Results 31 to 40 of about 424,484 (404)
Journal of Clinical Investigation, 1996 We tested the hypothesis that angiotensin II-induced hypertension is associated with an increase in vascular .O2- production, and characterized the oxidase involved in this process.
S. Rajagopalan +6 more
semanticscholar +1 more source
Acta Societatis Botanicorum Poloniae, 2017 Cadmium-induced oxidative burst is partially mediated by NADPH oxidase. The aim of the present research was to evaluate the role of NADPH oxidase in soybeans’ response to short-term cadmium stress.
Jagna Chmielowska-Bąk +6 more
doaj +1 more source
Definitions, 2020 NADPH oxidase 4 (578 aa, ~67 kDa) is encoded by the human NOX4 gene. This protein plays a role as an oxygen sensor in cell differentiation and signal transduction.
semanticscholar +1 more source
NADPH Oxidases in Vascular Pathology [PDF]
Antioxidants & Redox Signaling, 2014 Reactive oxygen species (ROS) play a critical role in vascular disease. While there are many possible sources of ROS, nicotinamide adenine dinucleotide phosphate (NADPH) oxidases play a central role. They are a source of "kindling radicals," which affect other enzymes, such as nitric oxide synthase endothelial nitric oxide synthase or xanthine oxidase.
Tomasz J. Guzik +3 more
openaire +3 more sources
NADPH Oxidase 1 Is Associated with Altered Host Survival and T Cell Phenotypes after Influenza A Virus Infection in Mice. [PDF]
PLoS ONE, 2016 The role of the reactive oxygen species-producing NADPH oxidase family of enzymes in the pathology of influenza A virus infection remains enigmatic. Previous reports implicated NADPH oxidase 2 in influenza A virus-induced inflammation. In contrast, NADPH
Amelia R Hofstetter +16 more
doaj +1 more source
The NAD(P)H:flavin oxidoreductase from Escherichia coli. Evidence for a new mode of binding for reduced pyridine nucleotides [PDF]
The journal of biological chemistry, American Society for
Biochemistry and Molecular Biology, 1999, 274, pp.18252-60, 2015 The NAD(P)H:flavin oxidoreductase from Escherichia coli, named Fre, is a monomer of 26.2 kDa that catalyzes the reduction of free flavins using NADPH or NADH as electron donor. The enzyme does not contain any prosthetic group but accommodates both the reduced pyridine nucleotide and the flavin in a ternary complex prior to oxidoreduction.
arxiv +1 more source
Phosphatidylinositol 3-kinase plays a vital role in regulation of rice seed vigor via altering NADPH oxidase activity. [PDF]
PLoS ONE, 2012 Phosphatidylinositol 3-kinase (PI3K) has been reported to be important in normal plant growth and stress responses. In this study, it was verified that PI3K played a vital role in rice seed germination through regulating NADPH oxidase activity ...
Jian Liu, Jun Zhou, Da Xing
doaj +1 more source
Neutrophils to the ROScue: Mechanisms of NADPH Oxidase Activation and Bacterial Resistance
Frontiers in Cellular and Infection Microbiology, 2017 Reactive oxygen species (ROS) generated by NADPH oxidase play an important role in antimicrobial host defense and inflammation. Their deficiency in humans results in recurrent and severe bacterial infections, while their unregulated release leads to ...
G. T. Nguyen, Erin R Green, J. Mecsas
semanticscholar +1 more source
Journal of Ophthalmology, 2010 Objectives. Using apocynin (inhibitor of NADPH oxidase), and Mitoquinol 10 nitrate (MitoQ; mitochondrial-targeted antioxidant), we addressed the importance of mitochondria versus NADPH oxidase-derived ROS in glucose-induced apoptosis of pericytes ...
Nik M. Mustapha +3 more
doaj +1 more source
The roles of NADPH oxidase in modulating neutrophil effector responses
Molecular Oral Microbiology, 2019 Neutrophils are phagocytic innate immune cells essential for killing bacteria via activation of a wide variety of effector responses and generation of large amounts of reactive oxygen species (ROS).
M. Zeng +4 more
semanticscholar +1 more source