Results 61 to 70 of about 4,819 (199)
Multi‐scale maternal behavioral responses by white‐tailed deer to coyote predation risk
The Journal of Wildlife Management, Volume 90, Issue 1, January 2026.In the piedmont region of the southeastern US, white‐tailed deer adjust maternal care strategies in response to variation in risk of encountering coyotes. In areas frequented by coyotes, adult female deer (i.e., does) increase their use of space, likely to avoid drawing coyotes to the location where a fawn is hidden.Michael S. Muthersbaugh, Wesley W. Boone, Elizabeth A. Saldo, Alex J. Jensen, Charles Ruth, Jay Cantrell, John C. Kilgo, David S. Jachowski +7 morewiley +1 more sourceA Population Pharmacokinetic Model to Assess the Cytochrome P450 2B6 Metabolic Probe Bupropion and Hydroxybupropion in Vitamin D‐Insufficient and ‐Replete Patients With Kidney Disease
Journal of Clinical Pharmacy and Therapeutics, Volume 2026, Issue 1, 2026.Objective
The aim of this study was to use bupropion as a cytochrome P450 (CYP) 2B6 probe to determine CYP2B6 function by using a population pharmacokinetic approach of parent bupropion and metabolite hydroxybupropion to explore the impacts of chronic kidney disease (CKD) and vitamin D status in patients and control subjects.Avisek Ghimire, Stacey M. Tuey, Linda Prebehalla, Amandla Atilano-Roque, Gavriel Roda, Lauren E. Thompson, Michel B. Chonchol, Nirav Shah, Michael F. Wempe, Thomas D. Nolin, Melanie S. Joy, Irina B. Bondareva +11 morewiley +1 more sourceCombining Varenicline (Chantix) with Naltrexone Decreases Alcohol Drinking More Effectively Than Does Either Drug Alone in a Rodent Model of Alcoholism [PDF]
, 2016 Background
This study examined whether varenicline (VAR), or naltrexone (NTX), alone or in combination, reduces alcohol drinking in alcohol-preferring (P) rats with a genetic predisposition toward high voluntary alcohol intake.Dilley, Julian E., Filosa, Nick, Fischer, Stephen M., Froehlich, Janice C., Nicholson, Emily, Rademacher, Logan, Smith, Teal +6 morecore +4 more sourcesThe Concise Guide to PHARMACOLOGY 2025/26: G protein‐coupled receptors
British Journal of Pharmacology, Volume 182, Issue S1, Page S24-S151, December 2025.The Concise Guide to Pharmacology 2025/26 marks the seventh edition in this series of biennial publications in the British Journal of Pharmacology. Presented in landscape format, the guide provides a comparative overview of the pharmacology of drug target families. The concise nature of the Concise Guide refers to the style of presentation, being clear,Stephen P. H. Alexander, Anthony P. Davenport, Eamonn Kelly, Alasdair J. Gibb, Alistair A. Mathie, Chloe J. Peach, Emma L. Veale, Jane F. Armstrong, Elena Faccenda, Simon D. Harding, Christopher Southan, Jamie A. Davies, Maria Pia Abbracchio, George R. Abraham, Alexander Agoulnik, Wayne Alexander, Khaled Al‐hosaini, Magnus Bäck, Jillian G. Baker, Nicholas M. Barnes, Ross Bathgate, Jean‐Martin Beaulieu, Annette G. Beck‐Sickinger, Maik Behrens, Kirstie A. Bennett, Kenneth E. Bernstein, Bernhard Bettler, Nigel J. M. Birdsall, Victoria A. Blaho, Pascal Bonaventure, Francois Boulay, Corinne Bousquet, Hans Bräuner‐Osborne, Andrew J. Brown, Geoffrey Burnstock, Marta Busnelli, Girolamo Caló, Vanni Caruso, Justo P. Castaño, Kevin J. Catt, Stefania Ceruti, Paul Chazot, Nan Chiang, Bice Chini, Arthur Christopoulos, Jerold Chun, Antonia Cianciulli, Olivier Civelli, Lucie H. Clapp, Réjean Couture, Helen M. Cox, Zsolt Csaba, Claes Dahlgren, Frank M. Dautzenberg, Gordon Dent, Steven D. Douglas, Pascal Dournaud, Margarita L. Dubocovich, Satoru Eguchi, Emanuel Escher, Edward J. Filardo, Tung Fong, Huamei Fu Forsman, Marta Fumagalli, Raul R. Gainetdinov, Michael L. Garelja, Marc de Gasparo, Florence Gbahou, Craig