Results 81 to 90 of about 835,919 (230)

Naked Mole Rat Induced Pluripotent Stem Cells and Their Contribution to Interspecific Chimera

Stem Cell Reports, 2017
Summary: Naked mole rats (NMRs) are exceptionally long-lived, cancer-resistant rodents. Identifying the defining characteristics of these traits may shed light on aging and cancer mechanisms.
Sang-Goo Lee, Aleksei E. Mikhalchenko, Sun Hee Yim, Alexei V. Lobanov, Jin-Kyu Park, Kwang-Hwan Choi, Roderick T. Bronson, Chang-Kyu Lee, Thomas J. Park, Vadim N. Gladyshev   +9 more
doaj   +1 more source

Engineered Allosteric Biosensor for In Situ DNA Glycosylase Detection in Neuroblastoma Risk Stratification and Drug Resistance Monitoring

Advanced Science, EarlyView.
An engineered allosteric biosensor (UUU‐DZ‐tFNA) was developed, in which UDG specifically recognizes and activates a DNAzyme to achieve signal cycle amplification in a sequentially activatable mode. UUU‐DZ‐tFNA achieves in situ UDG detection across multiple biological levels and facilitates risk stratification and drug resistance monitoring of NB ...
Yaqing Lu, Yingyu Zhang, Xianwei Zhang, Mengxin Zhang, Fei Zhang, Jushan Sun, Yahui Yang, Kangbo Liu, Peng Wang, Shuying Luo, Wancun Zhang   +10 more
wiley   +1 more source

Extreme Resistance to Oxygen Deprivation in Brain Tissue from the Naked Mole-Rat

, 2012
The naked mole-rat lives in large colonies living completely underground, a very unique way of life. This leads to an environment where the air is low in oxygen and high in carbon dioxide.
Bethany L. Peterson (7936517)
core   +2 more sources

Accelerated Evolution in Distinctive Species Reveals Candidate Elements for Clinically Relevant Traits, Including Mutation and Cancer Resistance

Cell Reports, 2018
Summary: The identity of most functional elements in the mammalian genome and the phenotypes they impact are unclear. Here, we perform a genome-wide comparative analysis of patterns of accelerated evolution in species with highly distinctive traits to ...
Elliott Ferris, Lisa M. Abegglen, Joshua D. Schiffman, Christopher Gregg   +3 more
doaj   +1 more source

The naked mole rat genome resource: facilitating analyses of cancer and longevity-related adaptations. Bioinformatics 30:3558–3560

, 2014
Motivation: The naked mole rat (Heterocephalus glaber) is an exceptionally long-lived and cancer-resistant rodent native to East Africa. Although its genome was previously sequenced, here we report a new assembly sequenced by us with substantially higher
Vera Gorbunova, George M Church, João Pedro De Magalhães, Andrei Seluanov, Jeremy Johnson, Federica Di Palma, Kerstin Lindblad-Toh, Michael Keane, Thomas Craig, Aaron M Berlin, Alf € Oldi, Jessica, John Hancock   +12 more
core  

Hormonal aspects of reproductive suppression in the naked mole-rat, Heterocephalus glaber [PDF]

, 2006
Includes bibliographical references.Subordinate, female naked mole-rats (Heterocephalus g/aber) are anovulatory as a result of extremely low luteinising hormone (LH) levels.
Tuomi, Erin Bianca
core   +1 more source

Restores Aβ Clearance by Overcoming PCSK9–LRP1 Dysregulation and TRIB3‐Mediated Autophagy Blockade in Alzheimer's Disease

Advanced Science, EarlyView.
PCSK9 upregulation in cerebrovascular endothelial cells and microglia destabilizes the Aβ transporter LRP1, while TRIB3‐associated autophagy blockade further limits intracellular Aβ degradation. A RAP‐modified tea‐polyphenol nanoparticle co‐delivers siPCSK9 and siTRIB3 to restore LRP1‐mediated Aβ efflux and autophagy‐dependent degradation, reducing Aβ ...
Jie Miao, Jing Wang, Yankun Li, Haipei Zhang, Yanli Zhang, Qingnian Li, Bo Xiao, Wenhu Zhou, Junhong Guo   +8 more
wiley   +1 more source

Degrading GPX4 via Biomimetic Nanoparticle‐Mediated In Situ Synthesis of Deep‐Learning‐Designed Binder‐Degron Chimeras for Prostate Cancer Therapy

Advanced Science, EarlyView.
A deep‐learning‐designed binder is fused to a combinatorial degron to create a binder‐degron chimera (bdC) that recruits the CUL2‐RING ubiquitin ligase complex. Encapsulation in a prostate‐cancer‐targeted, CD47‐camouflaged nanocarrier enables tumor‐specific in situ bdC expression, triggering GPX4 degradation and ferroptosis, thereby establishing a ...
Si‐Han Zhang, Ye An, Na Zeng, Mei‐Cheng Liu, Jian‐Xuan Sun, Xi Gong, Jin‐Zhou Xu, Shao‐Gang Wang, Qi‐Dong Xia   +8 more
wiley   +1 more source

Molecular and Physiological Factors of Neuroprotection in Hypoxia-tolerant Models: Pharmacological Clues for the Treatment of Stroke

Journal of Experimental Neuroscience, 2015
The naked mole-rat possesses several unique physiological and molecular features that underlie their remarkably and exceptional resistance to tissue hypoxia.
Thomas I. Nathaniel, Julius O. Soyinka, Adekunle Adedeji, Adebobola Imeh-Nathaniel   +3 more
doaj   +1 more source

A Robust Bio‐Supportive Hydrogel Patch for Full‐Thickness Repair of Gastroesophageal Defects

Advanced Science, EarlyView.
Gastroesophageal defect repair remains a formidable clinical challenge plagued by high leakage and life‐threatening complications. We develop a double‐disc, highly crystalline PVA‐based RBS hydrogel patch featuring suture‐free sealing, robust acid/enzyme resistance and mechanical durability.
Xingqi Song, Zhewei Shuai, Weiyan Sun, Liang Chen, Yiwei Shen, Jiateng Hu, Yuanqi Ma, Jie Luo, Meilin Huang, Yan Luo, Yunlang She, Guangdong Zhou, Chang Chen, Dong Lei   +13 more
wiley   +1 more source