Results 91 to 100 of about 835,919 (230)

Long-lived cancer-resistant rodents as new model species for cancer research

Frontiers in Genetics, 2013
Most rodents are small and short-lived, but several lineages have independently evolved long lifespans without a concomitant increase in body mass.
Jorge eAzpurua, Andrei eSeluanov
doaj   +1 more source

The somatosensory world of the African naked mole-rat

, 2021
The naked mole-rat (Heterocephalus glaber) is famous for its longevity and unusual physiology. This eusocial species that lives in highly ordered and hierarchical colonies with a single breeding queen, also discovered secrets enabling somewhat pain-free ...
Debus, K., Jane Reznick, Lewin, G., Gary R. Lewin, Karlien Debus, Lewin, G.R., Alison J. Barker, Reznick, J., Park , T., Ewan St. J. Smith, Barker, A., Smith, E.S.J., Debus, K.Y., Thomas J. Park, Barker, A.J., Park, T.J., Smith, E.   +16 more
core   +1 more source

Oral Recombinant Human Collagen III Protects Gastric Mucosa via G‐Quadruplex‐Mediated Activation of the Pla2g4a‐Prostaglandin Axis

Advanced Science, EarlyView.
Orally administered recombinant human type III collagen protects the gastric mucosa from ethanol‐induced injury by coordinating redox homeostasis, epithelial barrier repair, and arachidonic acid–prostaglandin metabolism. Gastric digestion releases the pentapeptide GPAEF, which interacts with the Pla2g4a promoter G‐quadruplex in a structure‐dependent ...
Xinyue Lan, Qiu Dai, Yanhui Wang, Jiaxuan Gu, Chengyun Wang, Weicheng Xu, Xinru Gao, Jiageng Cheng, Wentao Geng, Xiaowen Wu, Haihang Li, Xiaoyun He, Shengwei Fu, Longjiao Zhu, Wentao Xu   +14 more
wiley   +1 more source

AARS2‐SIRT5‐Driven DLD K445 Lactylation Promotes Cuproptosis Resistance in Glioblastoma Stem Cells

Advanced Science, EarlyView.
Lactylation of DLD at K445 by AARS2 suppresses PDH complex activity and reduces DLAT lipoylation, thereby conferring cuproptosis resistance in glioblastoma stem cells. SIRT5‐mediated delactylation restores PDH function and enhances cuproptosis sensitivity.
Mingtian Ding, Haibiao Xu, Cen Liu, Yangyin Ding, Shuai Wang, Jun Yin, Tao Fu, Xiao Jiang, Yuning Chen, Hui Luo, Rui Li, Zhengxin Chen, Huibo Wang   +12 more
wiley   +1 more source

An Improve Naked Mole Rat Trap, Group III [PDF]

, 2016
This project attempts to improve on Dr. Stan Braude’s current Naked Mole Rat trap design. Dr. Braude currently uses his trap to catch and tag naked mole rats for his research. While Dr. Braude is happy with his current trap, he designed them himself over
Daley, Ted, Egly, Spencer, Thompson, Andrew   +2 more
core  

Excitation‐Selective Hydrochromic Upconversion in Zero‐Dimensional Metal Halides

Advanced Science, EarlyView.
Excitation wavelength dictates whether moisture speaks. In zero‐dimensional metal halides, the same humidity leaves the upconversion emission unchanged under 980 nm excitation yet triggers a distinct green‐to‐red shift under 1550 nm. This excitation‐selective hydrochromism, governed by the absorption at each wavelength, enables stimulus‐dependent ...
Joo Hyeong Han, Jeong Min Seo, Sung Woo Jang, Yong Min Park, San Ha Choi, Ji Hyeon Cha, Won Bin Im   +6 more
wiley   +1 more source

Cutaneous and periodontal inputs to the cerebellum of the naked mole-rat (Heterocephalus glaber)

Frontiers in Neuroanatomy, 2013
The naked mole-rat (Heterocephalus glaber) is a small fossorial rodent with specialized dentition that is reflected by the large cortical area dedicated to representation of the prominent incisors.
Diana K Sarko, Duncan B Leitch, Kenneth C Catania   +2 more
doaj   +1 more source

3D Bioprinted Blood–Brain–Tumor Barrier Spheroid‐Based In Situ Evaluation of Anticancer Compounds Against Glioblastoma: ROS‐Producing Ruthenium as a Potential Therapeutic Candidate

Advanced Science, EarlyView.
The blood–brain–tumor barrier (BBTB) penetration by anticancer drugs and their effects on glioblastoma (GBM) is assessed using 3D bioprinted‐spheroids. Anticancer drug‐induced U‐87 MG cell death is quantified through in situ imaging of spheroids using a cancer cell death probe. The Ru compound, a partial P‐gp substrate, induces greater tumor‐cell death
Hyunjung Lee, Chan Ho Jeon, Doyun Kim, Minjae Lee, Minji Kwon, Joon Myong Song   +5 more
wiley   +1 more source

crisscrossing Science Episode 008: Naked Mole-rats [PDF]

, 2016
In this episode, Chris Gaiser (professor of biology at Linfield College) and Mike Crosser (professor of physics at Linfield College) discuss the fascinating qualities of the naked mole-rat, including its eusociality, long lifespan, and resistance to ...
Crosser, Michael S., Gaiser, J. Christopher   +1 more
core   +1 more source

Porphyrin‐Based Porous Materials for Antibacterial Applications

Advanced Science, EarlyView.
Porphyrin‐based porous materials have excellent photophysical properties and tunable structures for high‐efficiency antibacterial therapy. This review comprehensively discusses the structural design strategies and synthetic pathways of the four main types of porphyrin‐based porous materials, summarizes their cross‐domain antimicrobial applications, and
Xiao‐Xue Liang, Xin Li, Ying Xiong, Xin Wang, Ying‐Wei Yang   +4 more
wiley   +1 more source