Results 11 to 20 of about 835,919 (230)

Functional neurokinin and NMDA receptor activity in an animal naturally lacking substance P: the naked mole-rat. [PDF]

PLoS ONE, 2010
Naked mole-rats are extremely unusual among mammals in that their cutaneous C-fibers lack the neuropeptide Substance P (SP). In other mammals, SP plays an important role in nociception: it is released from C-fibers onto spinal neurons where it ...
Antje Brand, Ewan St J Smith, Gary R Lewin, Thomas J Park   +3 more
doaj   +8 more sources

Naked mole-rat macrophage polarization [PDF]

Медицинская иммунология
The naked mole-rat (NMR) is a unique long-lived rodent with low cancer incidence. Understanding the molecular mechanisms that NMR evolved to control aging and tumorigenesis is important for biomedicine.
E. A. Gorshkova, S. K. Purtova, E. M. Dvorianinova, M. Yu. Vyssokikh, S. A. Nedospasov   +4 more
doaj   +2 more sources

Absence of histamine-induced itch in the African naked mole-rat and "rescue" by Substance P [PDF]

Molecular Pain, 2010
Recent research has proposed a pathway in which sensory neurons expressing the capsaicin activated ion channel TRPV1 are required for histamine-induced itch and subsequent scratching behavior.
Lewin Gary R, Blass Gregory RC, Smith Ewan, Park Thomas J   +3 more
doaj   +3 more sources

Naked mole-rats have distinctive cardiometabolic and genetic adaptations to their underground low-oxygen lifestyles [PDF]

Nature Communications
The naked mole-rat Heterocephalus glaber is a eusocial mammal exhibiting extreme longevity (37-year lifespan), extraordinary resistance to hypoxia and absence of cardiovascular disease.
Chris G. Faulkes, Thomas R. Eykyn, Jan Lj. Miljkovic, James D. Gilbert, Rebecca L. Charles, Hiran A. Prag, Nikayla Patel, Daniel W. Hart, Michael P. Murphy, Nigel C. Bennett, Dunja Aksentijevic   +10 more
doaj   +13 more sources

Blunted behavioral and c Fos responses to acidic fumes in the African naked mole-rat. [PDF]

PLoS ONE, 2012
Acidosis in the skin triggers activation of pain pathways and behaviors indicative of pain in vertebrates. The exception is the naked mole-rat, the only known vertebrate to show physiological and behavioral insensitivity to acid pain in the skin.
Pamela Colleen LaVinka, Thomas J Park
doaj   +4 more sources

Sequence alignment of naked mole rat and human calmodulins.

, 2021
NMR, naked mole rat. Acidic residues are highlighted in red, basic in blue. Cysteines are highlighted in yellow.
Stephanie A. Hill (11378779), Xuelei Ni (11378776), Lydia R. Wade (11378782), Aidan P. Keelaghan (11378785), Scott J. Nowak (11378773), Jonathan L. McMurry (779952), William R. Clark (2903765), Daniel P. Morris (449127), Schuyler B. Gentry (11378770)   +8 more
core   +1 more source

Comparative analysis of thyroid hormone systems in rodents with subterranean lifestyle

Scientific Reports, 2023
African mole-rats are subterranean rodents inhabiting underground burrows. This habitat entails risks of overheating, hypoxia, and scarce food availability.
Patricia Gerhardt, Sabine Begall, Caroline Frädrich, Kostja Renko, Thomas B. Hildebrandt, Susanne Holtze, Alexandra Heinrich, Arne Sahm, Xheni Meci, Josef Köhrle, Eddy Rijntjes, Yoshiyuki Henning   +11 more
doaj   +1 more source

Blunted neuronal calcium response to hypoxia in naked mole-rat hippocampus. [PDF]

PLoS ONE, 2012
Naked mole-rats are highly social and strictly subterranean rodents that live in large communal colonies in sealed and chronically oxygen-depleted burrows.
Bethany L Peterson, John Larson, Rochelle Buffenstein, Thomas J Park, Christopher P Fall   +4 more
doaj   +1 more source

The Naked Mole Rat Genome Resource: facilitating analyses of cancer and longevity-related adaptations [PDF]

, 2014
Motivation: The naked mole rat (Heterocephalus glaber) is an exceptionally long-lived and cancer-resistant rodent native to East Africa. Although its genome was previously sequenced, here we report a new assembly sequenced by us with substantially higher
Alföldi, Jessica, Berlin, Aaron M., de Magalhães, João Pedro, Keane, Michael, Seluanov, Andrei, Di Palma, Federica, Church, George, Johnson, Jeremy, Gorbunova, Vera, Lindblad-Toh, Kerstin, Craig, Thomas, Berlin, Aaron M, Church, George M, Lindblad-Toh, Kerstin,   +13 more
core   +1 more source

Acid and inflammatory sensitisation of naked mole-rat colonic afferent nerves

Molecular Pain, 2020
Acid sensing in the gastrointestinal tract is required for gut homeostasis and the detection of tissue acidosis caused by ischaemia, inflammation and infection.
James RF Hockley, Katie H Barker, Toni S Taylor, Gerard Callejo, Zoe M Husson, David C Bulmer, Ewan St. J Smith   +6 more
doaj   +1 more source