Results 61 to 70 of about 2,208,935 (290)
The microbiome in human skin aging
FEBS Letters, EarlyView.Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana +3 more
wiley +1 more source
, 2005 The changes in brittle, friable nails are often confined to the surface of the nail plate; this occurs in superficial white onychomycosis and may be seen after the application of nail polish or base coat which causes ‘granulations’ in the nail keratin ...
core +2 more sources
Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding
FEBS Letters, EarlyView.In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança +2 more
wiley +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
When all you have is a dermatoscope—start looking at the nails
Dermatology Practical & Conceptual, 2014 Pigmented and non-pigmented nail alterations are a frequent challenge for dermatologists. A profound knowledge of clinical and dermatoscopic features of nail disorders is crucial because a range of differential diagnoses and even potentially life ...
Holger A. Haenssle +7 more
doaj +1 more source
Differential Diagnosis for Nail Psoriasis
, 2014 Nail involvement occurs in up to 50 % of patients with psoriasis. Although most patients experience concurrent skin involvement, 1–5 % of patients present with nail changes alone. In these patients, it can be diagnostically challenging, as psoriatic nail
Antonella Tosti +3 more
core +1 more source
Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source
A finite element strategy applied to intramedullary nailing of the proximal femur [PDF]
, 2005 This thesis was submitted for the degree of Doctor of Philosophy and was awarded by Brunel University.An intramedullary nail is a trauma treatment device used for fracture fixation of long bones. These devices are subject to failure, including lag screw
Simpson, David John
core +5 more sources
Is there a bone-nail specific entry point? automated fit quantification of tibial nail designs during the insertion for six different nail entry points [PDF]
, 2015 Intramedullary nailing is the standard fixation method for displaced diaphyseal fractures of tibia. Selection of the correct nail insertion point is important for axial alignment of bone fragments and to avoid iatrogenic fractures.
Schuetz, Michael +7 more
core +1 more source
MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source