Results 151 to 160 of about 3,459 (225)

NALORPHINE, A POTENT ANALGESIC IN MAN

The Journal of Pharmacology and Experimental Therapeutics, 1956
A S, KEATS, J, TELFORD
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THE ANALGESIC EFFECTIVENESS OF NALORPHINE AND NALORPHINE-MORPHINE COMBINATIONS IN MAN

The Journal of Pharmacology and Experimental Therapeutics, 1954
L, LASAGNA, H K, BEECHER
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NALORPHINE (N-ALLYLNORMORPHINE)

A.M.A. Archives of Internal Medicine, 1954
HISTORY THE HISTORY of N-substituted allyl compounds of the morphine series is both fascinating and instructive. Pohl, 1 almost 40 years ago, became interested in the work of a colleague named Piazza. The latter worker had found allyl compounds to be, in general, irritating to tissues and (under some circumstances) productive of stimulant effects on ...
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NALORPHINE (NALLINE) ANTAGONISM TO RACEMORPHAN (DROMORAN) INTOXICATION

JAMA: The Journal of the American Medical Association, 1953
Experiments with laboratory animals indicate that nalorphine (Nalline) is effective in antagonizing most of the effects of morphine, codeine, dihydromorphinone (Dilaudid), metopon, methadone, and meperidine (Demerol). Successful clinical use of nalorphine to antagonize the respiratory depression caused by morphine, dihydromorphinone, methadone, and ...
E F, DOMINO, E W, PELIKAN, E F, TRAUT
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The interaction of morphine and nalorphine on respiration

Clinical Pharmacology & Therapeutics, 1968
A study was carried out in volunteers to determine the relative potency as respiratory depressants of nalorphine and morphine and their interaction when administered together. The relative potency of nalorphine when compared to morphine was found to be 0.74 (13.5 mg. nalorphine ≎ 10 mg. morphine).
J W, Bellville, G, Fleischli
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NALORPHINE HYDROCHLORIDE, N.N.R. ("NALLINE HYDROCHLORIDE")

Annals of Internal Medicine, 1954
Excerpt Although morphine has been one of the most important drugs in the physician's armamentarium for many years, its serious disadvantages have always been recognized.
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Pentazocine, cyclazocine, and nalorphine as discriminative stimuli

Psychopharmacology, 1977
Pentazocine, cyclazocine, and nalorphine are narcotic antagonists that also have analgesic activity of their own. The present investigation compared the stimulus properties of these three drugs in rats. Each drug was used as a discriminative stimulus for a separate group of rats.
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Antibody-bound nalorphine released on challenge with morphine

Nature, 1975
IN mice treated with morphine coupled to bovine serum albumin (BSA), antibodies are formed which bind injected morphine and reduce its analgesic effect1. The possible therapeutic implications of this observation have been speculated on2, but a calculation of the number of morphine-binding ligands of a satisfactory antibody titre gives a theoretical ...
L M, Gunne, J, Jonsson, L, Paalzow, E, Anggard   +3 more
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Nalorphine-like properties of some 2,3-dimethyl-3-arylpiperidines

Journal of Medicinal Chemistry, 1978
A number of N-substituted 2,3-dimethyl-3-arylpiperidines having an m- or p-arylhydroxyl were prepared and evaluated for analgesic agonist and antagonist properties. The diastereomeric N-allyl and N-cyclopropylmethyl derivatives behaved as pure potent antagoinists.
M A, Iorio, A F, Casy
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Sigma effects of nalorphine in the chronic spinal dog

Drug and Alcohol Dependence, 1976
The effects of graded doses of nalorphine and morphine were studied in nondependent chronic spinal dogs. Morphine and low doses of nalorphine produced behavioral changes characterized by indifference, whereas the largest dose of nalorphine produced canine delirium indistinguishable from that produced by SKF-10, 047 or cyclazocine.
P E, Gilbert, W R, Martin
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