Results 11 to 20 of about 13,887 (276)

Selective inflammatory pain insensitivity in the African naked mole-rat (Heterocephalus glaber).

PLoS Biology, 2008
In all mammals, tissue inflammation leads to pain and behavioral sensitization to thermal and mechanical stimuli called hyperalgesia. We studied pain mechanisms in the African naked mole-rat, an unusual rodent species that lacks pain-related ...
Thomas J Park, Ying Lu, René Jüttner, Ewan St J Smith, Jing Hu, Antje Brand, Christiane Wetzel, Nevena Milenkovic, Bettina Erdmann, Paul A Heppenstall, Charles E Laurito, Steven P Wilson, Gary R Lewin   +12 more
doaj   +3 more sources

Transformation of naked mole-rat cells [PDF]

Nature, 2020
Hadi, Fazal, Kulaberoglu, Yavuz, Lazarus, Kyren A, Bach, Karsten, Ugur, Rosemary, Beattie, Paul, Smith, Ewan St John, Khaled, Walid T   +7 more
openaire   +4 more sources

Naked Mole Rat Induced Pluripotent Stem Cells and Their Contribution to Interspecific Chimera

Stem Cell Reports, 2017
Summary: Naked mole rats (NMRs) are exceptionally long-lived, cancer-resistant rodents. Identifying the defining characteristics of these traits may shed light on aging and cancer mechanisms.
Sang-Goo Lee, Aleksei E. Mikhalchenko, Sun Hee Yim, Alexei V. Lobanov, Jin-Kyu Park, Kwang-Hwan Choi, Roderick T. Bronson, Chang-Kyu Lee, Thomas J. Park, Vadim N. Gladyshev   +9 more
doaj   +3 more sources

Increased hyaluronan by naked mole-rat Has2 improves healthspan in mice. [PDF]

Nature, 2023
Zhang Z, Tian X, Lu JY, Boit K, Ablaeva J, Zakusilo FT, Emmrich S, Firsanov D, Rydkina E, Biashad SA, Lu Q, Tyshkovskiy A, Gladyshev VN, Horvath S, Seluanov A, Gorbunova V.   +15 more
europepmc   +2 more sources

Social structure predicts genital morphology in African mole-rats. [PDF]

PLoS ONE, 2009
BACKGROUND:African mole-rats (Bathyergidae, Rodentia) exhibit a wide range of social structures, from solitary to eusocial. We previously found a lack of sex differences in the external genitalia and morphology of the perineal muscles associated with the
Marianne L Seney, Diane A Kelly, Bruce D Goldman, Radim Sumbera, Nancy G Forger   +4 more
doaj   +1 more source

Naked mole rat cells display more efficient DNA excision repair and higher resistance to toxic impacts than mouse cells

BIO Web of Conferences, 2020
Naked mole rat is the long-lived and tumor-resistant rodent. Naked mole rat possesses multiple adaptations that may contribute to longevity and cancer-resistance.
Evdokimov Alexey, Petruseva Irina, Popov Aleksei, Koval Olga, Lavrik Olga   +4 more
doaj   +1 more source

Protracted neuronal maturation in a long-lived, highly social rodent.

PLoS ONE, 2022
Naked mole-rats are a long-lived rodent species (current lifespan >37 years) and an increasingly popular biomedical model. Naked mole-rats exhibit neuroplasticity across their long lifespan.
Mariela Faykoo-Martinez, Troy Collins, Diana Peragine, Manahil Malik, Fiza Javed, Matthew Kolisnyk, Justine Ziolkowski, Imaan Jeewa, Arthur H Cheng, Christopher Lowden, Brittany Mascarenhas, Hai-Ying Mary Cheng, Melissa M Holmes   +12 more
doaj   +2 more sources

Naked Mole‐Rats: Blind, Naked, and Feeling No Pain [PDF]

The Anatomical Record, 2018
ABSTRACTAround the world and across taxa, subterranean mammals show remarkable convergent evolution in morphology (e.g., reduced external ears, small eyes, shortened limbs and tails). This is true of sensory systems as well (e.g., loss of object vision and high frequency hearing).
Brigitte M. Browe, Emily N. Vice, Thomas J. Park   +2 more
openaire   +2 more sources

Comparative analysis of thyroid hormone systems in rodents with subterranean lifestyle

Scientific Reports, 2023
African mole-rats are subterranean rodents inhabiting underground burrows. This habitat entails risks of overheating, hypoxia, and scarce food availability.
Patricia Gerhardt, Sabine Begall, Caroline Frädrich, Kostja Renko, Thomas B. Hildebrandt, Susanne Holtze, Alexandra Heinrich, Arne Sahm, Xheni Meci, Josef Köhrle, Eddy Rijntjes, Yoshiyuki Henning   +11 more
doaj   +1 more source

Blunted neuronal calcium response to hypoxia in naked mole-rat hippocampus. [PDF]

PLoS ONE, 2012
Naked mole-rats are highly social and strictly subterranean rodents that live in large communal colonies in sealed and chronically oxygen-depleted burrows.
Bethany L Peterson, John Larson, Rochelle Buffenstein, Thomas J Park, Christopher P Fall   +4 more
doaj   +1 more source