Nalorphine - Open Access .click

Results 11 to 20 of about 2,213 (148)

Advances in the Physicochemical Profiling of Opioid Compounds of Therapeutic Interest. [PDF]

ChemistryOpen, 2019
Who is in charge? In solutions, naloxone exists in four differently charged forms. Its overall lipophilicity profile indicated by the broad black line is the sum of the contributions of its four forms. Although the non‐charged form of naloxone is less lipophilic than naltrexone, its relative concentration at physiological pH is higher.
Mazák K, Noszál B, Hosztafi S.
europepmc +2 more sources

The Concise Guide to PHARMACOLOGY 2023/24: G protein-coupled receptors

British Journal of Pharmacology, Volume 180, Issue S2, Page S23-S144, October 2023., 2023
The Concise Guide to PHARMACOLOGY 2023/24 is the sixth in this series of biennial publications. The Concise Guide provides concise overviews, mostly in tabular format, of the key properties of approximately 1800 drug targets, and about 6000 interactions with about 3900 ligands.
Stephen P. H. Alexander +165 more
wiley +1 more source

Hair testing applied to the assessment of in utero exposure to drugs: Critical analysis of 51 cases of the University Hospital of Verona

Drug Testing and Analysis, Volume 15, Issue 9, Page 980-986, September 2023., 2023
Hair testing provides valuable and objective information on in utero drug exposure. To obtain a complete picture of the mother's addiction behaviour and of her family background, it is advisable to collect on the day of birth or the day after birth not only hair from the mother, newborn and father but also urine from the mother and newborn. Cocaine and
Anna Bertaso +8 more
wiley +1 more source

The Oxford Catalogue of Opioids: A systematic synthesis of opioid drug names and their pharmacology

British Journal of Clinical Pharmacology, Volume 87, Issue 10, Page 3790-3812, October 2021., 2021
Aim The growing demand for analgesia, coupled with an increasing need to treat opioid dependence and overdose, has escalated the development of novel opioids. We aimed to quantify the number of opioid drugs developed and to catalogue them based on their pharmacology.
Georgia C. Richards +3 more
wiley +1 more source

THE CONCISE GUIDE TO PHARMACOLOGY 2021/22: G protein‐coupled receptors

British Journal of Pharmacology, Volume 178, Issue S1, Page S27-S156, October 2021., 2021
The Concise Guide to PHARMACOLOGY 2021/22 is the fifth in this series of biennial publications. The Concise Guide provides concise overviews, mostly in tabular format, of the key properties of nearly 1900 human drug targets with an emphasis on selective pharmacology (where available), plus links to the open access knowledgebase source of drug targets ...
Stephen P H Alexander +154 more
wiley +1 more source

Activation profiles of opioid ligands in HEK cells expressing δ opioid receptors

BMC Neuroscience, 2002
Background The aim of the present study was to characterize the activation profiles of 15 opioid ligands in transfected human embryonic kidney cells expressing only δ opioid receptors.
Clark J +3 more
doaj +1 more source

Analysis of naltrexone and its metabolite 6-beta-naltrexol in serum with high-performance liquid chromatography

BMC Research Notes, 2012
Background Naltrexone has been proven to be an effective treatment option for the treatment of alcohol dependency. In this article we introduce a reliable and simple method developed for the simultaneous determination of naltrexone and 6-β-naltrexol in ...
Heinälä Pekka +5 more
doaj +1 more source

THE CONCISE GUIDE TO PHARMACOLOGY 2019/20: G protein‐coupled receptors

British Journal of Pharmacology, Volume 176, Issue S1, Page S21-S141, December 2019., 2019
The Concise Guide to PHARMACOLOGY 2019/20 is the fourth in this series of biennial publications. The Concise Guide provides concise overviews of the key properties of nearly 1800 human drug targets with an emphasis on selective pharmacology (where available), plus links to the open access knowledgebase source of drug targets and their ligands (www ...
Stephen P H Alexander +138 more
wiley +1 more source

Analgesic and Nonanalgesic Effects of Intravenous Hydromorphone ‐ Relation to Plasma Concentrations in Healthy Volunteers

Pain Research and Management, Volume 1, Issue 2, Page 86-92, 1996., 1996
OBJECTIVE: To investigate the analgesic and nonanalgesic effects and the pharmacokinetics of an intravenous infusion of 2 mg hydromorphone over 20 mins. DESIGN: Open study. SUBJECTS: Twelve healthy volunteers. MEASUREMENTS: The analgesic effect of hydromorphone was evaluated serially using pressure pain thresholds (PPTs) measured on the third fingers ...
D Westerling, H Bjork, P Svedman, P Hoglund +3 more
wiley +1 more source

Behavioural Effects and Naloxone Effectiveness With New Synthetic Opioids

Drug and Alcohol Review, EarlyView.
ABSTRACT Introduction The global drug market has seen an emergence of potent synthetic opioids, including benzimidazole‐derived substances known as nitazenes. These compounds have been implicated in fatal and non‐fatal overdoses. This review aims to synthesise current evidence on the pharmacological effects, potency and naloxone responsiveness of new ...
Suzanne Nielsen +8 more
wiley +1 more source

internal medicine
opioid
chemistry

anesthesia
pharmacology
morphine

psychology
biochemistry
endocrinology