Results 81 to 90 of about 30,089 (299)
NADPH oxidases in traumatic brain injury – Promising therapeutic targets?
Redox Biology, 2018 Traumatic brain injury (TBI) is a major cause of death and disability worldwide. Despite intense investigation, no neuroprotective agents for TBI have yet translated to the clinic.
Merry W. Ma +4 more
doaj +1 more source
Mechanisms of Activation of NADPH Oxidases
Japanese Journal of Infectious Diseases, 2004 The members of the NOX family of enzymes are expressed in a variety of tissues and serve a number of functions. There is a high level of conservation of primary protein sequence, as well as functional features, although specialized responses are beginning to emerge.
Robert A, Clark +2 more
openaire +2 more sources
Advanced Science, EarlyView.Se deficiency downregulates SELENOT, disrupting mitochondrial function and elevating mtROS to induce glucose metabolic reprogramming, NADPH depletion, cysteine accumulation, and disulfidptosis‐mediated actin cytoskeleton collapse in chicken skeletal muscle.
Huanyi Liu +5 more
wiley +1 more source
Advanced Science, EarlyView.This study engineers Yarrowia lipolytica to produce succinic acid (SA) from lignocellulosic biomass. Adaptive evolution and multi‐omics analysis identify regulators that alleviate xylose metabolic disorder. Multi‐copy integration of xylose metabolic genes resolves redox imbalances from a futile fatty acid cycle, producing high‐titer SA from corn stover
Yutao Zhong +7 more
wiley +1 more source
Advanced Science, EarlyView.The most elaborate known example of β‐oxidation‐like pathway recruitment in fungi is reported, involving a 10‐step oxidative chain‐shortening cascade catalyzed by five dedicated enzymes to generate the pharmacophore of mycophenolic acid (MPA)—a novel clinical immunosuppressant. Our findings illustrate how nature repurposes catabolic enzymes for complex
Baoqiang Fan +5 more
wiley +1 more source
Natural Compounds as Modulators of NADPH Oxidases [PDF]
Oxidative Medicine and Cellular Longevity, 2013 Reactive oxygen species (ROS) are cellular signals generated ubiquitously by all mammalian cells, but their relative unbalance triggers also diseases through intracellular damage to DNA, RNA, proteins, and lipids. NADPH oxidases (NOX) are the only known enzyme family with the sole function to produce ROS.
openaire +2 more sources
Advanced Science, EarlyView.Appressoria are specialized penetration structures for many plant pathogenic fungi, demanding precise cell cycle control. This study unveils MoMtg1 as a transcriptional repressor of MoSwi6, orchestrating MoCYC1 expression during turgor‐driven cell cycle progression to enable appressorium‐mediated penetration. Moreover, a small‐molecule inhibitor ZS1619
Xingyu Wang +11 more
wiley +1 more source
Advanced Science, EarlyView.A natural variation in soybean PM30, GmPM30‐HapT, confers greater salt tolerance than GmPM30‐HapC via stronger GmLEA1‐GmPM30‐GmLEC1 interactions. Pyramiding their elite haplotypes yields additive gains in salt tolerance and yield, establishing a novel workflow linking evolutionary genomics, molecular mechanisms, and breeding applications via the module
Shiyu Huang +13 more
wiley +1 more source
The superoxide-generating NADPH oxidase of human neutrophils is electrogenic and associated with an H+ channel [PDF]
, 1987 L. M. Henderson +2 more
openalex +1 more source
Integrating Metabolic Modulation and Nanomedicine for Cancer Immunotherapy
Advanced Science, EarlyView.Metabolic rewiring in cancer is mapped across glucose, amino acid, lipid, nucleotide, and mitochondrial pathways, with emphasis on immune regulation. The review integrates mechanisms linking these pathways to tumor progression and therapy resistance, and profiles nanomaterial platforms that both deliver therapeutics and actively reprogram ...
Xiaosu Zhou +7 more
wiley +1 more source