Subnormothermic Perfusion in the Isolated Rat Liver Preserves the Antioxidant Glutathione and Enhances the Function of the Ubiquitin Proteasome System. [PDF]
, 2016 The reduction of oxidative stress is suggested to be one of the main mechanisms to explain the benefits of subnormothermic perfusion against ischemic liver damage. In this study we investigated the early cellular mechanisms induced in isolated rat livers
Alva, Norma +4 more
core +4 more sources
Stress Resistance Screen in a Human Primary Cell Line Identifies Small Molecules That Affect Aging Pathways and Extend Caenorhabditis elegans' Lifespan. [PDF]
, 2020 Increased resistance to environmental stress at the cellular level is correlated with the longevity of long-lived mutants and wild-animal species. Moreover, in experimental organisms, screens for increased stress resistance have yielded mutants that are ...
Ang, Kenny Kean-Hooi +5 more
core +2 more sources
Investigation of the presence and antinociceptive function of muscarinic acetylcholine receptors in the African naked mole-rat (Heterocephalus glaber) [PDF]
, 2016 The present study investigated the cholinergic system in the African naked mole-rat (Heterocephalus glaber) with focus on the muscarinic acetylcholine receptor subtypes M(1) and M(4).
Abelson, Klas +4 more
core +1 more source
Naked mole-rat very-high-molecular-mass hyaluronan exhibits superior cytoprotective properties
Nature Communications, 2020 Naked mole rats are the longest-lived rodents and produce very-high-molecular-mass hyaluronan (vHMM-HA). Here the authors show that naked mole rat vHMM-HA is better at protecting mouse and human cells from cell cycle arrest and cell death, compared to ...
Masaki Takasugi +6 more
doaj +1 more source
Humans and dolphins: Decline and fall of adult neurogenesis [PDF]
, 2018 Pre-clinical research is carried out on animal models, mostly laboratory rodents, with the ultimate aim of translating the acquired knowledge to humans.
Bonfanti, Luca +2 more
core +2 more sources
High Autophagy in the Naked Mole Rat may Play a Significant Role in Maintaining Good Health
Cellular Physiology and Biochemistry, 2014 Background/Aims: The maximum lifespan of the naked mole rat is over 28.3 years, which exceeds that of any other rodent species, suggesting that age-related changes in its body composition and functionality are either attenuated or delayed in this ...
Shanmin Zhao +9 more
doaj +1 more source
The transcriptome of the bowhead whale Balaena mysticetus reveals adaptations of the longest-lived mammal [PDF]
, 2014 Mammals vary dramatically in lifespan, by at least two-orders of magnitude, but the molecular basis for this difference remains largely unknown. The bowhead whale Balaena mysticetus is the longest-lived mammal known, with an estimated maximal lifespan in
Bickham, John W. +8 more
core +4 more sources
Redox Biology, 2016 Hydrogen sulfide (H2S) is a gaseous signalling molecule involved in many physiological and pathological processes. There is increasing evidence that H2S is implicated in aging and lifespan control in the diet-induced longevity models.
Maja Dziegelewska +13 more
doaj +1 more source
, 2012 Naked mole rats are mouse-sized rodents that have become an important animal model in biomedical research. They play a unique mammalian role in behavioral and ecophysiological research of life underground. This chapter studies the general physiology, anatomy of organ systems, husbandry, and uses in research of the naked mole rats.
Buffenstein, Rochelle +3 more
openaire +1 more source
Anxious to see you: Neuroendocrine mechanisms of social vigilance and anxiety during adolescence. [PDF]
, 2020 Social vigilance is a behavioral strategy commonly used in adverse or changing social environments. In animals, a combination of avoidance and vigilance allows an individual to evade potentially dangerous confrontations while monitoring the social ...
Cassano G. B. +6 more
core +1 more source