Results 71 to 80 of about 18,139 (185)

Do opioid receptors play a role in the pathogenesis of the inflammatory response in acute pancreatitis? Os receptores opioides desempenham papel na patogênese da resposta inflamatória na pancreatite aguda?

Acta Cirúrgica Brasileira, 2012
PURPOSE: To investigate the effect of the opioid blocker naltrexone in the inflammatory response in acute pancreatitis (AP). METHODS: Acute pancreatitis was induced in anesthetized male Wistar rats by retrograde injection of 2.5% sodium taurocholate ...
Artur Penido, Ana Maria Mendonça Coelho, Nilza Trindade Molan, Fabiano Pinheiro da Silva, Luiz Augusto Carneiro D'Albuquerque, Marcel Cerqueira Cesar Machado   +5 more
doaj   +1 more source

Alcohol use disorder: an Australian perspective on screening, diagnosis, treatment and prevention

Internal Medicine Journal, EarlyView.
Abstract Alcohol is one of Australia's most harmful recreational drugs, contributing more to death, disease and economic harm than all illicit drugs combined. Though it accounts for 4.1% of the national disease burden, it remains under‐prioritised in health policy, prevention and treatment.
Andrew J. Palmer, Jason P. Connor, Paul J. Clark   +2 more
wiley   +1 more source

Medical Knowledge Integration Into Reinforcement Learning Algorithms for Dynamic Treatment Regimes

International Statistical Review, EarlyView.
Summary The goal of precision medicine is to provide individualised treatment at each stage of chronic diseases, a concept formalised by dynamic treatment regimes (DTR). These regimes adapt treatment strategies based on decision rules learned from clinical data to enhance therapeutic effectiveness.
Sophia Yazzourh, Nicolas Savy, Philippe Saint‐Pierre, Michael R. Kosorok   +3 more
wiley   +1 more source

A comparative study evaluating the efficacy of naltrexone versus acamprosate as anticraving agents in alcohol use disorder

Industrial Psychiatry Journal
Background: Alcohol use disorders (AUDs) are characterized by excessive alcohol consumption, negatively impacting health, social life, and economic status. Globally, AUD contributes to significant disease burden, causing millions deaths annually. Despite
Samant Singh, Lakhan Kataria, Mohd Rashid Alam   +2 more
doaj   +1 more source

Prevalence and Factors Associated With Symptom Profiles of Disorders of Gut‐Brain Interaction in Obesity Before and After Treatment

Neurogastroenterology &Motility, EarlyView.
DGBI symptoms are common in obesity and have the potential to exacerbate negative health outcomes. In general, the prevalence of DGBI symptoms decreases after obesity treatment, but patients can also shift from one GI symptom profile to another. ABSTRACT Background & Aims Disorders of gut‐brain interaction (DGBI) in obesity could impair health outcomes.
Esther Colomier, Janita Halminen, Malin Björck, Gudrún Höskuldsdóttir, Karin Mossberg, My Engström, Björn Eliasson, Ville Wallenius, Lars Fändriks, Jan Tack, Hans Törnblom, Magnus Simrén   +11 more
wiley   +1 more source

Serious adverse events reported in placebo randomised controlled trials of oral naltrexone: a systematic review and meta-analysis

BMC Medicine, 2019
Background Naltrexone is an opioid antagonist used in many different conditions, both licensed and unlicensed. It is used at widely varying doses from 3 to 250 mg.
Monica Bolton, Alex Hodkinson, Shivani Boda, Alan Mould, Maria Panagioti, Sarah Rhodes, Lisa Riste, Harm van Marwijk   +7 more
doaj   +1 more source

Understanding Impact of Anti‐Obesity Medications on Skeletal Muscle Mass Change Is Confounded by Measurement Methods

Obesity Reviews, EarlyView.
ABSTRACT Anti‐obesity medications promote greater degrees of weight loss than lifestyle interventions alone. There is an important need to understand whether loss of skeletal muscle during pharmacologically induced weight loss is clinically significant due to its essential role in health and disease.
Arden McMath, Dympna Gallagher
wiley   +1 more source

Multidisciplinary Therapy to Target Obesity and Its Complications in Adult Population: A Narrative Review

Obesity Reviews, EarlyView.
ABSTRACT Obesity as a chronic and multifactorial disease requires a multidisciplinary team acting together in a holistic multitarget intervention. Multidisciplinary therapy targeting obesity and its complications includes physical exercise, nutritional, and behavior counseling.
Ana Raimunda Dâmaso, Flávia Campos Corgosinho, Deborah Cristina Landi Masquio, Nayra Figueiredo, Fabiana Kattah, Cintia Cercato, Lian Tock, Raquel Munhoz da Silveira Campos   +7 more
wiley   +1 more source

Efficacy of Weight‐Lowering Agents on Fat Distribution: A Systematic Review and Network Meta‐Analysis of Randomized Controlled Trials

Obesity Reviews, EarlyView.
ABSTRACT Background Pharmacotherapy offers a potential solution for individuals with overweight and obesity to decrease their body weight. However, there is limited knowledge of the effects of antiobesity agents on the distribution of body fat. Methods The PubMed, Embase, and Cochrane Library databases were reviewed for randomized controlled trials ...
Xiuqi Qiao, Weihao Wang, Jiaming Cao, Lixin Guo, Qi Pan   +4 more
wiley   +1 more source

Surgical management of an open humeral fracture in a greater rhea (Rhea americana): Internal placement of a locking compression plate and post‐operative complications

Veterinary Record Case Reports, Volume 14, Issue 2, May 2026.
SUMMARY A 17‐year‐old, 24‐kg, female greater rhea (Rhea americana) presented with an acute onset of left wing droop. Clinical examination and radiographs revealed an open, simple, displaced, short‐oblique diaphyseal fracture of the distal third of the left humerus.
Pierre Huberdeau, Thomas Coutant, Aram Arslanian, Emeline Maurice, Fouad Stephan, Sylvie Laidebeure, Alexis Lécu   +6 more
wiley   +1 more source