Results 61 to 70 of about 296,542 (336)

The Regulation of Trace Metal Elements in Cancer Ferroptosis

Advanced Biology, EarlyView.
The induction of ferroptosis inhibits tumor growth, enhances anticancer efficacy, and overcomes drug resistance. Recent evidence shows nonferrous metal elements play a role in ferroptosis. This review focuses on how trace metals regulate ferroptosis processes like iron accumulation, lipid peroxidation, and antioxidant defense.
Xiaoyan Wang, Yuanyuan Xue, Lei Chang, Xuena Zhu, Wenjun Liu, Tingbo Liang   +5 more
wiley   +1 more source

NADPH oxidases and HIF1 promote cardiac dysfunction and pulmonary hypertension in response to glucocorticoid excess

Redox Biology, 2020
Cardiovascular side effects are frequent problems accompanying systemic glucocorticoid therapy, although the underlying mechanisms are not fully resolved.
Damir Kračun, Mathieu Klop, Anna Knirsch, Andreas Petry, Ivan Kanchev, Karel Chalupsky, Cordula M. Wolf, Agnes Görlach   +7 more
doaj  

Novel biosensors reveal a shift in the redox paradigm from oxidative to reductive stress in heart disease [PDF]

, 2016
No abstract ...
Anagnostopoulou, Aikaterini, De Lucca Camargo, Livia, Montezano, Augusto, Touyz, Rhian   +3 more
core   +1 more source

H2O2‐Generating Advanced Nanomaterials for Cancer Treatment

Advanced Functional Materials, EarlyView.
H2O2‐generating nanoplatforms can exploit tumor redox imbalance for O2 and toxic reactive oxygen species generation, leading to hypoxia reversal, and apoptosis of cancer cells, respectively. This review highlights the mechanisms of these nanoplatforms, including exogenous H₂O₂ delivery, endogenous amplification, and metal peroxides, which leads to ...
Kiyan Musaie, Samin Abbaszadeh, Kik Marais, Vahideh Nosrati‐Siahmazgi, Saman Rezaei, Bo Xiao, Kamal Dua, Hélder A. Santos, Mohammad‐Ali Shahbazi   +8 more
wiley   +1 more source

Expanding the set of rhodococcal Baeyer–Villiger monooxygenases by high-throughput cloning, expression and substrate screening [PDF]

, 2012
To expand the available set of Baeyer–Villiger monooxygenases (BVMOs), we have created expression constructs for producing 22 Type I BVMOs that are present in the genome of Rhodococcus jostii RHA1.
A Alfieri, A. Riebel, C Szolkowy, D Sheng, DE Torres Pazmiño, DE Torres Pazmiño, DE Torres Pazmiño, E Bloois van, F Hollmann, F Secundo, F Zambianchi, G Gonzalo de, G. de Gonzalo, H. M. Dudek, HM Dudek, I Letunic, JD Stewart, JD Thompson, K Tamura, L. Rychlewski, M Ahmad, M Bocola, M Miyamoto, M Renz, M Seto, M. W. Fraaije, MD Mihovilovic, MD Mihovilovic, MP McLeod, MW Fraaije, MW Fraaije, MW Fraaije, NM Kamerbeek, NM Kamerbeek, NM Kamerbeek, P. Stepniak, R Orru, S Saheki, S Wu   +38 more
core   +4 more sources

From Mechanoelectric Conversion to Tissue Regeneration: Translational Progress in Piezoelectric Materials

Advanced Materials, EarlyView.
This review highlights recent progress in piezoelectric materials for regenerative medicine, emphasizing their ability to convert mechanical stimuli into bioelectric signals that promote tissue repair. Key discussions cover the intrinsic piezoelectric properties of biological tissues, co‐stimulation cellular mechanisms for tissue regeneration, and ...
Xinyu Wang, Sílvio Terra Stefanello, Victor Shahin, Yun Qian   +3 more
wiley   +1 more source

Structures of human dual oxidase 1 complex in low-calcium and high-calcium states

Nature Communications, 2021
Dual oxidases (DUOXs), assembled from the catalytic DUOX and the auxiliary DUOXA subunits, produce hydrogen peroxide by transferring electrons from intracellular NADPH to extracellular oxygen in a calcium-activated manner. Here authors report the cryo-EM
Jing-Xiang Wu, Rui Liu, Kangcheng Song, Lei Chen   +3 more
doaj   +1 more source

Multi-functional oxidase-like activity of praseodymia nanorods and nanoparticles [PDF]

Applied Surface Science 2023, 610, 155502
The ability to mimic protein-based oxidase with multi-functional inorganic nanozymes would greatly advance biomedical and clinical practices. Praseodymia (PrOx) nanorods (NRs) and nanoparticles (NPs) have been synthesized using hydrothermal and precipitation methods.
arxiv   +1 more source

NOX Inhibitors - A Promising Avenue for Ischemic Stroke. [PDF]

, 2017
NADPH-oxidase (NOX) mediated superoxide originally found on leukocytes, but now recognized in several types of cells in the brain. It has been shown to play an important role in the progression of stroke and related cerebrovascular disease.
Kim, Jong Youl, Lee, Jong Eun, Park, Joohyun, Yenari, Midori A   +3 more
core   +1 more source

Supramolecular Gels as Active Tools for Reaction Engineering

Angewandte Chemie, EarlyView.
The unique combination of environments within gels, self‐assembled from low‐molecular‐weight gelators, offers the ability to control reactivity in new ways, achieving unique reaction outcomes, leading to the emerging concept of supramolecular gels as nanoreactors. Smart chemical engineering methods enable the use of such gels to fabricate materials and
David K. Smith
wiley   +2 more sources