Results 61 to 70 of about 30,089 (299)

Melatonin Modulates Glucose Metabolism Reprogramming via Targeting G6PD to Alleviate Lead‐Induced Hepatocytes Pyroptosis in Common Carp (Cyprinus carpio L.)

Advanced Science, EarlyView.
This study reveals that Lead reprograms glucose metabolism to enhance H3K18la, driving DRP1‐dependent mitochondrial DNA leakage and cGAS‐STING‐mediated pyroptosis. Melatonin targets G6PD to suppress glycolysis‐driven H3K18la and restore mitochondrial homeostasis, thereby alleviating Lead‐induced liver injury in common carp through disruption of the ...
Zhiying Miao, Xiaofeng Ji, Lai Wei, Zhiruo Miao, Shiwen Xu   +4 more
wiley   +1 more source

NOX/NADPH Oxidase, the Superoxide-Generating Enzyme: Its Transcriptional Regulation and Physiological Roles

Journal of Pharmacological Sciences, 2010
NADPH oxidase is a superoxide (O2−)-generating enzyme first identified in phagocytes that shows bactericidal activities. It has been reported that O2− is also produced in an NADPH-dependent manner in non-phagocytes. In the last decade, non-phagocyte-type
Masato Katsuyama
doaj   +1 more source

Nuclear factor-kappaB regulates the transcription of NADPH oxidase 1 in human alveolar epithelial cells

BMC Pulmonary Medicine, 2021
Objective Acute lung injury (ALI) is characterized by inflammation and oxidative stress. Nuclear factor-kappaB (NF-κB) mediates the expression of various inflammation-related genes, including the NADPH oxidase family.
Weijing Wu, Li Li, Xiaoshan Su, Zhixing Zhu, Xiaoping Lin, Jiamin Zhang, Zesen Zhuang, Hongyi Cai, Wenjie Huang   +8 more
doaj   +1 more source

Vascular Functions of NADPH Oxidases [PDF]

Hypertension, 2010
NADPH oxidases belong to a group of enzymes that generate reactive oxygen species (ROS) by electron transfer from NADPH to molecular oxygen. The product of this reaction is the superoxide anion (O2−), which undergoes secondary reactions. O2− inactivates NO to yield peroxynitrite and spontaneously or under catalysis of superoxide dismutases reacts to ...
openaire   +2 more sources

VAS2870 is a pan-NADPH oxidase inhibitor [PDF]

Cellular and Molecular Life Sciences, 2012
In their detailed review ‘‘NADPH oxidases as therapeutic targets in ischemic stroke’’ [1], Kahles and Brandes discuss the pathological roles of NADPH oxidases in ischemic brain injury and the therapeutic implications. In agreement with the authors, we consider inhibition of NADPH oxidases as a promising strategy to treat ischemic stroke.
Kirstin Wingler, Sebastian A. Altenhoefer, Pamela W. M. Kleikers, Kim A. Radermacher, Christoph Kleinschnitz, Harald H. H. W. Schmidt   +5 more
openaire   +4 more sources

Glycolytic Enzyme HK2 Phosphorylates nSMase1 to Promote Astrocytic Exosomes Biogenesis Contributing to Acute Ischemic Stroke Injury

Advanced Science, EarlyView.
This study reveals that the glycolytic enzyme HK2 mediates hypoxia‐induced astrocytic exosome biogenesis by directly phosphorylating nSMase1. These astrocytic exosomes impair brain endothelial tight junctions. Astrocyte‐specific knockdown of HK2 reduces exosome release and alleviates brain injury after MCAO.
Chen Chen, YuWei Zhou, LongXiang Sheng, FangYing Mai, YuXuan Ding, ShiRan Hong, JiaXin Wu, JiaKai Pi, GuangMei Yan, YiJun Huang, JingJing Duan, Xuefeng Hua, Wei Yin   +12 more
wiley   +1 more source

H2O2‐Activated Serotonin Precursor Probe for Mapping Neuronal Redox Homeostasis Reveals 5‐HT Interactions with Neighboring Proteins Under Oxidative Stress

Advanced Science, EarlyView.
HOP, an innovative ICT‐based fluorescent probe, visualizes H2O2 in stressed neurons while locally releasing serotonin (5‐HT) for real‐time protein interaction mapping. Its unique tandem sensing and labeling strategy reveals 5‐HT's role under oxidative stress, offering a powerful tool for neurophysiological research and therapeutic discovery.
Yani Liu, Jiwen Yuan, Tuanjie Zhang, Xinyi Cai, Meng Xu, Xueao Wang, Rui Wang, Bing Zhang, Hai‐Liang Zhu, Yong Qian   +9 more
wiley   +1 more source

Vascular NADPH Oxidases and Atherothrombotic Stroke

Stresses
Oxidative stress constitutes a main molecular mechanism underlying cardiovascular diseases (CVDs). This pathological mechanism can be triggered by NADPH oxidases (NOXs), which produce reactive oxygen species (ROS).
Javier Marqués, Guillermo Zalba
doaj   +1 more source

NADPH oxidase-mediated redox signaling promotes oxidative stress resistance and longevity through memo-1 in C. elegans

eLife, 2017
Transient increases in mitochondrially-derived reactive oxygen species (ROS) activate an adaptive stress response to promote longevity. Nicotinamide adenine dinucleotide phosphate (NADPH) oxidases produce ROS locally in response to various stimuli, and ...
Collin Yvès Ewald, John M Hourihan, Monet S Bland, Carolin Obieglo, Iskra Katic, Lorenza E Moronetti Mazzeo, Joy Alcedo, T Keith Blackwell, Nancy E Hynes   +8 more
doaj   +1 more source

Targeting Multilayered Metabolic Networks in Brain Diseases: Emerging Perspectives on Nanodelivery Strategies

Advanced Science, EarlyView.
Brain diseases involve multilayered metabolic disruptions that reshape cellular interactions and microenvironments. This review outlines core metabolic features across disease states and presents emerging nanodelivery strategies as precision tools to reprogram pathological metabolism.
Jingyi Zhou, Chen Jiang
wiley   +1 more source