Results 11 to 20 of about 1,414 (150)

Structure and function of the nairovirus cap-snatching endonuclease [PDF]

Nucleic Acids Research
Abstract Nairoviruses include several human pathogens such as Crimean-Congo hemorrhagic fever virus (CCHFV) and Kasokero virus (KASV). The cap-snatching endonuclease (EN) domain of the viral polymerase is essential for transcription and represents a promising antiviral target.
Zengqin Deng, Zhang Huanyu, Wang Manli   +2 more
exaly   +4 more sources

A novel nairovirus associated with acute febrile illness in Hokkaido, Japan [PDF]

Nature Communications, 2021
Here, Kodama et al. describe the discovery, isolation and characterization of a novel tick-borne orthonairovirus, designated Yezo virus (YEZV), from patients with an acute febrile illness in Japan.
Fumihiro Kodama, Hiroki Yamaguchi, Eunsil Park, Kango Tatemoto, Mariko Sashika, Ryo Nakao, Yurino Terauchi, Keita Mizuma, Yasuko Orba, Hiroaki Kariwa, Katsuro Hagiwara, Katsunori Okazaki, Akiko Goto, Rika Komagome, Masahiro Miyoshi, Takuya Ito, Kimiaki Yamano, Kentaro Yoshii, Chiaki Funaki, Mariko Ishizuka, Asako Shigeno, Yukari Itakura, Lesley Bell-Sakyi, Shunji Edagawa, Atsushi Nagasaka, Yoshihiro Sakoda, Hirofumi Sawa, Ken Maeda, Masayuki Saijo, Keita Matsuno   +29 more
doaj   +4 more sources

Inhibition of Hazara nairovirus replication by small interfering RNAs and their combination with ribavirin [PDF]

Virology Journal, 2011
Background The genus Nairovirus in the family Bunyaviridae contains 34 tick-borne viruses classified into seven serogroups. Hazara virus (HAZV) belongs to the Crimean-Congo hemorrhagic fever (CCHF) serogroup that also includes CCHF virus (CCHFV) a major ...
Crance Jean-Marc, Bouloy Michèle, Peyrefitte Christophe N, Vigne Solenne, Flusin Olivier, Iseni Frédéric   +5 more
doaj   +4 more sources

Kupe Virus, a New Virus in the Family Bunyaviridae, Genus Nairovirus, Kenya

Emerging Infectious Diseases, 2009
We have previously described isolation and preliminary identification of a virus related to Dugbe virus (DUGV), family Bunyaviridae, genus Nairovirus.
Mary Crabtree, Rosemary Sang, Barry R. Miller   +2 more
doaj   +3 more sources

Cranberry (Vaccinium macrocarpon) Extract Impairs Nairovirus Infection by Inhibiting the Attachment to Target Cells [PDF]

Pathogens, 2021
Hazara virus (HAZV) belongs to the Nairoviridae family and is included in the same serogroup of the Crimean-Congo hemorrhagic fever virus (CCHFV). CCHFV is the most widespread tick-borne arbovirus. It is responsible for a serious hemorrhagic disease, for
Mattia Mirandola, Maria Vittoria Salvati, Carola Rodigari, K. Sofia Appelberg, Ali Mirazimi, Massimo E. Maffei, Giorgio Gribaudo, Cristiano Salata   +7 more
doaj   +4 more sources

Inhibition of interferon induction and action by the nairovirus Nairobi sheep disease virus/Ganjam virus.

PLoS ONE, 2011
The Nairoviruses are an important group of tick-borne viruses that includes pathogens of man (Crimean Congo hemorrhagic fever virus) and livestock animals (Dugbe virus, Nairobi sheep disease virus (NSDV)).
Barbara Holzer, Siddharth Bakshi, Anne Bridgen, Michael D Baron   +3 more
doaj   +3 more sources

Metatranscriptomic Analysis Uncovers RNA Virus Diversity in Ticks From the China-Russia-North Korea Border Region. [PDF]

Transbound Emerg Dis
Ticks serve as critical viral vectors, and border regions, acting as convergence zones of complex ecosystems, provide diverse habitats for ticks and their hosts, thereby underscoring the need to investigate the tick‐borne virome composition in such areas. In this study, metatranscriptomic analysis of five tick species, namely Haemaphysalis longicornis,
Liu Z, Ji S, Wang J, Li Y, Galon EM, Wang S, Li J, Gao X, Yu L, Wang Y, Song J, Cui Q, Li C, Xu Z, Xue S.   +14 more
europepmc   +2 more sources

Structural and functional characterisation of the Crimean-Congo haemorrhagic fever virus RNA dependent RNA polymerase

Nature Communications
Crimean-Congo Haemorrhagic Fever Virus (CCHFV) is found across Africa, Asia, and the Middle East where it can cause Haemorrhagic outbreaks with high case fatality rates.
Adrian Deng, Rory Cunnison, Loïc Carrique, Franziska Günl, Els Pardon, Jan Steyaert, David Nguyen Duc, Jonathan M. Grimes, Nicole Robb, Jeremy R. Keown   +9 more
doaj   +2 more sources

Exploring the Potential of Iminosugars as Antivirals for Crimean-Congo Haemorrhagic Fever Virus, Using the Surrogate Hazara Virus: Liquid-Chromatography-Based Mapping of Viral N-Glycosylation and In Vitro Antiviral Assays

Pathogens, 2023
Crimean-Congo haemorrhagic fever virus (CCHFV) is a pathogen of increasing public health concern, being a widely distributed arbovirus and the causative agent of the potentially fatal Crimean-Congo haemorrhagic fever. Hazara virus (HAZV) is a genetically
Beatrice E. Tyrrell, Abhinav Kumar, Bevin Gangadharan, Dominic Alonzi, Juliane Brun, Michelle Hill, Tehmina Bharucha, Andrew Bosworth, Victoria Graham, Stuart Dowall, Joanna L. Miller, Nicole Zitzmann   +11 more
doaj   +1 more source

Identification and Phylodynamic Analysis of the Siberian Subtype of Tick-Borne Encephalitis Virus in Tick-Bitten Patients From Northeastern China. [PDF]

Transbound Emerg Dis
Far Eastern (FE) tick‐borne encephalitis virus (TBEV) was thought to be the only endemic subtype in northeastern China. However, in 2024, the Siberian (Sib) subtype of TBEV was found in ticks. This study investigates Sib‐TBEV infection in tick‐bitten patients in the region.
Wei Z, Liu Z, Liu Y, Liu N, Ren Y, Han S, Zheng X, Lv X, Wang Z.   +8 more
europepmc   +2 more sources