Results 11 to 20 of about 424,484 (404)
A Role for NADPH Oxidase in Antigen Presentation [PDF]
Frontiers in Immunology, 2013 The nicotinamide adenine dinucleotide phosphate (NADPH) oxidase expressed in phagocytes is a multi-subunit enzyme complex that generates superoxide (O2 (.-)). This radical is an important precursor of hydrogen peroxide (H2O2) and other reactive oxygen species needed for microbicidal activity during innate immune responses.
Shawna McLetchie +5 more
openaire +4 more sources
eLife, 2017 Transient increases in mitochondrially-derived reactive oxygen species (ROS) activate an adaptive stress response to promote longevity. Nicotinamide adenine dinucleotide phosphate (NADPH) oxidases produce ROS locally in response to various stimuli, and ...
Collin Yvès Ewald +8 more
doaj +2 more sources
NADPH oxidase-dependent production of reactive oxygen species induces endoplasmatic reticulum stress in neutrophil-like HL60 cells. [PDF]
PLoS ONE, 2015 Reactive oxygen species (ROS) primarily produced via NADPH oxidase play an important role for killing microorganisms in neutrophils. In this study we examined if ROS production in Human promyelocytic leukemia cells (HL60) differentiated into neutrophil ...
Wilson Mitsuo Tatagiba Kuwabara +5 more
doaj +2 more sources
The NADPH Oxidase of Endothelial Cells [PDF]
IUBMB Life, 2000 AbstractThe best known NADPH oxidase is that of phagocytes‐ neutrophils and monocytes. In these cells, the enzyme manufactures large quantities of O2 ‐ and other reactive oxidants that are used for the purpose of killing invading microorganisms. Recent studies, however, have suggested that a number of other tissues contain NADPH oxidases.
Bernard Babior
openaire +5 more sources
ROS Signaling and NADPH Oxidase in Red Algae. [PDF]
Antioxidants (Basel)We explore the diverse roles of reactive oxygen species (ROS) and NADPH oxidases in red algae, focusing on their involvement in fertilization, wound repair, stress adaptation, and development.
Kim GH, Shim E, Zuccarello GC.
europepmc +2 more sources
Oxidative Medicine and Cellular Longevity, 2021 NADPH oxidase as an important source of intracellular reactive oxygen species (ROS) has gained enormous importance over the years, and the detailed structures of all the isoenzymes of the NADPH oxidase family and their regulation have been well explored.
Upasana Ganguly +6 more
semanticscholar +1 more source
NADPH Oxidase and Neurodegeneration [PDF]
Current Neuropharmacology, 2012 NADPH oxidase (Nox) is a unique, multi-protein, electron transport system that produces large amounts of superoxide via the reduction of molecular oxygen. Nox-derived reactive oxygen species (ROS) are known to be involved in a variety of physiological processes, including host defense and signal transduction.
Marina S. Hernandes, Luiz R.G. Britto
openaire +2 more sources
NADPH oxidase limits innate immune responses in the lungs in mice. [PDF]
PLoS ONE, 2010 Chronic granulomatous disease (CGD), an inherited disorder of the NADPH oxidase in which phagocytes are defective in generating superoxide anion and downstream reactive oxidant intermediates (ROIs), is characterized by recurrent bacterial and fungal ...
Brahm H Segal +20 more
doaj +1 more source
NADPH Oxidases and Their Role in Atherosclerosis [PDF]
Biomedicines, 2020 The current view on atherosclerosis positions it as a multifactorial disorder that results from the interplay between lipid metabolism disturbances and inflammatory processes. Oxidative stress is proven to be one of the initiating factors in atherosclerosis development, being implicated both in the inflammatory response and in atherogenic modifications
Anastasia V. Poznyak +5 more
openaire +4 more sources
Myeloid-derived suppressor cells modulate immune responses independently of NADPH oxidase in the ovarian tumor microenvironment in mice. [PDF]
PLoS ONE, 2013 The phagocyte NADPH oxidase generates superoxide anion and downstream reactive oxidant intermediates in response to infectious threat, and is a critical mediator of antimicrobial host defense and inflammatory responses.
Heidi E Godoy +10 more
doaj +1 more source