Redox Biology, 2017 Histone deacetylase 6 (HDAC6) likely is important in inflammatory diseases. However, how HDAC6 exerts its effect on inflammatory processes remains unclear.
Gi Soo Youn +4 more
doaj +1 more source
Neutrophils to the ROScue: Mechanisms of NADPH Oxidase Activation and Bacterial Resistance
Frontiers in Cellular and Infection Microbiology, 2017 Reactive oxygen species (ROS) generated by NADPH oxidase play an important role in antimicrobial host defense and inflammation. Their deficiency in humans results in recurrent and severe bacterial infections, while their unregulated release leads to ...
G. T. Nguyen, Erin R Green, J. Mecsas
semanticscholar +1 more source
NADPH oxidase and enhanced superoxide generation in intrauterine undernourished rats: involvement of the renin-angiotensin system [PDF]
, 2003 Objective: We previously reported that intrauterine undernutrition increased the oxidative stress by decreasing superoxide dismutase activity. in the present study, we tested whether NADPH oxidase, xanthine oxidase, cyclooxygenase or nitric oxide ...
Akamine, E. H. +6 more
core +1 more source
Acute oxygen sensing: diverse but convergent mechanisms in airway and arterial chemoreceptors [PDF]
, 2001 Airway neuroepithelial bodies sense changes in inspired O2, whereas arterial O2 levels are monitored primarily by the carotid body. Both respond to hypoxia by initiating corrective cardiorespiratory reflexes, thereby optimising gas exchange in the face ...
Kemp, P.J., Peers, C.
core +4 more sources
The roles of NADPH oxidase in modulating neutrophil effector responses
Molecular Oral Microbiology, 2019 Neutrophils are phagocytic innate immune cells essential for killing bacteria via activation of a wide variety of effector responses and generation of large amounts of reactive oxygen species (ROS).
M. Zeng +4 more
semanticscholar +1 more source
Nox2 dependent redox-regulation of microglial response to amyloid-β stimulation and microgliosis in aging [PDF]
, 2020 Microglia express constitutively a Nox2 enzyme that is involved in neuroinflammation by the generation of reactive oxygen species (ROS). Amyloid β (Aβ) plays a crucial role in Alzheimer’s disease.
Fan, Lampson M. +4 more
core +2 more sources
NADPH Oxidases in Pain Processing
Antioxidants, 2022 Inflammation or injury to the somatosensory nervous system may result in chronic pain conditions, which affect millions of people and often cause major health problems. Emerging lines of evidence indicate that reactive oxygen species (ROS), such as superoxide anion or hydrogen peroxide, are produced in the nociceptive system during chronic inflammatory
Wiebke Kallenborn-Gerhardt +2 more
openaire +4 more sources
Annexin peptide Ac2-26 suppresses TNFα-induced inflammatory responses via inhibition of Rac1-dependent NADPH oxidase in human endothelial cells. [PDF]
PLoS ONE, 2013 The anti-inflammatory peptide annexin-1 binds to formyl peptide receptors (FPR) but little is known about its mechanism of action in the vasculature. Here we investigate the effect of annexin peptide Ac2-26 on NADPH oxidase activity induced by tumour ...
Hitesh M Peshavariya +6 more
doaj +1 more source
The Role of NADPH Oxidase in Neuronal Death and Neurogenesis after Acute Neurological Disorders
Antioxidants, 2021 Oxidative stress is a well-known common pathological process involved in mediating acute neurological injuries, such as stroke, traumatic brain injury, epilepsy, and hypoglycemia-related neuronal injury.
Song Hee Lee +4 more
doaj +1 more source
NADPH oxidase in brain injury and neurodegenerative disorders
Molecular Neurodegeneration, 2017 Oxidative stress is a common denominator in the pathology of neurodegenerative disorders such as Alzheimer’s disease, Parkinson’s disease, Huntington’s disease, amyotrophic lateral sclerosis, and multiple sclerosis, as well as in ischemic and traumatic ...
Merry W. Ma +6 more
semanticscholar +1 more source