Gerard, Marvin Gershengorn, Michelle Glass, David E. Gloriam, Fernand Gobeil, Theodore L. Goodfriend, Cyril Goudet, Lukas Grätz, Karen J. Gregory, Christian Gruber, Andrew L. Gundlach, Jörg Hamann, Julien Hanson, Deborah S. Hartman, Richard L. Hauger, Debbie L. Hay, Akos Heinemann, Laura Heitman, Deron R. Herr, Morley D. Hollenberg, Nicholas D. Holliday, Birgitte Holst, Mastgugu Horiuchi, Daniel Hoyer, László Hunyady, Ahsan Husain, Adriaan P. IJzerman, Tadashi Inagami, Paul A. Insel, Kenneth A. Jacobson, Laura H. Jacobson, Robert T. Jensen, Ralf Jockers, Deepa Jonnalagadda, Sadashiva Karnik, Klemens Kaupmann, Jacqueline Kemp, Charles Kennedy, Yasuyuki Kihara, Julia Kinsolving, Takio Kitazawa, Pawel Kozielewicz, Hans‐Jürgen Kreienkamp, Jyrki P. Kukkonen, Luxmichan Laishram, Tobias Langenhan, Christopher J. Langmead, Dan Larhammar, Katie Leach, Davide Lecca, John D. Lee, Susan E. Leeman, Jérôme Leprince, Rob Leurs, Xaria X. Li, Ines Liebscher, Stephen J. Lolait, Amelie Lupp, Robyn Macrae, Janet J. Maguire, Davide Malfacini, Maurice Manning, Davide Marangon, Kirill Martemyanov, Jean Mazella, Craig A. McArdle, Shlomo Melmed, Martin C. Michel, Laurence J. Miller, Vincenzo Mitolo, Bernard Mouillac, Christa E. Müller, Philip M. Murphy, Jean‐Louis Nahon, Richard R. Neubig, Tony Ngo, Xavier Norel, Duuamene Nyimanu, Anne‐Marie O’Carroll, Stefan Offermanns, Maria Antonietta Panaro, Marc Parmentier, Nicole Perry‐Hauser, Roger G. Pertwee, Jean‐Philippe Pin, Eric R. Prossnitz, Helena Chengxue Qin, Mark Quinn, Stefano Raffaele, Rithwik Ramachandran, Manisha Ray, Rainer K. Reinscheid, Alejandro Romeral Buzón, Philippe Rondard, Mette M. Rosenkilde, G. Enrico Rovati, Chiara Ruzza, Gareth J. Sanger, Nicole Scholz, Torsten Schöneberg, Gunnar Schulte, Stefan Schulz, Deborah L. Segaloff, Charles N. Serhan, Arun K. Shukla, Khuraijam Dhanachandra Singh, Craig M. Smith, Nicola J. Smith, Claudia Stäubert, Leigh A. Stoddart, Yukihiko Sugimoto, Roger Summers, Valerie P. Tan, David M. Thal, Walter ( Wally) Thomas, Pieter B. M. W. M. Timmermans, Kalyan Tirupula, Lawrence Toll, Giovanni Tulipano, Hamiyet Unal, Thomas Unger, Celine Valant, Patrick Vanderheyden, David Vaudry, Hubert Vaudry, Joseph G. Verbalis, Jean‐Pierre Vilardaga, Christopher S. Walker, Ji Ming Wang, Donald T. Ward, Hans‐Jürgen Wester, Gary B. Willars, Tom Lloyd Williams, Trent M. Woodruff, Huixian Wu, Cheng Yang, Chengcan Yao, Richard D. Ye, Nathan Zaidman +206 morewiley +1 more sourceManagement of xylazine toxicity, overdose, dependence, and withdrawal: A systematic review
The American Journal on Addictions, Volume 34, Issue 6, Page 589-602, November 2025.Abstract Background and Objectives
Xylazine, an alpha‐2‐adrenergic agonist, has been increasingly implicated in substance use and overdose crises. However, little is known about its effects on humans. With the growing public health crisis surrounding xylazine, it has become important to recognize and promptly manage symptoms of xylazine toxicity ...Philipa Owusu‐Antwi, Priya Atodaria, Edmund Appiah‐Kubi, Zainab Shah, Elpidio Marlon Garcia +4 morewiley +1 more sourceNaltrexone Restores Impaired Transient Receptor Potential Melastatin 3 Ion Channel Function in Natural Killer Cells From Myalgic Encephalomyelitis/Chronic Fatigue Syndrome Patients
Frontiers in Immunology, 2019 Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) is a seriously long-term and debilitating illness of unknown cause hallmarked by chronic pain and fatigue, memory and concentration impairment, and inflammation.Helene Cabanas, Helene Cabanas, Helene Cabanas, Katsuhiko Muraki, Katsuhiko Muraki, Donald Staines, Donald Staines, Donald Staines, Sonya Marshall-Gradisnik, Sonya Marshall-Gradisnik, Sonya Marshall-Gradisnik +10 moredoaj +1 more sourceSerious adverse events reported in placebo randomised controlled trials of oral naltrexone: a systematic review and meta-analysis [PDF]
