granulomatous disease (CGD), an inherited disorder of the NADPH oxidase in which phagocytes are defective in generating superoxide anion and downstream reactive oxidant intermediates (ROIs), is characterized by recurrent bacterial and fungal ...
Brahm H Segal +20 more
doaj +1 more source
Myeloid-derived suppressor cells modulate immune responses independently of NADPH oxidase in the ovarian tumor microenvironment in mice. [PDF]
PLoS ONE, 2013 The phagocyte NADPH oxidase generates superoxide anion and downstream reactive oxidant intermediates in response to infectious threat, and is a critical mediator of antimicrobial host defense and inflammatory responses.
Heidi E Godoy +10 more
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Role of NADPH oxidase versus neutrophil proteases in antimicrobial host defense. [PDF]
PLoS ONE, 2011 NADPH oxidase is a crucial enzyme in mediating antimicrobial host defense and in regulating inflammation. Patients with chronic granulomatous disease, an inherited disorder of NADPH oxidase in which phagocytes are defective in generation of reactive ...
R Robert Vethanayagam +10 more
doaj +1 more source
Antioxidants, 2021 Background: Formyl peptide receptor 2 (FPR2) is involved in the pathogenesis of chronic inflammatory diseases, being activated either by pro-resolving or proinflammatory ligands.
Rosario Ammendola +3 more
doaj +1 more source
Neurobiology of Disease, 2008 Background: Inflammation and reactive oxygen species (ROS) are important in the development of perinatal brain injury. The ROS-generating enzyme NADPH oxidase (Nox2) is present in inflammatory cells and contributes to brain injury in adult animal models.
Christina Doverhag +12 more
doaj +1 more source
Skeletal muscle NADPH oxidase is increased and triggers stretch-induced damage in the mdx mouse. [PDF]
PLoS ONE, 2010 Recent studies have shown that oxidative stress contributes to the pathogenesis of muscle damage in dystrophic (mdx) mice. In this study we have investigated the role of NADPH oxidase as a source of the oxidative stress in these mice.
Nicholas P Whitehead +3 more
doaj +1 more source
NADPH oxidase as a therapeutic target in Alzheimer\u27s disease [PDF]
, 2008 At present, available treatments for Alzheimer\u27s disease (AD) are largely unable to halt disease progression. Microglia, the resident macrophages in the brain, are strongly implicated in the pathology and progressively degenerative nature of AD ...
Block, Michelle L
core +4 more sources
NADPH Oxidase and Neurodegeneration [PDF]
Current Neuropharmacology, 2012 NADPH oxidase (Nox) is a unique, multi-protein, electron transport system that produces large amounts of superoxide via the reduction of molecular oxygen. Nox-derived reactive oxygen species (ROS) are known to be involved in a variety of physiological processes, including host defense and signal transduction.
Hernandes, Marina S, Britto, Luiz R G
openaire +2 more sources
A role for NADPH oxidase in antigen presentation
Frontiers in Immunology, 2013 The nicotinamide adenine dinucleotide phosphate (NADPH) oxidase expressed in phagocytes is a multi-subunit enzyme complex that generates superoxide (O2.-).
Gail J Gardiner +5 more
doaj +1 more source