Results 71 to 80 of about 129,447 (312)

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

When all you have is a dermatoscope—start looking at the nails

Dermatology Practical & Conceptual, 2014
Pigmented and non-pigmented nail alterations are a frequent challenge for dermatologists. A profound knowledge of clinical and dermatoscopic features of nail disorders is crucial because a range of differential diagnoses and even potentially life ...
Holger A. Haenssle, Andreas Blum, Rainer Hofmann-Wellenhof, Juergen Kreusch, Wilhelm Stolz, Giuseppe Argenziano, Iris Zalaudek, Franziska Brehmer   +7 more
doaj   +1 more source

Minimization of Illness Absenteeism in Primary School Students Using Low-Cost Hygiene Interventions [PDF]

, 2012
Objective: Safe water and hygiene intervention was evaluated to assess its impact on students’ health, hygiene practices and reduction in illness absenteeism in primary school students.
Shirsat, SD, Tambekar, DH
core  

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Comparison of oral prednisolone pulse therapy with intravenous methylprednisolone pulse therapy in severe alopecia areata [PDF]

, 2013
Objective: To compare the efficacy of oral prednisolone pulse therapy in comparison to the intravenous methylprednisolone pulse therapy in treatment of severe alopecia areata. Patients and methods: In this interventional study, all patients with alopecia
Alborzi, A., Dehghan, A., Shahini, N.
core  

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source

A compendium of intralesional therapies in nail disorders

Indian Dermatology Online Journal, 2018
Nail unit is a complex skin appendage offering natural barrier to drug penetration by virtue of its unique anatomy. This is the reason why topical as well as oral therapies can be largely ineffective when dealing with nail diseases.
Chander Grover, Shikha Bansal
doaj   +1 more source

Nail-patella syndrome (Fong disease) [PDF]

Pediatric Radiology, 2010
A14-year-oldboypresentedtotheorthopedicclinicfornon-painful elbow deformities. Knee radiographs demonstratedsmall patellae (Fig. 1). Elbow radiographs showed disloca-tion of the right radial head (Fig. 2). Pelvic radiograph wasnormal. Physical exam revealed bilateral absence of nailson the thumb and index fingers.
Scott A, Mooney, Johnny U V, Monu
openaire   +2 more sources

Nail lacquer films’ surface energies and in vitro water-resistance and adhesion do not predict their in vivo residence [PDF]

, 2017
The in vivo residence of nail lacquers (which are ideal topical drug carriers for the treatment of nail diseases) determines their frequency of application, and is thereby expected to influence patient adherence and success of treatment.
Baran R, Hay R, Haneke E, Tosti A,, Braunagel, A.,, Kerai, L.V., Hilton, S., Murdan, S.,, Lacombe, R.,, Maibach, H. (Eds.),, Mididoddi, P.K., Repka, M.A.,, Murdan, S.,, Murdan, S.,, Murdan, S., Kerai, L., Hossin, B.,, Murdan, S., Poojary, C., Patel, D.R., Fernandes, J., Haman, A., Saundh, P.S., Sheikh, Z.,, PharmaPoint, G.,, Reich, K.,, Saner, M.V., Kulkarni, A.D., Pardeshi, C.V.,, Schlossman, M.L.,, Shivakumar, H.N., Repka, M.A., S, M., Murthy, S.N.,, Shivakumar, H.N., Vaka, S.R.K., Madhav, N.V.S., Chandra, H., Murthy, S.N.,, Tofallis, C.,, Van Oss, C.J.,, van Oss, C.J., Chaudhury, M.K., Good, R.J.,, van Oss, C.J., Chaudhury, M.K., Good, R.J.,, van Oss, C.J., Good, R.J., Chaudhury, M.K.,, Venkatraman, S., Gale, R.,   +21 more
core   +2 more sources

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source