Results 101 to 110 of about 129,447 (312)

Gene-Targeted Next Generation Sequencing Identifies PNPLA1 Mutations in Patients with a Phenotypic Spectrum of Autosomal Recessive Congenital Ichthyosis: The Impact of Consanguinity [PDF]

open access: yes, 2017
Heritable forms of ichthyoses, also referred to as generalized Mendelian disorders of cornification, are phenotypically a highly heterogeneous group of conditions caused by mutations in a number of genes playing a role in keratinocyte differentiation ...
Abiri, Maryam   +12 more
core   +1 more source

One size does not fit all: An in vitro evaluation of the effects of bezafibrate and medroxyprogesterone acetate on human SH‐SY5Y and U‐87 MG cancer cells

open access: yesFEBS Open Bio, EarlyView.
Drugs previously repurposed to target blood cancers reduced neuroblastoma and glioblastoma cell growth and viability. However, their levels of anticancer activity were different and their clinical application may be problematic due to side effects at effective doses.
Abhishek Kharawatkar   +4 more
wiley   +1 more source

Identification of nail diseases using DenseNet169 with leaky ReLU and LSTM with data balancing method

open access: yesDiscover Computing
Nail diseases pose significant health concerns and often require prompt diagnosis and treatment. The authors propose a new approach for identifying nail diseases using advanced deep learning (DL) techniques. Specifically, we employ a modified DenseNet169
Kamini G. Panchbhai   +3 more
doaj   +1 more source

Whitlow, felon and paronychia - a clinical review of superficial hand infections

open access: yesQuality in Sport
Paronychia, felon and herpetic whitlow are common superficial hand infections. Although having similarities there are many differences between clinical presentation and treatment. Paronychia can present as acute and chronic condition.
Mikołaj Domański   +7 more
doaj   +1 more source

Monoreactive high affinity and polyreactive low affinity rheumatoid factors are produced by CD5+ B cells from patients with rheumatoid arthritis. [PDF]

open access: yes, 1988
In patients with rheumatoid arthritis (RA), circulating CD5+ B lymphocytes, but not CD5- B lymphocytes, are increased in number and size, exist in an activated state, spontaneously proliferate, and secrete Ig that binds to the Fc fragment of IgG.
Burastero, SE   +3 more
core   +1 more source

Natural Products as Geroprotective Modulators in Diabetic Nephropathy: A Mechanistic Framework Integrating Aging Hallmarks and the AMPK–SIRT1–Nrf2 Axis

open access: yesAging and Cancer, EarlyView.
Natural products target the aging kidney in diabetic nephropathy by restoring the AMPK–SIRT1–Nrf2 axis, reducing oxidative stress, inflammation, fibrosis, and cellular senescence while enhancing mitochondrial biogenesis and antioxidant defenses.
Sherif Hamidu   +8 more
wiley   +1 more source

Tofacitinib successful treatment of idiopathic twenty-nail dystrophy: a case report

open access: yesJournal of Dermatological Treatment
Purpose Twenty-nail dystrophy (TND) is a chronic nail disorder affecting all or some nails and posing a significant therapeutic challenge for dermatologists.
Wenjun Zhao, Shijun Shan, Dongmei Liu
doaj   +1 more source

Tomatoes for Canning [PDF]

open access: yes, 1931
PDF pages ...
Lancashire, E. R.
core  

Human Inborn Errors of Immunity: 2019 Update of the IUIS Phenotypical Classification. [PDF]

open access: yes, 2020
Since 2013, the International Union of Immunological Societies (IUIS) expert committee (EC) on Inborn Errors of Immunity (IEI) has published an updated phenotypic classification of IEI, which accompanies and complements their genotypic classification ...
Ailal, Fatima   +18 more
core  

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