Results 21 to 30 of about 13,887 (276)

Naked mole-rat [PDF]

Current Biology, 2008
What is it? Heterocephalus glaber — not exactly cute, but one of the most extraordinary creatures known to science (Figure 1Figure 1).Figure 1Cross-section showing digging chain of naked mole-rats (Photo: Justin O'Riain).View Large Image | View Hi-Res Image | Download PowerPoint SlideWhat's with the teeth? It looks strange because its lips close behind
openaire   +2 more sources

The Naked Mole Rat Genome Resource: facilitating analyses of cancer and longevity-related adaptations [PDF]

, 2014
Motivation: The naked mole rat (Heterocephalus glaber) is an exceptionally long-lived and cancer-resistant rodent native to East Africa. Although its genome was previously sequenced, here we report a new assembly sequenced by us with substantially higher
Alföldi, Jessica, Berlin, Aaron M., Church, George M., Craig, Thomas, de Magalhães, João Pedro, Di Palma, Federica, Gorbunova, Vera, Johnson, Jeremy, Keane, Michael, Lindblad-Toh, Kerstin, Seluanov, Andrei   +10 more
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Insights into long noncoding RNAs of naked mole rat (Heterocephalus glaber) and their potential association with cancer resistance [PDF]

, 2016
Additional file 4: Table S3.
Huan Wu, Jian-Jun Jiang, Le-Hua Cheng, Qing-Peng Kong, Yong-Han He   +4 more
core   +10 more sources

The Insulin-Like Growth Factor System in the Long-Lived Naked Mole-Rat. [PDF]

, 2015
Naked mole-rats (Heterocephalus glaber) (NMRs) are the longest living rodents known. They show negligible senescence, and are resistant to cancers and certain damaging effects associated with aging. The insulin-like growth factors (IGFs) have pluripotent
A Denley, C Davidge-Pitts, C Kenyon, C Lopez-Otin, CA Conover, CA Conover, CA Conover, CA Conover, Cheryl A. Conover, Chris G. Faulkes, D Byun, EB Kim, HB Boldt, HB Boldt, HB Boldt, J Azpurua, J Brown, J Whittaker, KT Davies, LA Bach, LS Laursen, M Katic, M Keane, M Keyhanfar, M Pollak, MA Delaney, Malene Brohus, Matthew S Gill, Michael T. Overgaard, MW Pfaffl, P Cohen, P Monget, R Buffenstein, R Buffenstein, RC Baxter, SL Harstad, SM Firth, SN Austad, T Sitar, TE Adams, V Gorbunova, V Hwa, Vera Gorbunova, VN Anisimov, X Tian, YH Edrey, ZT Resch   +46 more
core   +7 more sources

Accuracy of mobile digital teledermoscopy for skin self-examinations in adults at high risk of skin cancer: an open-label, randomised controlled trial [PDF]

, 2020
Background: Skin self-examinations supplemented with mobile teledermoscopy might improve early detection of skin cancers compared with naked-eye skin self-examinations.
Avilés-Izquierdo, Baade, Berwick, Boyce, Chambers, Chao, Djaja, Genders, Hamidi, Janda, Janda, Janda, Kandel, King, Kroemer, Li, Luttrell, Manahan, Markun, Morze, Pike, Rat, Robinson, Tschandl, Venables, Wu   +25 more
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Molecular adaptation of telomere associated genes in mammals [PDF]

, 2013
Background: Placental mammals display a huge range of life history traits, including size, longevity, metabolic rate and germ line generation time. Although a number of general trends have been proposed between these traits, there are exceptions that ...
Donoghue, MTA, Loughran, NB, Mc Cartney, AM, Morgan, CC, O'Connell, MJ, Spillane, C, Teeling, EC   +6 more
core   +3 more sources

Hypofunctional TrkA Accounts for the Absence of Pain Sensitization in the African Naked Mole-Rat

Cell Reports, 2016
The naked mole-rat is a subterranean rodent lacking several pain behaviors found in humans, rats, and mice. For example, nerve growth factor (NGF), an important mediator of pain sensitization, fails to produce thermal hyperalgesia in naked mole-rats. The
Damir Omerbašić, Ewan St. J. Smith, Mirko Moroni, Johanna Homfeld, Ole Eigenbrod, Nigel C. Bennett, Jane Reznick, Chris G. Faulkes, Matthias Selbach, Gary R. Lewin   +9 more
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RNA sequencing reveals differential expression of mitochondrial and oxidation reduction genes in the long-lived naked mole-rat when compared to mice.

PLoS ONE, 2011
The naked mole-rat (Heterocephalus glaber) is a long-lived, cancer resistant rodent and there is a great interest in identifying the adaptations responsible for these and other of its unique traits.
Chuanfei Yu, Yang Li, Andrew Holmes, Karol Szafranski, Chris G Faulkes, Clive W Coen, Rochelle Buffenstein, Matthias Platzer, João Pedro de Magalhães, George M Church   +9 more
doaj   +1 more source

Novel treatment strategies for chronic kidney disease: insights from the animal kingdom [PDF]

, 2018
Many of the >2 million animal species that inhabit Earth have developed survival mechanisms that aid in the prevention of obesity, kidney disease, starvation, dehydration and vascular ageing; however, some animals remain susceptible to these ...
Arnold, Walter, Johnson, Richard J., Kuro-o, Makoto, Lanaspa, Miguel, Painer, Johanna, Ruf, Thomas, Shiels, Paul G., Stenvinkel, Peter   +7 more
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β-catenin-promoted cholesterol metabolism protects against cellular senescence in naked mole-rat cells

Communications Biology, 2021
Woei-Yaw Chee et al. explore the molecular mechanisms of β-catenin involvement in cholesterol metabolism suppressing cellular senescence in naked mole-rat cells.
Woei-Yaw Chee, Yuriko Kurahashi, Junhyeong Kim, Kyoko Miura, Daisuke Okuzaki, Tohru Ishitani, Kentaro Kajiwara, Shigeyuki Nada, Hideyuki Okano, Masato Okada   +9 more
doaj   +1 more source