Results 61 to 70 of about 424,484 (404)
Exercise Training Ameliorates Renal Oxidative Stress in Rats with Chronic Renal Failure
Metabolites, 2022 In patients with chronic kidney disease, exercise training with moderate intensity protects renal function and improves mortality. However, the mechanisms of the renal protective effects of exercise training in chronic kidney disease have not been ...
Seiko Yamakoshi +4 more
doaj +1 more source
Portosystemic hepatic encephalopathy model shows reversal learning impairment and dysfunction of neural activity in the prefrontal cortex and regions involved in motivated behavior [PDF]
Journal of Clinical Neuroscience (2011)18(5):690-4, 2011 Hepatic encephalopathy is a neurological complication that affects attention and memory. Experimental animal models have been used to study hepatic Encephalopathy, the most frequent being the portacaval shunt. In order to determine learning impairment and brain functional alterations in this model, we assessed reversal learning and neural metabolic ...
arxiv +1 more source
Inhibition of spontaneous neutrophil apoptosis by parabutoporin acts independently of NADPH oxidase inhibition but by lipid raft-dependent stimulation of Akt [PDF]
, 2008 Neutrophil cell death plays a crucial role in neutrophil homeostasis and the resolution of inflammation. The superoxide-producing NADPH oxidase is involved in pathogen degradation and subsequent activation of cell death programs.
Asselbergh, Bob +5 more
core +2 more sources
Neural Regeneration ResearchParkinson’s disease is primarily caused by the loss of dopaminergic neurons in the substantia nigra compacta. Ferroptosis, a novel form of regulated cell death characterized by iron accumulation and lipid peroxidation, plays a vital role in the death of ...
Zhihao Lin +8 more
doaj +1 more source
Regulation of the NADPH Oxidase RBOHD During Plant Immunity.
Plant and Cell Physiology, 2015 Pathogen recognition induces the production of reactive oxygen species (ROS) by NADPH oxidases in both plants and animals. ROS have direct antimicrobial properties, but also serve as signaling molecules to activate further immune outputs.
Y. Kadota, K. Shirasu, C. Zipfel
semanticscholar +1 more source
NADPH Oxidase and Cardiac Failure [PDF]
Journal of Cardiovascular Translational Research, 2010 Increases in oxidative stress in the heart play an important role in mediating hypertrophy, apoptosis, fibrosis, mitochondrial dysfunction, and the consequent development of heart failure. Although it has been widely believed that electron leakage from the mitochondrial electron transport chain is the primary source of oxidative stress in the failing ...
Junichi Sadoshima, Junya Kuroda
openaire +3 more sources
Extended Linear Response for Bioanalytical Applications Using Multiple Enzymes [PDF]
Analyt. Chem. 85, 2027-2031 (2013), 2013 We develop a framework for optimizing a novel approach to extending the linear range of bioanalytical systems and biosensors by utilizing two enzymes with different kinetic responses to the input chemical as their substrate. Data for the flow-injection amperometric system devised for detection of lysine based on the function of L-Lysine-alpha-Oxidase ...
arxiv +1 more source
Acute oxygen sensing: diverse but convergent mechanisms in airway and arterial chemoreceptors [PDF]
, 2001 Airway neuroepithelial bodies sense changes in inspired O2, whereas arterial O2 levels are monitored primarily by the carotid body. Both respond to hypoxia by initiating corrective cardiorespiratory reflexes, thereby optimising gas exchange in the face ...
Kemp, P.J., Peers, C.
core +4 more sources
Redox signaling, Nox5 and vascular remodeling in hypertension [PDF]
, 2015 Purpose of review: Extensive data indicate a role for reactive oxygen species (ROS) and redox signaling in vascular damage in hypertension. However, molecular mechanisms underlying these processes remain unclear, but oxidative post-translational ...
De Lucca Camargo, Livia +5 more
core +1 more source
NADPH Oxidases: Progress and Opportunities [PDF]
Antioxidants & Redox Signaling, 2014 From the initial discovery in 1999 that NADPH oxidases comprise a family of enzymes to our current focus on drug development to treat multiple pathologies related to this enzyme family, progress has been swift and impressive. We have expanded our understanding of the extent of the family, the basic enzymatic biochemistry, the multiple cellular ...
K GriendlingKathy, San MartinAlejandra
openaire +3 more sources