Results 31 to 40 of about 15,050 (215)
Radial shape discrimination testing for new-onset neovascular age-related macular degeneration in at-risk eyes. [PDF]
PLoS ONE, 2018 We investigated the performance of the handheld radial shape discrimination (hRSD) test in detecting the development of neovascular AMD (nAMD) in a prospective, longitudinal, observational study.
Noelia Pitrelli Vazquez +4 more
doaj +1 more source
Journal of Chemical Theory and Computation, 2015 Proper treatment of nonbonded interactions is essential for the accuracy of molecular dynamics (MD) simulations, especially in studies of lipid bilayers.
Jumin Lee +16 more
semanticscholar +1 more source
BMC Health Services Research, 2022 Background Age-related macular degeneration (AMD) is a common and chronic eye condition characterized by the presence of progressive degenerative abnormalities in the central retina (macula).
Nicola Ferrante +3 more
semanticscholar +1 more source
Frontiers in Endocrinology, 2022 Lipid dyshomeostasis has been implicated in the pathogenesis of various retinal and choroidal vascular diseases. This study aims to investigate whether apolipoprotein (apo) mediated differential regulation of lipid metabolism contributes to the ...
Xinyuan Zhang +9 more
doaj +1 more source
MSC-Derived Exosomal lnc-AGT-3: A Novel Anti-Angiogenic Target in Age-Related Macular Degeneration Through p53 Signaling Pathway. [PDF]
Aging CellMSC‐derived exosomes deliver lnc‐AGT‐3 to vascular endothelial cells, where it binds hnRNP K in the nucleus. This interaction inhibits p53 ubiquitination, enhancing p53 stabilization and transcriptional activation of anti‐angiogenic targets TSP1. Consequently, p53‐mediated signaling is potentiated, effectively suppressing choroidal neovascularization ...
Kong L +9 more
europepmc +2 more sources
BMJ Open Ophthalmology, 2022 Objective To evaluate correlations between variability in central foveal thickness (CFT) and vision with ranibizumab in a HARBOR post hoc analysis. Methods and analysis Patients with neovascular age-related macular degeneration (nAMD; N=1097) received ...
V. Sheth +3 more
semanticscholar +1 more source
Clinical Characteristics of Neovascular Age-Related Macular Degeneration without Typical Drusen
Journal of Ophthalmology, 2021 Purpose. To evaluate the clinical characteristics of neovascular age-related macular degeneration (nAMD) patients without typical drusen. Methods. We retrospectively studied 165 eyes in 165 patients with treatment-naïve nAMD, including typical AMD and ...
Hiroyuki Kamao +5 more
doaj +1 more source
Scientific Reports, 2022 The phenotypes of neovascular age-related macular degeneration (nAMD) are recognized as differing between Caucasian and Asian patients. Pachychoroid is thought to be more prevalent in Asians than in Caucasians, and may be involved in the development of ...
Hidetaka Matsumoto +5 more
doaj +1 more source
A model to quantify the influence of treatment patterns and optimize outcomes in nAMD
Scientific Reports, 2022 Neovascular age-related macular degeneration (nAMD) is a progressive retinal disease that often leads to severe and permanent vision loss. Early initiation of anti-vascular endothelial growth factor (anti-VEGF) therapy has been shown to preserve vision ...
F. Ziemssen +9 more
semanticscholar +1 more source
Gaussian Accelerated Molecular Dynamics in NAMD
Journal of Chemical Theory and Computation, 2016 Gaussian accelerated molecular dynamics (GaMD) is a recently developed enhanced sampling technique that provides efficient free energy calculations of biomolecules. Like the previous accelerated molecular dynamics (aMD), GaMD allows for "unconstrained" enhanced sampling without the need to set predefined collective variables and so is useful for ...
Yui Tik Pang +3 more
openaire +4 more sources