Results 21 to 30 of about 835,919 (230)

Hypofunctional TrkA Accounts for the Absence of Pain Sensitization in the African Naked Mole-Rat

Cell Reports, 2016
The naked mole-rat is a subterranean rodent lacking several pain behaviors found in humans, rats, and mice. For example, nerve growth factor (NGF), an important mediator of pain sensitization, fails to produce thermal hyperalgesia in naked mole-rats. The
Damir Omerbašić, Ewan St. J. Smith, Mirko Moroni, Johanna Homfeld, Ole Eigenbrod, Nigel C. Bennett, Jane Reznick, Chris G. Faulkes, Matthias Selbach, Gary R. Lewin   +9 more
doaj   +1 more source

Naked mole-rat soft chirp analysis

, 2020
Revisited version of code related to the manuscript "Cultural transmission of vocal dialect in the naked mole-rat".
Grigorii Veviurko, Gary R. Lewin, Alison J. Barker   +2 more
core   +1 more source

Tumour resistance in induced pluripotent stem cells derived from naked mole-rats

Nature Communications, 2016
The naked mole-rat exhibits an exceptional resistance to cancer. Here, the authors show that induced pluripotent stem cells derived from the naked mole-rat lack teratoma-forming tumorigenicity due to a naked mole-rat-specific ARF-dependent tumour ...
Shingo Miyawaki, Yoshimi Kawamura, Yuki Oiwa, Atsushi Shimizu, Tsuyoshi Hachiya, Hidemasa Bono, Ikuko Koya, Yohei Okada, Tokuhiro Kimura, Yoshihiro Tsuchiya, Sadafumi Suzuki, Nobuyuki Onishi, Naoko Kuzumaki, Yumi Matsuzaki, Minoru Narita, Eiji Ikeda, Kazuo Okanoya, Ken-ichiro Seino, Hideyuki Saya, Hideyuki Okano, Kyoko Miura   +20 more
doaj   +1 more source

Socially Induced Infertility in Naked and Damaraland Mole-Rats: A Tale of Two Mechanisms of Social Suppression

Animals, 2022
The naked mole-rat (Heterocephalus glaber) and the Damaraland mole-rat (Fukomys damarensis) possess extreme reproductive skew with a single reproductive female responsible for reproduction.
Nigel C. Bennett, Christopher G. Faulkes, Cornelia Voigt   +2 more
doaj   +1 more source

The Mating Pattern of Captive Naked Mole-Rats Is Best Described by a Monogamy Model

Frontiers in Ecology and Evolution, 2022
Naked mole-rats form colonies with a single reproductively active female surrounded by subordinate workers. Workers perform offspring care, construction and defense of the burrow system, and food supply.
Karol Szafranski, Michaela Wetzel, Susanne Holtze, Ina Büntjen, Dietmar Lieckfeldt, Arne Ludwig, Arne Ludwig, Klaus Huse, Matthias Platzer, Thomas Hildebrandt   +9 more
doaj   +1 more source

β-catenin-promoted cholesterol metabolism protects against cellular senescence in naked mole-rat cells

Communications Biology, 2021
Woei-Yaw Chee et al. explore the molecular mechanisms of β-catenin involvement in cholesterol metabolism suppressing cellular senescence in naked mole-rat cells.
Woei-Yaw Chee, Yuriko Kurahashi, Junhyeong Kim, Kyoko Miura, Daisuke Okuzaki, Tohru Ishitani, Kentaro Kajiwara, Shigeyuki Nada, Hideyuki Okano, Masato Okada   +9 more
doaj   +1 more source

Hearing and Vocalizations in the Naked Mole-Rat [PDF]

, 2021
Since their discovery, naked mole-rats have been speaking to us. Early field studies noted their extensive vocalizations, and scientists who are fortunate enough to spend time with these creatures in the laboratory setting cannot help but notice their ...
Koch , U., Pyott , S., Lewin, Gary R., Gary R. Lewin, Lewin, G.R., Barker, Alison J., Alison J. Barker, Pyott, S.J., Ursula Koch, Sonja J. Pyott, Barker, A., Pyott, Sonja J.; id_orcid, Lewin , G., Barker, A.J., Koch, Ursula, Koch, U.   +15 more
core   +1 more source

Post-Translational Deimination of Immunological and Metabolic Protein Markers in Plasma and Extracellular Vesicles of Naked Mole-Rat (Heterocephalus glaber) [PDF]

, 2019
Naked mole-rats are long-lived animals which show unusual resistance to hypoxia, cancer and ageing. Protein deimination is an irreversible post-translational modification caused by the peptidylarginine deiminase (PADs) family of enzymes, which convert ...
Pamenter, Matthew E., Matthew E. Pamenter, Uysal Onganer, P., Huynh, Kenny W., Kenny W. Huynh, Pinar Uysal-Onganer, Sigrun Lange, Lange, S., Kraev, Igor, Igor Kraev, Lange, Sigrun, Uysal-Onganer, Pinar, Kraev, I.   +12 more
core   +1 more source

Characterization of a novel sensory modification in the naked mole-rat.

, 2004
Characterization of a novel sensory modification in the naked mole ...
Samuel D. Crish (7983188)
core   +4 more sources

Altered composition of liver proteasome assemblies contributes to enhanced proteasome activity in the exceptionally long-lived naked mole-rat. [PDF]

PLoS ONE, 2012
The longest-lived rodent, the naked mole-rat (Bathyergidae; Heterocephalus glaber), maintains robust health for at least 75% of its 32 year lifespan, suggesting that the decline in genomic integrity or protein homeostasis routinely observed during aging,
Karl A Rodriguez, Yael H Edrey, Pawel Osmulski, Maria Gaczynska, Rochelle Buffenstein   +4 more
doaj   +1 more source