Results 101 to 110 of about 835,919 (230)
Advanced Science, EarlyView.Accurately detecting diverse same‐locus insertions or deletions (indels) remains challenging. This study reveals the mismatch‐tolerance profile of LwaCas13a and establishes CRISPR‐Scan, which uses a single crRNA to detect multiple same‐locus indels. The one‐pot assay detects nucleophosmin 1 (NPM1) mutant allele frequencies down to 0.01%, agrees with ...
Linlin Bai +13 more
wiley +1 more source
Advanced Science, EarlyView.A scalable laser‐assisted surface patterning method regulates zinc ion flux and promotes lateral epitaxial growth for stable aqueous batteries. Periodic micro‐holes effectively minimize interfacial resistance and reconstruct the zinc texture to favor the compact (002) basal plane. This structured anode suppresses both dendrite propagation and parasitic
Suyeon Kim +10 more
wiley +1 more source
Angewandte Chemie, EarlyView.PQB‐4, a fluorescent small‐molecule ligand that targets c‐MYC DNA G‐quadruplexes (G4s), showed marked synergy with gemcitabine in resistant PANC‐1 cells (CI = 0.027). In vivo, the ligand reduced tumor weight by 44% in a PANC‐1 xenograft model. These results highlight the therapeutic potential of c‐MYC DNA G4‐targeting ligands for treating gemcitabine ...
Bo‐Xin Zheng +10 more
wiley +2 more sources
Advanced Science, EarlyView.A biomimetic ultrasound‐responsive piRNA delivery nanoparticle platform (piR‐NPs) enables targeted delivery and ultrasound (US)‐triggered release of piR‐1873 in infarcted myocardium. The released piR‐1873 suppresses Usp2‐mediated RIP1/RIP3/MLKL necroptosis, reduces myocardial injury and fibrosis, and promotes cardiac functional recovery, providing a ...
Yajun Zhang +10 more
wiley +1 more source
Building a Better Naked-mole rat Trap MEMS 411- Senior Design Course [PDF]
, 2016 In this paper, we design, analyze, test, and construct an improved naked mole rat trap for Prof.
Middleton, Lance +2 more
core
Advanced Science, EarlyView.This study identifies ZMIZ2 as a therapeutic target for docetaxel‐resistant triple‐negative breast cancer, sustaining cancer stemness‐associated properties and docetaxel resistance. ZMIZ2 upregulation enhances DUX4‐mediated LGR5 activation through the SWI/SNF components BRG1 and BAF57.
Xueting Gan +9 more
wiley +1 more source
Advanced Science, EarlyView.The study integrates density functional theory with radiochemical and biological validation to compare DOTA‐, PSC‐, and DOTAM‐based chelator‐conjugates for 203Pb/212Pb theranostic applications. Distinct differences in metal coordination, electrostatic properties, conformational flexibility, cellular uptake, biodistribution, and dosimetry are identified
Jeongyun Kim +12 more
wiley +1 more source
In Vivo CRISPR Screen Identifies RPS19 as an Immunotherapy Target in Hepatocellular Carcinoma
Advanced Science, EarlyView.By employing in vivo CRISPR functional screening, we identify ribosomal protein RPS19 as a pivotal mediator driving immune evasion in hepatocellular carcinoma, wherein tumor‑released RPS19 binds C5aR1 on tumor‑associated macrophages to initiate downstream immunosuppressive signaling; SP94‑peptide‑modified SNPSS nanoparticles deliver Cas9/sgRPS19 ...
Lei He +20 more
wiley +1 more source
Naked Mole Rats: Their Extraordinary Sensory World
, 2010 In 1981, Jennifer Jarvis published her remarkable finding of a subterranean mammal – the naked mole-rat – that lived like a termite. A typical colony of naked mole-rats has a dominant breeding queen and scores of nonbreeding adult helpers.
Buffenstein, R. +5 more
core +1 more source