Results 71 to 80 of about 4,819 (199)

Pharmacological treatment of obesity: an overview of different groups of anti-obesity drugs available in Poland

Journal of Education, Health and Sport
Introduction and Objective: Obesity, as one of the diseases of civilization, has become a significant problem in our time. Although the first ways of treating it appeared many years ago, pharmacotherapy of obesity has been developing significantly in ...
Barbara Woch, Dawid Bereza, Katarzyna Sokołowska, Maria Kulak, Igor Moreau, Paulina Polańska, Miriam Lang   +6 more
doaj   +1 more source

Poloxamer-based thermoresponsive ketorolac tromethamine in situ gel preparations : design, characterisation, toxicity and transcorneal permeation studies [PDF]

, 2017
This study was aimed at preparing, characterising and evaluating in situ gel formulations based on a blend of two hydrophilic polymers i.e. poloxamer 407 (P407) and poloxamer 188 (P188) for a sustained ocular delivery of ketorolac tromethamine (KT). Drug-
Abdelkader, Abdelkader, Abdelkader, Abdelkader, Abdelkader, Abdelkader, Abdelkader, Abdelkader, Abou El-elaa, Ajit, Al Khateb, Alany, Almeida, Amal K. Hussein, Angius, Anil Vangala, Asasutjarit, Attama, Auerbach, Baeyens, Baklayan, Baloglu, Chena, Dohle, Dumortier, El-Kamel, Faber, Fathalla, Fernández-Ferreiro, Garg, Gupta, Hao, Heilmann, Kadam, Khaled A. Khaled, Kim, Kim, Law, Li, Ling, Luepke, Mansour, Mayol, Michael Longman, Mosmann, Mythri, Nanjawade, Nanjwadea, Newa, Omar H. El-Garhy, Qi, Raid G. Alany, Riccia, Rooks, Rossi, Rupenthal, Rupenthala, Schoenwald, Sinha, Sintzel, Sunil, Thakor, Thrimawithana, Thrimawithanaa, Vadnere, Verstraelen, Walters, Wei, Weterings, Worakul, Xu, Yang, Zeinab M.A. Fathalla   +72 more
core   +1 more source

Longitudinal and Concurrent Changes in Brain and Gut due to Morphine Self‐Administration

Addiction Biology, Volume 30, Issue 6, June 2025.
With this work, we present evidence of longitudinal changes in the brain and gut microbiome following morphine use. We used a within‐subjects design to show that chronic administration of morphine alters 1) the striatum microstructure using MRI, 2) gut microbiome diversity derived from fecal samples, and 3) these changes are correlated to each other ...
Kaylee Brunetti, Zicong Zhou, Samia Shuchi, Raymond Berry, Sabrina White, Yan Zhang, Michael S. Allen, Shaohua Yang, Johnny D. Figueroa, Luis Colon‐Perez   +9 more
wiley   +1 more source

Molecular docking, molecular dynamics simulation, preparation, and characterization of naltrexone-phospholipid complex: A novel cargo with improved loading into multivesicular liposomes

Results in Chemistry
Naltrexone hydrochloride (NTX), a water-soluble opioid receptor antagonist, is prescribed widely for opioid and alcohol dependence and pain reduction. However, the significant limitations of NTX are low lipophilicity and extensive first-pass metabolism ...
Reihaneh Yousefi, Yasaman Rezaee, Fereshteh Bayat, Elham Rezaee, Leila Karami, Simin Dadashzadeh, Azadeh Haeri   +6 more
doaj   +1 more source

Recent Trends in the Development of Green Analytical Sample Preparation Methods Using Advanced Materials

Journal of Separation Science, Volume 48, Issue 5, May 2025.
ABSTRACT Recent concern about the impact of environmental preservation and the health of living beings has opened new avenues for scientific research. In this context, contemporary analytical chemistry has been marked by the development of green analytical methodologies, which aim to reduce the use of toxic reagents and minimize the environmental ...
Eduardo Carasek, Amanda Vitória Santos, Francielle Crocetta Turazzi, Lucas Morés, Luciane Effting, Guilherme Mariz de Oliveira Barra   +5 more
wiley   +1 more source

Over the counter naloxone nasal spray: A new hope for opioid crisis management in Pakistan

Journal of the Pakistan Medical Association
Opioids, derived from the poppy plant, include synthetic and partially synthetic compounds that bind to brain receptors, diminishing pain perception. Primarily prescribed as analgesics, they are often misused for euphoria, thus making opioid overdose a ...
Zmarak Ahmed Khan, Zainab Anfaal, Muhammad Shaheer   +2 more
doaj   +1 more source

The Potential Use of Cannabidiol in the Treatment of Opioid Use Disorder: A Systematic Review

Addiction Biology, Volume 30, Issue 5, May 2025.
This systematic review found that CBD may reduce opioid cravings and abstinence‐related anxiety in individuals with opioid use disorder. Preclinical studies also suggest CBD can reduce withdrawal symptoms, opioid‐rewarding effects, relapse, and neuroinflammation.
Mahan Shafie, Kevin Ing, Yasna Rostam‐Abadi, Jeremy Weleff, Mackenzie Griffin, Mohini Ranganathan, Ardavan Mohammad Aghaei, Nicholas Pratt, Melissa C. Funaro, Anahita Bassir Nia   +9 more
wiley   +1 more source

Furanylfentanyl. ANNEX 1. Technical report on N-phenyl-N- [1-(2-phenylethyl)piperidin-4-yl]furan- 2-carboxamide (furanylfentanyl). [PDF]

, 2018
This publication presents the data and findings of the risk assessment on furanylfentanyl (N-phenyl-N-[1-(2-phenylethyl)piperidin-4-yl]furan-2-carboxamide), carried out by the extended Scientific Committee of the EMCDDA on 23 May 2017.
Almeida, A, Brandt, SD, Christie, R, Elliott, S, Evans-Brown, M, Gallegos, A, Jorge, R, Sedefov, R, Valur Danielsson, H   +8 more
core   +1 more source

An eco-friendly smartphone based HPTLC method versus conventional densitometric one for determination of Naltrexone and Bupropion

BMC Chemistry
The rapid uprising technologies of smartphone applications and software introduced a new era for analytical detection techniques. It has transformed bench-top laboratory methods into simpler ones depending on cost-effective, portable, and widely ...
Eman M. Moaaz, Ezzat M. Abdel-Moety, Mamdouh R. Rezk, Ahmed S. Fayed   +3 more
doaj   +1 more source

Dissolution Assay of Bupropion/Naltrexone Hydrochloride Salts of Bilayer Composition Tablets Following the Development and Validation of a Novel HPLC Method. [PDF]

Materials (Basel), 2022
Apostolidi A, Protopapa C, Siamidi A, Vlachou M, Dotsikas Y.   +4 more
europepmc   +1 more source