Animals, 2022 The naked mole-rat (Heterocephalus glaber) and the Damaraland mole-rat (Fukomys damarensis) possess extreme reproductive skew with a single reproductive female responsible for reproduction.
Nigel C. Bennett +2 more
doaj +1 more source
Genome Stability Maintenance in Naked Mole-Rat [PDF]
Acta Naturae, 2017 The naked mole-rat (Heterocephalus glaber) is one of the most promising models used to study genome maintenance systems, including the effective repair of damage to DNA. The naked mole-rat is the longest lived rodent species, which is extraordinarily resistant to cancer and has a number of other unique phenotypic traits.
I O, Petruseva +2 more
openaire +3 more sources
Tumour resistance in induced pluripotent stem cells derived from naked mole-rats
Nature Communications, 2016 The naked mole-rat exhibits an exceptional resistance to cancer. Here, the authors show that induced pluripotent stem cells derived from the naked mole-rat lack teratoma-forming tumorigenicity due to a naked mole-rat-specific ARF-dependent tumour ...
Shingo Miyawaki +20 more
doaj +1 more source
The Mating Pattern of Captive Naked Mole-Rats Is Best Described by a Monogamy Model
Frontiers in Ecology and Evolution, 2022 Naked mole-rats form colonies with a single reproductively active female surrounded by subordinate workers. Workers perform offspring care, construction and defense of the burrow system, and food supply.
Karol Szafranski +9 more
doaj +1 more source
The Naked Mole-Rat: An Unusual Organism with an Unexpected Latent Potential for Increased Intelligence? [PDF]
, 2019 Naked mole-rats are eusocial, hairless mammals that are uniquely adapted to their harsh, low-oxygen subsurface habitat. Although their encephalization quotient, a controversial marker of intelligence, is low, they exhibit many features considered tell ...
Schulze-Makuch, Dirk
core +1 more source
Absence of CD59 in guinea pigs: Analysis of the Cavia porcellus genome suggests the evolution of a CD59 pseudogene [PDF]
, 2018 CD59 is a membrane-bound regulatory protein that inhibits the assembly of the terminal membrane attack complex (C5b-9) of complement. From its original discovery in humans almost 30 years ago, CD59 has been characterized in a variety of species, from ...
Boshra, Hani +4 more
core +1 more source
Altered composition of liver proteasome assemblies contributes to enhanced proteasome activity in the exceptionally long-lived naked mole-rat. [PDF]
PLoS ONE, 2012 The longest-lived rodent, the naked mole-rat (Bathyergidae; Heterocephalus glaber), maintains robust health for at least 75% of its 32 year lifespan, suggesting that the decline in genomic integrity or protein homeostasis routinely observed during aging,
Karl A Rodriguez +4 more
doaj +1 more source
Dual-function injectable angiogenic biomaterial for the repair of brain tissue following stroke. [PDF]
, 2018 Stroke is the primary cause of disability due to the brain's limited ability to regenerate damaged tissue. After stroke, an increased inflammatory and immune response coupled with severely limited angiogenesis and neuronal growth results in a stroke ...
Carmichael, S Thomas +3 more
core +1 more source
Naked Mole-Rats Demonstrate Profound Tolerance to Low Oxygen, High Carbon Dioxide, and Chemical Pain
Animals, 2023 Naked mole-rats (Heterocephalus glaber) are very unusual among subterranean mammals in that they live in large colonies and are extremely social, spending large amounts of time gathered together in underground nests more than a meter below the surface ...
Vince G. Amoroso +3 more
doaj +1 more source
Functional neurokinin and NMDA receptor activity in an animal naturally lacking substance P: the naked mole-rat. [PDF]
PLoS ONE, 2010 Naked mole-rats are extremely unusual among mammals in that their cutaneous C-fibers lack the neuropeptide Substance P (SP). In other mammals, SP plays an important role in nociception: it is released from C-fibers onto spinal neurons where it ...
Antje Brand +3 more
doaj +1 more source