Results 71 to 80 of about 13,887 (276)

Gene losses may contribute to subterranean adaptations in naked mole-rat and blind mole-rat

BMC Biology, 2022
Background Naked mole-rats (Heterocephalus glaber, NMRs) and blind mole-rats (Spalax galili, BMRs) are representative subterranean rodents that have evolved many extraordinary traits, including hypoxia tolerance, longevity, and cancer resistance ...
Zhizhong Zheng, Rong Hua, Guoqiang Xu, Hui Yang, Peng Shi   +4 more
doaj   +1 more source

Reply to: Transformation of naked mole-rat cells

Nature, 2020
It has been independently demonstrated by us and Liang et al. that naked mole-rat (NMR) cells are more resistant to SV40LT and H-RasV12-induced transformation than mouse cells. In the accompanying comment, Hadi et al. argued that NMR cells and mouse cells are equally susceptible to oncogenic transformation by SV40LT and H-RasV12.
Jing Zhao, Xiao Tian, Yabing Zhu, Zhihui Zhang, Elena Rydkina, Yongxian Yuan, Hongyun Zhang, Bhaskar Roy, Adam Cornwell, Eviatar Nevo, Xiaoxiao Shang, Runyue Huang, Karsten Kristiansen, Andrei Seluanov, Xiaodong Fang, Vera Gorbunova   +15 more
openaire   +4 more sources

Hypothesis of the basic biological sense of cancer revisited: a putative explanation of Peto's paradox [PDF]

, 2017
The conventional interpretation of cancer, summarized in the unified genetic theory of carcinogenesis, assumes that the malignant cell is the anatomical and physiological unit of cancer.
Bustuoabad, Oscar David, Ruggiero, Raul Alejandro   +1 more
core  

Targeting Peptostreptococcus anaerobius with an Iron‐Based Nanozyme Reverses Ferroptosis Resistance and Enhances Antitumor Immunity in Colorectal Cancer

Advanced Science, EarlyView.
An iron‐based nanozyme selectively eliminates intratumoral P. anaerobius while catalytically generating ROS to induce ferroptosis, synergistically suppressing colorectal cancer growth and activating anti‐tumor immunity through immunogenic cell death. ABSTRACT The intratumoral microbiota is a critical determinant of therapeutic outcomes in colorectal ...
Yinghao Cao, Jun Wang, Hanwenchen Wang, Xiang Sun, Fang Fang, Shiying Li, Jianping Liu, Changrong Shi, Pengyuan Qi, Jianhua Zou, Xiaoyuan Chen, Kailin Cai   +11 more
wiley   +1 more source

Translation of Cellular Senescence to Novel Therapeutics: Insights From Alternative Tools and Models

Frontiers in Aging, 2022
Increasing chronological age is the greatest risk factor for human diseases. Cellular senescence (CS), which is characterized by permanent cell-cycle arrest, has recently emerged as a fundamental mechanism in developing aging-related pathologies.
Nurcan Inci, Dilanur Kamali, Erdogan Oguzhan Akyildiz, Eda Tahir Turanli, Eda Tahir Turanli, Perinur Bozaykut, Perinur Bozaykut   +6 more
doaj   +1 more source

Hierarchical Targeting of TREM2+ Myeloid Cells via Acid‐Triggered OMVs Reprogram Immunosuppression and Suppress Osteolysis in Bone‐Metastatic TNBC

Advanced Science, EarlyView.
This study developed a hierarchical targeting nanoplatform, siTREM2@ETP‐PEOz‐OMVs, against triple‐negative breast cancer (TNBC) bone metastasis. It precisely delivers therapeutic siTREM2 to monocytes/macrophages within the metastatic niche. This intervention dually regulates cell fate: reprogramming immunosuppressive macrophages and inhibiting ...
Fanglu Chen, Yucheng Xue, Xiao Ma, Liang Chen, Zhenxuan Shao, Hangxiang Sun, Haochen Mou, Fangqian Wang, Zilong Li, Yechao Shen, Zhaoming Ye, Xiaohua Yu, Shengdong Wang   +12 more
wiley   +1 more source

Spectroscopic Analysis of the Extracellular Matrix Hierarchical Structure in Naked Mole-Rat Skin

Gels
Naked mole-rats are extremely long-lived rodents with a lifespan of up to 40 years, during which cellular and tissue aging is rarely observed. In this study, we analyzed the extracellular matrix (ECM) of naked mole-rat skin at the molecular level to ...
Tetsuya Adachi, Hayata Imamura, Risa Tamagawa-Mineoka, Toyonari Yaji, Makoto Kawano, Shigenori Itsuzaki, Keiji Adachi, Fumishige Oseko, Shunichi Shibata, Satoru Shindo, Sachiro Kakinoki, Osam Mazda, Toshihisa Kawai, Kyoko Miura, Wenliang Zhu, Giuseppe Pezzotti   +15 more
doaj   +1 more source

Comparative analysis of bats and rodents’ genomes suggests a relation between non-LTR retrotransposons, cancer incidence, and ageing

Scientific Reports, 2023
The presence in nature of species showing drastic differences in lifespan and cancer incidence has recently increased the interest of the scientific community.
Marco Ricci, Valentina Peona, Alessio Boattini, Cristian Taccioli   +3 more
doaj   +1 more source

The “Naked Truth” [PDF]

Veterinary Pathology, 2016
Keywords: aging ; animal models ; cancer ; Heterocephalus glaber ; longevity ; naked mole-rats ; neoplasia ; tumor Reference EPFL-ARTICLE-219755doi:10.1177/0300985816638431View record in Web of Science Record created on 2016-07-19, modified on 2017-05 ...
A, Piersigilli, D K, Meyerholz
openaire   +2 more sources

The accelerating influence of humans on mammalian macroecological patterns over the late Quaternary [PDF]

, 2019
The transition of hominins to a largely meat-based diet ~1.8 million years ago led to the exploitation of other mammals for food and resources. As hominins, particularly archaic and modern humans, became increasingly abundant and dispersed across the ...
Elliott Smith, Rosemary E., Lyons, S. Kathleen, Payne, Jonathan L., Smith, Felisa A., Villaseñor, Amelia   +4 more
core   +1 more source