Results 51 to 60 of about 28,923 (304)

Shrimp Virus Regulates ROS Dynamics via the Nrf2 Pathway to Facilitate Viral Replication

Advanced Science, EarlyView.
Viruses manipulate host ROS as a strategy to achieve successful infection. WSSV exploits Nrf2 pathway to maintain ROS homeostasis and establishes a positive feedback loop to facilitate WSSV replication. Wsv220 competitively binds to Keap1 to activate Nrf2. Nrf2 up‐regulates LvG6PDH to produce more NADPH and GSH to eliminate excessive ROS.
Honghui He, Kai Yuan, Junming Pan, Shaoping Weng, Chaozheng Li, Yihong Chen, Jianguo He   +6 more
wiley   +1 more source

Redox Signaling of NADPH Oxidases Regulates Oxidative Stress Responses, Immunity and Aging

Antioxidants, 2018
An accumulating body of evidence suggests that transient or physiological reactive oxygen species (ROS) generated by nicotinamide adenine dinucleotide phosphate (NADPH) oxidases act as a redox signal to re-establish homeostasis.
Collin Y. Ewald
doaj   +1 more source

Distinction between 2′- and 3′-Phosphate Isomers of a Fluorescent NADPH Analogue Led to Strong Inhibition of Cancer Cells Migration

Antioxidants, 2021
Specific inhibition of NADPH oxidases (NOX) and NO-synthases (NOS), two enzymes associated with redox stress in tumor cells, has aroused great pharmacological interest.
Raoul Manuel, Michelle de Souza Lima, Sébastien Dilly, Sylvain Daunay, Patricia Abbe, Elodie Pramil, Stéphanie Solier, Fabienne Guillaumond, Sarah-Simha Tubiana, Alexandre Escargueil, João Antonio Pêgas Henriques, Nathalie Ferrand, Irène Erdelmeier, Jean-Luc Boucher, Gildas Bertho, Israel Agranat, Stéphane Rocchi, Michèle Sabbah, Anny Slama Schwok   +18 more
doaj   +1 more source

Multi-functional oxidase-like activity of praseodymia nanorods and nanoparticles [PDF]

Applied Surface Science 2023, 610, 155502
The ability to mimic protein-based oxidase with multi-functional inorganic nanozymes would greatly advance biomedical and clinical practices. Praseodymia (PrOx) nanorods (NRs) and nanoparticles (NPs) have been synthesized using hydrothermal and precipitation methods.
arxiv   +1 more source

NADPH Oxidase Deficiency: A Multisystem Approach [PDF]

Oxidative Medicine and Cellular Longevity, 2017
The immune system is a complex system able to recognize a wide variety of host agents, through different biological processes. For example, controlled changes in the redox state are able to start different pathways in immune cells and are involved in the killing of microbes.
Giuliana Giardino, Maria Pia Cicalese, Ottavia Delmonte, Maddalena Migliavacca, Boaz Palterer, Lorenzo Loffredo, Emilia Cirillo, Vera Gallo, Francesco Violi, Claudio Pignata   +9 more
openaire   +4 more sources

Single‐Cell Transcriptomes of Immune Cells from Multiple Compartments Redefine the Ontology of Myeloid Subtypes Post‐Stroke

Advanced Science, EarlyView.
Using single‐cell sequencing in a murine stroke model (p‐MCAO), three stroke‐specific subpopulations are identified: disease inflammatory macrophage (DIM), disease‐associated microglia (DAM), and CD14+ neutrophils (Neut_Cd14). Detailed analyses reveal that Neut_Cd14 and DIM subtypes are skull‐derived, whereas DAM likely originates from homeostatic ...
Mo Yang, Yixiang Li, Kaibin Shi, Xuezhu Wang, Xiangrong Liu, Xiang Huang, Fu‐Dong Shi, Shaojie Ma, Mingfeng Li, Yilong Wang   +9 more
wiley   +1 more source

NADPH Oxidases, Angiogenesis, and Peripheral Artery Disease

Antioxidants, 2017
Peripheral artery disease (PAD) is caused by narrowing of arteries in the limbs, normally occurring in the lower extremities, with severe cases resulting in amputation of the foot or leg.
Pradeep Manuneedhi Cholan, Siân P. Cartland, Mary M. Kavurma   +2 more
doaj   +1 more source

Reaction of the desulfoferrodoxin from Desulfoarculus baarsii with superoxide anion. Evidence for a superoxide reductase activity [PDF]

The journal of biological chemistry, American Society for Biochemistry and Molecular Biology, 2000, 275, pp.115-21, 2014
Desulfoferrodoxin is a small protein found in sulfate-reducing bacteria that contains two independent mononuclear iron centers, one ferric and one ferrous. Expression of desulfoferrodoxin from Desulfoarculus baarsii has been reported to functionally complement a superoxide dismutase deficient Escherichia coli strain.
arxiv   +1 more source

Clarity on the Isoform-Specific Roles of NADPH Oxidases and NADPH Oxidase-4 in Atherosclerosis [PDF]

Arteriosclerosis, Thrombosis, and Vascular Biology, 2016
Atherosclerosis is a complex disease that remains a leading cause of death and disability. The formation of vascular plaques arises from the interaction of dyslipidemia with the altered function of blood vessels and immune cells. The exact cause of atherosclerosis is not known, but from the 1950s onward, oxidative modifications of lipids and proteins ...
David Fulton, Scott A. Barman
openaire   +3 more sources

Recent Advancements in Lung Cancer Metastasis Prevention Based on Nanostrategies

Advanced Science, EarlyView.
Metastasis is the leading cause of death in patients with lung cancer. Nanomedicine can be used to prepare efficient drug delivery systems owing to their advantages and plays an important role in the synergistic antimetastasis of lung cancer. This comprehensive review summarizes the emerging nanostrategies against lung cancer metastasis based on the ...
Fan Xu, Yao Liu, Zujun Que, Bin Luo, Yun Yang, Yan Li, Zhanxia Zhang, Jianhui Tian   +7 more
wiley   +1 more source