, 2019 Background
Naltrexone is an opioid antagonist used in many different conditions, both licensed and unlicensed. It is used at widely varying doses from 3 - 250 mg. The aim of this review was to evaluate the safety of oral naltrexone by examining the risk A Hodkinson, A Roy, A Thompson, AK Traore, Alan Mould, Alex Hodkinson, B Afsharimani, BAC Cree, C Brewer, Center for Drug Evaluation and Research, Center for Biologics Evaluation and Research. Guidance for industry and investigators, D Dalton, D Moher, D Walters, DA Zarin, DE Jonas, DK Patten, DN Pfohl, European Commission, European Commission, European Commission, G Raknes, G Raknes, GA Diamond, GBD 2015 Disease and Injury Incidence and Prevalence Collaborators, GBD 2015 Mortality and Causes of Death Collaborators, Harm van Marwijk, ICH Harmonised Tripartite Guideline, Immune Therapeutics Inc. Immune Therapeutics, Inc, IS Zagon, J Budzyński, J Rehm, J Younger, JE Becker, JE Grant, JE Grant, JG Bramness, JJ Kirkham, JMA Sinclair, JP Ioannidis, JP Smith, JPA Ioannidis, K Kampman, K McPherson, K Papay, K Witkiewitz, KM Sturn, L Zorzela, LB Weinstock, Lisa Riste, LJ Dunlap, M McDonough, Maria Panagioti, MH Yen, MJ Page, MJ Sweeting, Monica Bolton, N Jayaram-Lindström, P Crowley, PA Spagnolo, PM Rothwell, PN Papanikolaou, R Pryce, RA Johnson, RS Croop, S Cao, S Derry, S Rösner, S-E Brown, Sarah Rhodes, Shivani Boda, SS O’Malley, YK Loke, YK Loke, Z Yi +73 morecore +4 more sourcesMolecular Mechanisms of Chronic Pain and Therapeutic Interventions
MedComm, Volume 6, Issue 8, August 2025.We offer a comprehensive overview of the distinctive molecular mechanisms underlying nociceptive, neuropathic, and nociplastic pain, including the immune responses, ion channels, monoaminergic imbalance, and neuroinflammation. Subsequently, we summarized the status quo of nociceptive, neuropathic, and nociplastic pain managementmanipulation.Zhen Li, Xing Li, Jieqiong Liu, Rao Sun, Yingze Ye, Hongbing Xiang, Fang Luo, Shiyong Li, Ailin Luo +8 morewiley +1 more sourceEfficacy of naloxone in reducing hypoxemia and duration of immobility following focal to bilateral tonic–clonic seizures
Epilepsia Open, Volume 10, Issue 3, Page 880-893, June 2025.Abstract Objective
Evaluating the efficacy of an opioid antagonist, naloxone (NLX), to reduce the severity of post‐ictal hypoxemia and immobility after focal to bilateral tonic–clonic seizures (FBTCS). Methods
ENALEPSY is a double‐blind placebo (PCB)‐controlled trial conducted in patients with focal epilepsy undergoing long‐term video‐EEG monitoring ...Sylvain Rheims, Fatima Chorfa, Véronique Michel, Edouard Hirsch, Louis Maillard, Luc Valton, Fabrice Bartolomei, Philippe Derambure, Vincent Navarro, Julien Biberon, Arielle Crespel, Anca Nica, Martine Lemesle Martin, Laure Mazzola, Jerome Petit, Vincent Rossero, Sébastien Boulogne, Mathilde Leclercq, Laurent Bezin, Catherine Mercier, Pascal Roy, Philippe Ryvlin, on behalf of the ENALEPSY Study Group, V. Michel, M. De Montaudouin, M. Lemesle Martin, P. Kahane, L. Minotti, L. Vercueil, A. S. Jobst, J. Petit, D. Tourniaire, V. Eid, P. Latour, P. Derambure, W. Szurhaj, S. Rheims, H. Catenoix, N. Andre‐Obadia, J. Isnard, A. Montavont, S. Boulogne, F. Bartolomei, A. Trébuchon, A. Mc Gonigal, S. Aubert, S. Lagarde, A. Crespel, P. Gelisse, B. Mercedes, L. Maillard, L. Tyvaert, J. P. Vignal, V. Navarro, S. Dupont, C. Adam, V. Frazzini, V.‐H. Nguyen‐Michel, M. Damiano, V. Lambrecq, A. Biraben, A. Nica, P. Convers, L. Mazzola, E. Hirsch, M. P. Valenti, J. Scholly, C. Behr, L. Valton, M. Denuelle, J. Curot, J. Biberon +71 morewiley +1 more source
