Results 81 to 90 of about 28,923 (304)

Role of NADPH Oxidase in the Endothelial Dysfunction and Oxidative Stress in Aorta of Aged Spontaneous Hypertensive Rats [PDF]

Iranian Journal of Basic Medical Sciences, 2010
Objective(s)Increased reactive oxygen species (ROS) production is implicated in the pathogenesis of arterial hypertension and the development of endothelial dysfunction.
Ashraf Taye, Sven Wind
doaj  

Reaction of the NAD(P)H:flavin oxidoreductase from Escherichia coli with NADPH and riboflavin: identification of intermediates [PDF]

Biochemistry, American Chemical Society, 1998, 37, pp.11879-87, 2014
Flavin reductase catalyzes the reduction of free flavins by NAD(P)H. As isolated, Escherichia coli flavin reductase does not contain any flavin prosthetic group but accommodates both the reduced pyridine nucleotide and the flavin substrate in a ternary complex prior to oxidoreduction.
arxiv  

Biomimetic Nanoplatform for Targeted Rheumatoid Arthritis Therapy: Modulating Macrophage Niches Through Self‐Sustaining Positive Feedback‐Driven Drug Release Mechanisms

Advanced Science, EarlyView.
Rheumatoid arthritis is an incurable inflammatory autoimmune disease. The cleverly biomimetic nanoplatform integrates nanoenzymes and gene therapeutics and is sequentially modified by guanidinium‐based polymers and macrophage membranes, enhancing the gene silencing capability and reactive oxygen species scavenging efficiency through self‐sustaining ...
Huichao Xie, Xiaoyu Huang, Bao Li, Yongfeng Chen, Haoran Niu, Tong Yu, Shimei Yang, Shuxin Gao, Yutong Zeng, Tianzhi Yang, Yan Kang, Keda Zhang, Pingtian Ding   +12 more
wiley   +1 more source

Exogenous niacin treatment increases NADPH oxidase in kiwifruit

Brazilian Journal of Biology, 2018
Kiwifruit are a popular fruit worldwide; however, plant growth is threatened by abiotic stresses such as drought and high temperatures. Niacin treatment in plants has been shown to increase NADPH levels, thus enhancing abiotic stresses tolerance.
X. Zhu, L. Pan, T. Xiao, X. Ren, Z. Liu
doaj   +1 more source

VAS2870 is a pan-NADPH oxidase inhibitor [PDF]

Cellular and Molecular Life Sciences, 2012
In their detailed review ‘‘NADPH oxidases as therapeutic targets in ischemic stroke’’ [1], Kahles and Brandes discuss the pathological roles of NADPH oxidases in ischemic brain injury and the therapeutic implications. In agreement with the authors, we consider inhibition of NADPH oxidases as a promising strategy to treat ischemic stroke.
Kirstin Wingler, Sebastian A. Altenhoefer, Pamela W. M. Kleikers, Kim A. Radermacher, Christoph Kleinschnitz, Harald H. H. W. Schmidt   +5 more
openaire   +4 more sources

Functional Materials Targeted Regulation of Gasdermins: From Fundamentals to Functionalities and Applications

Advanced Science, EarlyView.
Targeted regulation of pyroptosis to modulate the immune landscape is a novel design strategy for cancer immunotherapy and anti‐inflammatory treatment. Pyroptosis, as a double‐edged sword, underscores the importance of optimizing the design strategy of functional materials and appropriately activating pyroptosis for the effective treatment of diseases.
Luyao Tian, Shuo Piao, Xia Li, Lanping Guo, Luqi Huang, Wenyuan Gao   +5 more
wiley   +1 more source

NADPH oxidase-mediated redox signaling promotes oxidative stress resistance and longevity through memo-1 in C. elegans

eLife, 2017
Transient increases in mitochondrially-derived reactive oxygen species (ROS) activate an adaptive stress response to promote longevity. Nicotinamide adenine dinucleotide phosphate (NADPH) oxidases produce ROS locally in response to various stimuli, and ...
Collin Yvès Ewald, John M Hourihan, Monet S Bland, Carolin Obieglo, Iskra Katic, Lorenza E Moronetti Mazzeo, Joy Alcedo, T Keith Blackwell, Nancy E Hynes   +8 more
doaj   +1 more source

Vascular Functions of NADPH Oxidases [PDF]

Hypertension, 2010
NADPH oxidases belong to a group of enzymes that generate reactive oxygen species (ROS) by electron transfer from NADPH to molecular oxygen. The product of this reaction is the superoxide anion (O2−), which undergoes secondary reactions. O2− inactivates NO to yield peroxynitrite and spontaneously or under catalysis of superoxide dismutases reacts to ...
openaire   +2 more sources

Purine Metabolism and Dystonia: Perspectives of a Long‐Promised Relationship

Annals of Neurology, EarlyView.
Purine pool imbalance in purine metabolism disorders, such as Lesch–Nyhan disease, intersects with dystonia pathogenesis. The recent discovery of gain‐of‐function IMPDH2 pathogenic variants in patients with prominent dystonic manifestations provides new insights into the link between dystonia and purinergic system defects.
Ugo Sorrentino, Audrey G. O'Neill, Justin M. Kollman, Hyder A. Jinnah, Michael Zech   +4 more
wiley   +1 more source

Vascular NADPH Oxidases and Atherothrombotic Stroke

Stresses
Oxidative stress constitutes a main molecular mechanism underlying cardiovascular diseases (CVDs). This pathological mechanism can be triggered by NADPH oxidases (NOXs), which produce reactive oxygen species (ROS).
Javier Marqués, Guillermo Zalba
doaj   +1 more source