Results 81 to 90 of about 101,541 (346)
Glia, EarlyView.Cell culture studies show disrupted astrocyte physiology in the leukodystrophy MLC. Are intact astrocytes similarly affected? This study on astrocytes in MLC mouse brain slices confirms and extends in vitro studies on altered astrocyte physiology. ABSTRACT Electrical signaling, driven by ion fluxes between intra‐ and extracellular compartments, is ...
Sven Kerst +5 more
wiley +1 more source
Preventive Medicine Reports, 2019 The rate of opioid misuse and overdose continues to increase in rural areas of the U.S. In response, access to naloxone hydrochloride (“naloxone”), an opioid antagonist used to reverse opioid overdose, has increased among both first responders and ...
Tess M. Kilwein +3 more
doaj
The influence of μ-opioid and noradrenaline reuptake inhibition in the modulation of pain responsive neurones in the central amygdala by tapentadol in rats with neuropathy [PDF]
, 2015 Treatments for neuropathic pain are either not fully effective or have problematic side effects. Combinations of drugs are often used. Tapentadol is a newer molecule that produces analgesia in various pain models through two inhibitory mechanisms, namely
Dickenson, AH, Friend, LV, Gonçalves, L
core
Spatial Concentration of Opioid Overdose Deaths in Indianapolis: An Application of the Law of Crime Concentration at Place to a Public Health Epidemic [PDF]
, 2019 The law of crime concentration at place has become a criminological axiom and the foundation for one of the strongest evidence-based policing strategies to date.
Carter, Jeremy G. +2 more
core +1 more source
The Moral Hazard of Lifesaving Innovations: Naloxone Access, Opioid Abuse, and Crime
Social Science Research Network, 2018 The United States is experiencing an epidemic of opioid abuse. In response, many states have increased access to naloxone, a drug that can save lives when administered during an overdose. However, naloxone access may unintentionally increase opioid abuse
Jennifer L. Doleac, Anit Mukherjee
semanticscholar +1 more source
Addiction stigma and the production of impediments to take-home naloxone uptake
Health, 2020 Opioid overdose deaths are a major health issue in Australia and around the world. Programmes to provide opioid consumers with ‘take-home’ naloxone to reverse overdose exist internationally, but uptake by mainstream health services and consumers remains ...
Renae Fomiatti +5 more
semanticscholar +1 more source
Pediatric Blood &Cancer, EarlyView.ABSTRACT Background Patients with sickle cell disease (SCD) experience painful vaso‐occlusive episodes that increase with age; a subset develops chronic pain (CP). CP is usually managed with acute pain management guidelines despite evidence of ineffectiveness.
Ashwin Patel +6 more
wiley +1 more source
Effects of pharmacist-driven protocol on naloxone prescribing rates in two primary care clinics
Preventive Medicine Reports, 2023 The Centers for Disease Control and Prevention (CDC) Guidelines for Prescribing Opioids for Chronic Pain recommend co-prescribing naloxone as a harm reduction strategy when there is an increased risk of opioid overdose.
Ashley Daffron +3 more
doaj
Intention to get naloxone among patients prescribed opioids for chronic pain
Harm Reduction Journal, 2022 Background Prescription opioids have been increasingly prescribed for chronic pain while the opioid-related death rates grow. Naloxone, an opioid antagonist, is increasingly recommended in these patients, yet there is limited research that investigates ...
Yinan Huang +5 more
doaj +1 more source
JAMA Network Open, 2020 Key Points Question Is prior authorization associated with reduced use of buprenorphine-naloxone and increased emergency department visits and hospitalizations?
T. Mark, William J. Parish, G. Zarkin
semanticscholar +1 more source