Results 91 to 100 of about 76,320 (330)

Clinical and demographic characteristics of adolescents, emerging adults, and young adults presenting to an emergency department following a suicide attempt

JCPP Advances, EarlyView.
Abstract Introduction Suicide is a significant public health concern and the second leading cause of death in adolescents and young adults. This study sought to better understand differences in demographic and clinical characteristics of young people who attempted suicide during three phases of this developmental period: late adolescence (14–17 years),
Nicholas M. Brdar, Natasha K. Matta, Chloe A. Miner, Mubashshir R. Bhuiyan, Irmgard G. Pallas, Anna L. Bickersteth, Hailey G. Prokop, Lindsay A. Bornheimer   +7 more
wiley   +1 more source

In vitro and in vivo pharmacological activities of 14-o-phenylpropyloxymorphone, a potent mixed mu/delta/kappa-opioid receptor agonist with reduced constipation in mice [PDF]

, 2018
Pain, particularly chronic pain, is still an unsolved medical condition. Central goals in pain control are to provide analgesia of adequate efficacy and to reduce complications associated with the currently available drugs.
Lattanzi, Roberta, Negri, Lucia, Rief, Silvia, Schmidhammer, Helmut, Spetea, Mariana.   +4 more
core   +2 more sources

Safe Sound: Highlighting Electronic Dance Music Attendees' Unique Hearing Protection Practices

The Laryngoscope, EarlyView.
Electronic dance music attendees (EDMAs) stand out as a group more likely to use hearing protection (HP) compared to non‐EDM attendees (non‐EDMAs), making them an interesting focus for understanding the adoption of healthier auditory habits. This study delved into the factors driving HP use among EDMAs, uncovering key influences such as personal ...
Oluwatobiloba Ayo‐Ajibola, Tyler Jung, Matthew E. Lin, Ryan Long, John Parsons, Janet S. Choi, Joni Doherty   +6 more
wiley   +1 more source

7‑hydroxymitragynine is an active metabolite of mitragynine and a key mediator of its analgesic effects [PDF]

, 2019
Mitragynina speciosa, more commonly known as kratom, is a plant native to Southeast Asia, the leaves of which have been used traditionally as a stimulant, analgesic, and treatment for opioid addiction.
Ansonoff, Michael, Gassaway, Madalee M., Grinnell, Steven G., Javitch, Jonathan A., Kruegel, Andrew C., Langreck, Cory, Le Rouzic, Valerie, Majumdar, Susruta, Pasternak, Gavril W., Pekarskaya, Elizabeth A., Pintar, John E., Sames, Dalibor, Uprety, Rajendra   +12 more
core   +3 more sources

Readiness and recovery : switching between methadone and buprenorphine/naloxone for the treatment of opioid use disorder : a 90 credit thesis submitted in partial fulfillment of the requirements for the degree of Master of Nursing at Massey University, Wellington, New Zealand [PDF]

, 2016
Opioid substitution treatment is an effective form of treatment for opioid use disorders. Long acting opiates are used as part of treatment with methadone and buprenorphine/naloxone (BUP/NX) most frequently prescribed.
Bishop, Blair Thomas
core  

Buprenorphine added on brief cognitive behavioral therapy for treatment of methamphetamine use disorder [PDF]

, 2018
Background: Methamphetamine (MA) use remains a major public health concern around the world. Recent findings suggest that buprenorphine may be helpful for cocaine use reduction. Moreover, animal studies described reduced dopamine peak effect following MA
Dean AJ, Hassani-Abharian P, Hollister LE, Karimlou M, Kirchmayer U, Kosten TR, Mello NK, Nejati V, Raistrick D, Rothenberg JL,     +10 more
core   +1 more source

The use of low‐dose dexmedetomidine constant rate infusion to stabilise blood glucose in a domestic ferret (Mustela putorius furo) with insulinoma undergoing sevoflurane anaesthesia

Veterinary Record Case Reports, EarlyView.
Abstract A 5.5‐year‐old, male domestic ferret (Mustela putorius furo) diagnosed with insulinoma was presented for a dental procedure under general anaesthesia. In insulinoma patients, it is essential to avoid hypoglycaemia. In other species, constant rate infusion of dexmedetomidine has been reported to sustain adequate blood glucose by inhibiting ...
Anika R. Schiele, Patricia E. Kunze, Manuela L. Wieser, Annette P. N. Kutter   +3 more
wiley   +1 more source

The uptake of the pharmacy-dispensed naloxone kit program in Ontario: A population-based study.

PLoS ONE, 2019
BACKGROUND:Naloxone is a life-saving antidote for opioid overdoses. In June 2016, the Ontario government implemented the Ontario Naloxone Program for Pharmacies (ONPP) to enhance access to naloxone.
Beatrice Choremis, Tonya Campbell, Mina Tadrous, Diana Martins, Tony Antoniou, Tara Gomes   +5 more
doaj   +1 more source

Higher naloxone dosing in a quantitative systems pharmacology model that predicts naloxone-fentanyl competition at the opioid mu receptor level.

PLoS ONE, 2020
Rapid resuscitation of an opioid overdose with naloxone, an opioid antagonist, is critical. We developed an opioid receptor quantitative systems pharmacology (QSP) model for evaluation of naloxone dosing.
Ronald B Moss, Meghan McCabe Pryor, Rebecca Baillie, Katherine Kudrycki, Christina Friedrich, Mike Reed, Dennis J Carlo   +6 more
doaj   +1 more source

Racial and Ethnic Differences in the Effects of Prescription Drug Monitoring Program Laws on Overdose Deaths in the United States

The Milbank Quarterly, EarlyView.
Policy Points State “must‐query” prescription drug monitoring programs (PDMPs) were associated with increased overdose deaths, suggesting these policies may have unintended consequences. Black and Hispanic populations experienced disproportionately higher increases in overdose deaths following must‐query PDMP adoption, highlighting that these policies ...
SPRUHA JOSHI, VICTORIA A. JENT, SNEHA M. SUNDER, KATHERINE WHEELER‐MARTIN, MAGDALENA CERDÁ   +4 more
wiley   +1 more source