Results 1 to 10 of about 4,900 (222)

Effects of concurrent intravenous morphine sulfate and naltrexone hydrochloride on end-tidal carbon dioxide [PDF]

Harm Reduction Journal, 2012
Background Respiratory depression, a potentially fatal side-effect of opioid-overdose, may be reversed by timely administration of an opioid antagonist, such as naloxone or naltrexone.
Goli Veeraindar, Webster Lynn R, Lamson Michael J, Cleveland Jody M, Sommerville Kenneth W, Carter Eric   +5 more
doaj   +6 more sources

Probing the Release of Bupropion and Naltrexone Hydrochloride Salts from Biopolymeric Matrices of Diverse Chemical Structures [PDF]

Polymers, 2021
In the last decades, the notion of including excipients in the formulations, as inert substances aiding production processes, has changed and they are recently viewed as multifunctional discrete entities. It is now well documented that excipients serve several roles, spreading from the stabilization and modified release, to providing biocompatible ...
Angeliki Siamidi, Aikaterini Dedeloudi, Marilena Vlachou   +2 more
europepmc   +6 more sources

Microbiological Estimation of Nasal Spray Containing Naltrexone Hydrochloride

Разработка и регистрация лекарственных средств, 2020
Introduction. In order to standardize the quality indicators during the expected shelf life of the developed drug naltrexone hydrochloride in the form of a nasal spray containing a high concentration of poloxamer and benzalkonium chloride as a ...
Yu. M. Domnina, V. V. Suslov, N. E. Grammatikova, S. A. Kedik   +3 more
doaj   +4 more sources

Study of Acute Toxicity and Irritant Effect of Nasal Spray Naltrexone Hydrochloride

Разработка и регистрация лекарственных средств, 2021
Introduction. Acute toxicity of naltrexone hydrochloride nasal spray during intragastric administration to mice and local irritant effect on rabbits was studied.
Yu. M. Domnina, V. V. Suslov, S. A. Kedik, D. A. Akhmedova, A. P. Malkova   +4 more
doaj   +4 more sources

Compatibility of caffeine, carvedilol, clomipramine hydrochloride, folic acid, hydrochlorothiazide, loperamide hydrochloride, methotrexate, nadolol, naltrexone hydrochloride and pentoxifylline in SyrSpend SF PH4 oral suspensions [PDF]

European Journal of Hospital Pharmacy, 2016
The objective of this study was to evaluate the compatibility of 10 commonly used active pharmaceutical ingredients (APIs) compounded in oral suspensions using a globally available suspending vehicle (SyrSpend SF PH4 liquid): caffeine 10.0 mg/mL, carvedilol 1.0 mg/mL, clomipramine hydrochloride 5.0 mg/mL, folic acid 1.0 mg/mL, hydrochlorothiazide 5.0 ...
Hudson C, Polonini, Sharlene L, Silva, Thalyta R, de Almeida, Marcos Antônio F, Brandão, Anderson O, Ferreira   +4 more
europepmc   +5 more sources

Quantitative Determination of Benzalconium Chloride in the Naltrexone Hydrochloride Nasal Spray

Разработка и регистрация лекарственных средств, 2020
Introduction. Benzalkonium chloride is widely used as a conservation agent in medicines. For quantitative determination, the methods described in the European and American Pharmacopoeias by chromatography using columns with nitrile sorbent are often used.
Yu. M. Domnina, V. V. Suslov, S. A. Kedik, E. V. Vorfolomeeva, A. V. Meleshko   +4 more
doaj   +4 more sources

Quantitative Determination of Naltrexone Hydrochloride in a Nasal Spray by High-performance Liquid Chromatography

Разработка и регистрация лекарственных средств, 2020
Introduction. Naltrexone, an antagonist of µ-opioid receptors, is promising for the treatment of various autoimmune and oncological diseases when used in doses of 1.5–5 mg/day. To date, there are no medications that provide such dosages of naltrexone.Aim.
Yu. M. Domnina, V. V. Suslov, S. A. Kedik, E. V. Vorfolomeeva, A. V. Meleshko   +4 more
doaj   +4 more sources

Morphine sulfate and naltrexone hydrochloride extended-release capsules: naltrexone release, pharmacodynamics, and tolerability. [PDF]

Pain physician, 2011
Morphine sulfate and naltrexone hydrochloride extended-release capsules (EMBEDA, King Pharmaceuticals, Inc., Bristol, TN), indicated for management of chronic, moderate-to-severe pain, contain pellets of extended-release morphine sulfate with a sequestered naltrexone core (MS-sNT). Taken as directed, morphine provides analgesia while naltrexone remains
Franklin, Johnson, Beatrice, Setnik
  +9 more sources

RATIONALE FOR THE SELECTION OF AUXILIARY COMPONENTS FOR THE NALTREXONE HYDROCHLORIDE NASAL SPRAY

Разработка и регистрация лекарственных средств, 2019
The work is devoted to the development of nasal spray containing naltrexone hydrochloride. Naltrexone in doses of 3-5 mg/day acts on the opioid growth factor receptor (OGFr) and toll-like receptor 4 that makes it promising for use in the complex therapy ...
Y. M. Domnina, S. A. Kedik, V. V. Suslov, E. A. Shnyak   +3 more
doaj   +2 more sources

New Construction of Functionalized CuO/Al₂O₃ Nanocomposite-Based Polymeric Sensor for Potentiometric Estimation of Naltrexone Hydrochloride in Commercial Formulations. [PDF]

Polymers (Basel), 2021
Al-Mohaimeed AM, Mostafa GAE, El-Tohamy MF.   +2 more
europepmc   +3 more sources