Results 61 to 70 of about 835,919 (230)

Comparative analysis of the human and naked mole-rat (NMR) alpha 2-macroglobuolin sequence.

, 2015
Comparative analysis of the human and naked mole-rat (NMR) alpha 2-macroglobuolin sequence.
René Thieme (746422), Susanne Holtze (759119), Klaus Huse (11283), Susanne Kurz (759116), Michaela Morhart (759120), Tewodros Debebe (759118), Karol Szafranski (11960), Matthias Platzer (11284), Marlen Kolb (759117), Gerd Birkenmeier (365191), Thomas B. Hildebrandt (171299)   +10 more
core   +1 more source

Carrier‐Free Berberine/Nitidine Chloride Self‐Assembled Nanoparticles Induce Ferroptosis to Overcome Bortezomib Resistance in Multiple Myeloma

Advanced Science, EarlyView.
A schematic illustrating the fabrication process and ferroptosis‐mediated therapeutic mechanism of carrier‐free self‐assembled BBR/NC‐SAPs for overcoming bortezomib resistance in multiple myeloma. ABSTRACT Therapeutic relapse driven by bortezomib resistance represents a formidable clinical barrier in the management of multiple myeloma (MM).
Yiwen Lv, Shuang Liu, Hong Wu, Guiluan Li, Ying Rong, Guangchao Li, Yangmin Zhu, Qi Zhong, Ruiming Ou, Huijuan Shen, Zhi Liu, Jing Huang, Zhenwei Wang, Pei Lin, Qing Zhang, Guopan Yu, Zhao Yin   +16 more
wiley   +1 more source

MOF‐Derived Cu‐TiO2/Alginate Micromotors for Buoyancy‐Regulated 3D Motion

Advanced Science, EarlyView.
In this work, cyanobacteria‐inspired sodium alginate (SA)/Cu‐TiO2/Fe3O4 hydrogel micromotors generate and encapsulate O2 microvesicles upon light irradiation, enabling buoyancy‐mediated Z‐axis upward migration and surface enrichment at the light‐exposed water‐air surface.
Wei Zou, Qing Wu, Jiawei Lin, Kunchen Li, Yulong Ying, Josep Puigmartí‐Luis, Salvador Pané, Sheng Wang   +7 more
wiley   +1 more source

Marine predator inspired naked mole-rat algorithm for global optimization

, 2023
This paper proposes a hybrid version of marine predator algorithm (MPA) and naked mole-rat algorithm (NMRA) to aggregate the strengths of both algorithms.
Rohit Salgotra, Mirjalili, S, Gandomi, Amir H, Singh, S, Singh, U, Gandomi, AH, Singh, Urvinder, Singh, Supreet, Salgotra, R, Salgotra, Rohit, Mirjalili, Seyedali   +10 more
core   +2 more sources

Comment on 'Naked mole-rat mortality rates defy Gompertzian laws by not increasing with age'

eLife, 2019
Ruby et al. recently analyzed historical lifespan data on more than 3200 naked mole-rats, collected over a total observation period of about 38 years (Ruby et al., 2018). They report that mortality hazards do not seem to increase across the full range of
Philip Dammann, André Scherag, Nikolay Zak, Karol Szafranski, Susanne Holtze, Sabine Begall, Hynek Burda, Hans A Kestler, Thomas Hildebrandt, Matthias Platzer   +9 more
doaj   +1 more source

Discovery and Optimization of AMT‐676, a CDH17‐Targeting ADC for the Treatment of Advanced Gastrointestinal Cancers

Advanced Science, EarlyView.
AMT‐676 is a novel antibody‐drug conjugate targeting CDH17, an adhesion molecule uniquely exposed on gastrointestinal tumor surfaces. Engineered with an optimized exatecan payload, it demonstrates profound tumor regression and a robust bystander effect across diverse preclinical models.
Ying‐nan Wang, Dan‐yun Ruan, Jing Shi, Yue Huang, Hui Sheng, Ya‐ling Huang, Linjie Ma, Lijun Wang, Caiwei Chen, Yixuan Wang, Yue Zhang, Yi Shen, Qing Zhang, Jianjian Zhang, Yanfang Tang, Jin‐ling Zhang, Jia‐jia Hu, Chen‐yi Wu, Jia‐ying Chen, Xun Meng, Shu‐Hui Liu, Feng Wang   +21 more
wiley   +1 more source

Age is just a number

eLife, 2018
The naked mole rat defies the Gompertz law and shows no sign of increased mortality risk as it gets older.
Hiram Beltrán-Sánchez, Caleb Finch
doaj   +1 more source

Targeting LDHA Palmitoylation Sensitizes GBM to Chemoradiotherapy via Suppressing Palmitic Acid Induced Glycolytic Reprogramming

Advanced Science, EarlyView.
Mesenchymal GSCs preferentially uptake palmitic acid, thereby promoting ZDHHC12‐mediated LDHA palmitoylation. This modification enhances LDHA enzymatic activity, drives glycolytic reprogramming, and facilitates exosomal LDHA‐mediated TAM regulation.
Zijie Gao, Rongrong Zhao, Zheyuan Chen, Qingtong Wang, Huanyu Yang, Boyan Li, Yanhua Qi, Shulin Zhao, Jixing Zhao, Jiawei Qiu, Ziwen Pan, Zhe Han, Ruochuan Li, Huize Xia, Weijie Tang, Xing Guo, Ping Zhang, Hongyu Zhao, Xu Qian, Gang Li, Hao Xue   +20 more
wiley   +1 more source

Plasma oxidative stress in reproduction of two eusocial African mole-rat species, the naked mole-rat and the Damaraland mole-rat

Frontiers in Zoology, 2021
One of the most prominent life-history trade-offs involves the cost of reproduction. Oxidative stress has been proposed to be involved in this trade-off and has been associated with reduced life span.
Paul Juan Jacobs, Daniel William Hart, Nigel Charles Bennett   +2 more
doaj   +1 more source

Mechanisms of Temperature‐Dependent Hysteresis in Freestanding BaTiO3/MoS2 Heterostructures

Advanced Science, EarlyView.
Freestanding ferroelectric BaTiO3 membranes are combined with monolayer MoS2 into 2D field‐effect transistors. At room temperature they provide ultrahigh‐κ gating with steep subthreshold swing and minimal hysteresis. Upon cooling, strong ferroelectric switching produces two stable memory states with long retention times.
Thomas Pucher, Federico Mompeán, Víctor Rouco, Carlos León, Jacobo Santamaría, Carmen Munuera, Mar García‐Hernández, Andres Castellanos‐Gomez   +7 more
wiley   +1 more source