Results 131 to 140 of about 2,595 (197)

Physiological disposition and biotransformation of [allyl-1', 3' - 14C naloxone in the rat and some comparative observations on nalorphine.

Journal of Pharmacology and Experimental Therapeutics, 1976
A sensitive method is described for the estimation of [14C]naloxone in biological materials. After a 1 mg/kg s.c. dose of [14C]naloxone to male Wistar rats, mean peak levels of drug in brain (506 ng/g) and plasma (119 ng/ml) were attained within 15 ...
A. Misra, Pontani Rb, N. L. Vadlamani, S. Mulé   +3 more
semanticscholar   +1 more source

Quantitative studies of the antagonism of morphine by nalorphine and naloxone.

Journal of Pharmacology and Experimental Therapeutics, 1969
The in vivo equivalents of pA2 values for morphine-naloxone for antagonism of analgesia and intestinal inhibition in mice were 7.01 and 6.60, respectively.
A. Takemori, H. Kupferberg, J. W. Miller
semanticscholar   +1 more source

Nalorphine-induced abstinence syndrome in morphine-tolerant albino rats.

Journal of Pharmacology and Experimental Therapeutics, 1956
Nalorphine hydrochloride administered subcutaneously in a dose of 10 mgm./ kgm. to rats tolerant to 100 mgm./kgm. of morphine sulfate, administered subcutaneously twice daily, induces an "abstinence syndrome".
Ş. Kaymakçalan, L. A. Woods
semanticscholar   +1 more source

ANALGESIC EFFECTS IN MONKEYS OF MORPHINE, NALORPHINE, AND A BENZOMORPHAN NARCOTIC ANTAGONIST.

Journal of Pharmacology and Experimental Therapeutics, 1964
The comparative analgesic actions of morphine, nalorphine, and a benzomorphan narcotic antagonist (Win 20,740) were assessed in monkeys by means of a titration schedule.
B. Weiss, V. Laties
semanticscholar   +1 more source

Discriminative stimulus properties of nalorphine in the rhesus monkeys.

Journal of Pharmacology and Experimental Therapeutics, 1983
The discriminative stimulus properties of nalorphine were studied in rhesus monkeys trained to discriminate i.m. injections of nalorphine (1 mg/kg) from saline.
A. H. Tang, R. Code
semanticscholar   +1 more source

NALORPHINE (N-ALLYLNORMORPHINE)

A.M.A. Archives of Internal Medicine, 1954
HISTORY THE HISTORY of N-substituted allyl compounds of the morphine series is both fascinating and instructive. Pohl, 1 almost 40 years ago, became interested in the work of a colleague named Piazza. The latter worker had found allyl compounds to be, in general, irritating to tissues and (under some circumstances) productive of stimulant effects on ...
openaire   +2 more sources

The inhibitory action of nalorphine on the enzymatic N-demethylation of narcotic drugs.

Journal of Pharmacology and Experimental Therapeutics, 1957
Nalorphine and its analogues inhibit the N-demethylation of morphine and other narcotic drugs in rat-liver microsomal preparations. N-substituted normorphine derivatives with a 3-carbon chain linked to the nitrogen atom are the most potent inhibitors ...
J. Axelrod, J. Cochin
semanticscholar   +1 more source

Studies on cellular adaptation to morphine and its reversal by nalorphine in cerebral cortical slices of rats.

Journal of Pharmacology and Experimental Therapeutics, 1962
Cellular adaptation to morphine using cerebral cortical slices of rats can he acquired within a week of morphinization to the rats and can be lost within a week after abrupt withdrawal from the narcotic.
A. Takemori
semanticscholar   +1 more source

THE EFFECTS OF MORPHINE, PENTOBARBITAL, PENTAZOCINE AND NALORPHINE ON BIOELECTRICAL POTENTIALS EVOKED IN THE BRAIN STEM OF THE CAT BY ELECTRICAL STIMULATION OF THE TOOTH PULP.

Journal of Pharmacology and Experimental Therapeutics, 1964
The purpose of this investigation was to compare the effects of morphine, pentobarbital, pentazocine and nalorphine on 1) the EEG activity, 2) the threshold for electrocortical recruitment, and 3) bioelectrical responses in the brain stem elicited by ...
R. N. Straw, C. L. Mitchell
semanticscholar   +1 more source

Pharmacological effects of nalorphine and nalorphine-7,8-oxide (nalorphine-epoxide): interaction of the intrinsic activity, affinity and pharmacological responses.

Archives internationales de pharmacodynamie et de therapie, 1986
We examined the relationship between the pharmacological effects and the interactions of the receptors of nalorphine and its epoxide. The abilities of nalorphine-epoxide to displace [3H]-dihydromorphine (mu-site) and [3H]-ethylketocyclazocine (kappa-site) were practically equal to those of the parent compound, nalorphine, using binding assay to the rat
F, Konno, C, Kobayashi, R, Morimoto, I, Takayanagi, N, Cho, M, Hirobe   +5 more
openaire   +1 more source