Results 141 to 150 of about 85,856,906 (279)

Deficiency in the NADPH oxidase 4 predisposes towards diet-induced obesity

, 2012
NADPH oxidase 4 (NOX4) is a reactive oxygen species (ROS) producing NADPH oxidase that regulates redox homeostasis in diverse insulin-sensitive cell types.
Szanto, Ildiko, Montet, Xavier Cédric Rodolphe, D Pierroz, Hasler, Udo, S Ferrari, C Deffert, R Supale, F Negro, Supale, Radhika, X Montet, Feraille, Eric, I Szanto, Deffert, C, S Moll, Mouche, Sarah, Negro, Francesco, Meda, Paolo, Y Li, P Meda, T Sajic, C Veyrat-Durebex, K-H Krause, Veyrat-Durebex, Christelle, Ferrari, Serge Livio, E Feraille, Krause, Karl-Heinz, Li, Y, Pierroz Fuentes, Dominique, Sajic, Tatjana, S Mouche, Moll, Solange, U Hasler, Veyrat-Durebex C, Moll S, Meda P, Mouche S, Deffert C, Szanto I, Ferrari S, Feraille E, Krause KH, Pierroz D, Li Y, Negro F, Sajic T, Montet X, Hasler U, Supale R   +47 more
core   +1 more source

Toxicity Differences Between Microplastics and Nanoplastics in Organs: From Molecular Mechanisms to Potential Therapeutic Strategies

Med Research, EarlyView.
This review systematically compares the size‐dependent toxicity of microplastics and nanoplastics in the intestine, liver, kidney, lung, and brain. Particle size determines bioavailability, barrier penetration, and injury mechanisms. Because of their small size and high surface reactivity, NPs readily cross the intestinal epithelium and blood–brain ...
Yixian Cheng, Junjie Chen, Rui Fu, Jiawei Zhang, Jianguang Jia, Wei Wang, Zheng Zhang, Peng Zhang, Haosong Chen, Huake Cao, Gang Li, Weiwei Sheng, Ting Li, Bo Chen, Guodong Cao   +14 more
wiley   +1 more source

Studies on the NADPH oxidase of phagocytes. Production of a monoclonal antibody which blocks the enzymatic activity of pig neutrophil NADPH oxidase

, 1989
We describe in this paper a monoclonal antibody to pig NADPH oxidase which inhibits enzymatic activity. This antibody, designated 1H8.2, was selected from a group of monoclonal antibodies produced against active preparations of purified NADPH oxidase and
BERTON, Giorgio, DUSI, Stefano, ROSSI, Filippo, M. C. Serra, BELLAVITE, Paolo   +4 more
core   +1 more source

NADPH Oxidase 4 [PDF]

, 2020
openaire   +1 more source

trans Arachidonic acid isomers inhibit NADPH-oxidase activity by direct interaction with enzyme components

, 2012
NADPH-oxidase is an enzyme that represents, when activated, the major source of non-mitochondrial reactive oxygen species. In phagocytes, this production is an indispensable event for the destruction of engulfed pathogens.
Chatgilialoglu, C., Souabni, H., Ferreri, C., Houee Levin, Chantal, Bizouarn, Tania, Thoma, V., Baciou, Laura, Ostuni, Mariano A., Siafaka-Kapadai, A., Ferreri C, Chatgilialoglu C, Baciou L, SiafakaKapadai A, Bizouarn T, Souabni H, Thoma V, Ostuni M A, HoueeLevin C   +17 more
core   +1 more source

Chronic high‐altitude exposure and intracerebral hemorrhage: A novel perspective from the vascular‐immune‐neuronal network

Neuroprotection, EarlyView.
Long‐term chronic high‐altitude hypobaric hypoxia increases susceptibility to ICH, particularly among migrant populations lacking EPAS1/SENP1 adaptive genetic variants relative to high‐altitude indigenous residents. Persistent hypoxia initiates blood–brain barrier (BBB) breakdown, aberrant glial and immune activation, and progressive neuronal injury ...
Rongsu Huang, Linjie Wei, Mingxi Li, Bo Wu, Rongjian Ouyang, Gang Zhu, Yujie Chen   +6 more
wiley   +1 more source

Role of NADPH Oxidase 4 in Corneal Endothelial Cells Is Mediated by Endoplasmic Reticulum Stress and Autophagy. [PDF]

Antioxidants (Basel), 2023
Ma DJ, Hwang JS, Noh KB, Oh SH, Kim KW, Shin YJ.   +5 more
europepmc   +1 more source

Proteomic Analysis of Mixed Cell Membrane Extracts From Triple‐Negative Breast Cancer Cell Lines Revealed Broad Metabolic Reprogramming Associated With Tumor Progression

PROTEOMICS, EarlyView.
ABSTRACT Triple‐negative breast cancer (TNBC) represents the most aggressive subtype with limited therapeutic options and the poorest clinical outcomes. Using high‐resolution nUPLC‐QTOF‐MS/MS, we performed comprehensive proteomic profiling of TNBC cell lines representing disease progression stages: HCC‐1937 (stage IIB), HCC‐1599 (stage IIIA), and MDA ...
Claudia Sissely Chaviano‐Montes de Oca, Violeta Larios‐Serrato, María Luisa Labra‐Barrios, Emmanuel Ríos‐Castro, Carlos Alberto Castañón‐Sánchez, Rodolfo Moreno‐Castillo, Erika Beatriz Ángeles‐Morales, Juan Pedro Luna‐Arias   +7 more
wiley   +1 more source

Mechanisms of NADPH oxidase expression in cultured monocytes

, 2001
The abstract regards the mechanisms of expression of different NADPH oxidase components in cultured ...
DONINI, Marta, MAZZI, Paola, LISSANDRINI, Daniele, DUSI, Stefano   +3 more
core   +1 more source

NADPH oxidase 4 (NOX4) [PDF]

Science-Business eXchange, 2013
openaire   +1 more source