Results 111 to 120 of about 85,856,906 (279)

How and Why Cells Make Superoxide: The "Phagocytic" NADPH Oxidase

, 1995
The phagocyte enzyme NADPH oxidase generates superoxide essential for antimicrobial defense;its genetic defects cause the immunodeficiency disorder chronic granulomatous disease.
FE Maly, CC Schurer-Maly
core   +1 more source

Interactions between lactobacillus and yeast: A recent update

Food Biomacromolecules, EarlyView.
Abstract Lactobacillus and yeast are microorganisms widely distributed in nature. Their interactions significantly impact fermentation processes, human health, and medical care. However, there is a lack of a systematic summary of the characteristics of these interactions, and the mechanisms underlying these interactions remain unclear.
Yang Chen, Mengyuan Liu, Mengchen Li, Zhiyun Yue, Yang Mu, Chao Wang, Lusha Xia, Junjun Gao, Mingye Peng, Ran Wang, Mengzhou Zhou   +10 more
wiley   +1 more source

Metabolite Profiles and Antioxidant Activity of Dendrobium catenatum Under Simulated Wild Cultivation

Food Safety and Health, EarlyView.
Dendrobium catenatum grown under simulated wild cultivation showed significantly higher flavonoids and stilbenes, leading to enhanced antioxidant activity in both leaves and stems compared to facility‐grown plants. Integrated metabolomics, antioxidant assays, and network pharmacology identified Denbinobin as a key multi‐target antioxidant compound ...
Chuyun Guan, Yixin Tang, Qiaoxian Yu, Yanghui Shen, Ying Shi, Pan Wang, Jinping Si, Jingjing Liu   +7 more
wiley   +1 more source

NADPH oxidase 4 mediates TGF-β1/Smad signaling pathway induced acute kidney injury in hypoxia.

PLoS ONE, 2019
Hypoxia is an important cause of acute kidney injury (AKI) in various conditions because kidneys are one of the most susceptible organs to hypoxia. In this study, we investigated whether nicotinamide adenine dinucleotide 3-phosphate (NADPH) oxidase 4 ...
Sungkwon Cho, Seong-Lan Yu, Jaeku Kang, Bo Young Jeong, Hoi Young Lee, Chang Gyo Park, Young-Bin Yu, Dong-Chan Jin, Won-Min Hwang, Sung-Ro Yun, Ho Seung Song, Moon Hyang Park, Se-Hee Yoon   +12 more
doaj   +1 more source

Possible Role of NADPH Oxidase 4 in Angiotensin II-Induced Muscle Wasting in Mice

Frontiers in Physiology, 2018
Background: Muscle wasting is a debilitating phenotype associated with chronic heart failure (CHF). We have previously demonstrated that angiotensin II (AII) directly induces muscle wasting in mice through the activation of NADPH oxidase (Nox).
Tomoyasu Kadoguchi, Tomoyasu Kadoguchi, Kazunori Shimada, Kazunori Shimada, Hiroshi Koide, Tetsuro Miyazaki, Tomoyuki Shiozawa, Shuhei Takahashi, Tatsuro Aikawa, Shohei Ouchi, Kenichi Kitamura, Yurina Sugita, Al Shahi Hamad, Mitsuhiro Kunimoto, Yayoi Sato-Okabayashi, Koji Akita, Kikuo Isoda, Hiroyuki Daida, Hiroyuki Daida   +18 more
doaj   +1 more source

Current status of NADPH oxidase research in cardiovascular pharmacology

, 2013
Bruno K Rodiño-Janeiro,1,2 Beatriz Paradela-Dobarro,1 María Isabel Castiñeiras-Landeira,1 Sergio Raposeiras-Roubín,1,3 José R González-Juanatey,1,3,4 Ezequiel Álvarez1,4 1Health Research Institute of ...
González-Juanatey JR, Castiñeiras-Landeira MI, Raposeiras-Roubín S, Paradela-Dobarro B, Álvarez E, Rodiño-Janeiro BK   +5 more
core  

The Endothelial CXCR Family in Vascular Health and Disease

iNew Medicine, EarlyView.
ABSTRACT Endothelial cells (ECs) form the dynamic interface between blood and tissue, serving as key regulators of vascular homeostasis, inflammation, and repair. Among the molecular systems governing endothelial behavior, the C‐X‐C motif chemokine receptor (CXCR) family—originally characterized in immunology for its roles in leukocyte trafficking and ...
Zhiming Wu, Yandi Wu, Suowen Xu, Yu Huang, Li Wang   +4 more
wiley   +1 more source

Epigenetically Regulated NOX4/NRF2 Axis Mediates PM2.5‐Induced Ferroptosis and Inflammatory Response in Membranous Nephropathy

Journal of Applied Toxicology, EarlyView.
ABSTRACT This study aims to explore the involvement and mechanism of ferroptosis in particulate matter 2.5 (PM2.5)–induced membranous nephropathy (MN) progression. A cationic bovine serum albumin (cBSA)–induced mouse model of MN was established, followed by PM2.5 exposure.
Yanhong Gao, Yinfeng Guo, Shaoyan Xu, Min Zhang, Yanxia Rui, Shujun Pan, Changhua Zhou, Jianxiang Chen, Henglan Wu   +8 more
wiley   +1 more source

NOX4 serves as a pan-cancer prognostic biomarker and therapeutic target in tumorigenesis

Scientific Reports
NADPH oxidase 4 (NOX4) is a key regulator of intracellular reactive oxygen species (ROS) and plays a critical role in tumorigenesis and cancer progression.
Jiting Sun, Zhiyuan Gong, Lijie Zheng, Zhixian Ding, Lusheng Wang, Yu Tang, Shizhan Deng, Yonggan Dong, Heng Tang   +8 more
doaj   +1 more source

Mertk drives alveolar bone loss in experimental periodontitis associated with altered neutrophil function and osteoclast recruitment

Journal of Periodontology, EarlyView.
Abstract Background Alveolar bone loss is the hallmark of periodontitis and often remains refractory to conventional mechanical and antimicrobial therapies in chronic cases. Mer receptor tyrosine kinase (Mertk) has been implicated in bone homeostasis, yet the immune mechanisms by which Mertk modulates periodontal bone resorption remain insufficiently ...
Nicholas Mazzara, Kesley Martin, Rana Dabaja, Justin Redmond, Victoria Maglaras, Maxwell Mianecki, Harout Ashekian, Joseph T. Decker, Ann M. Decker   +8 more
wiley   +1 more source