Results 101 to 110 of about 841 (115)

Targeted Degradation of EGFR Mutations via Self-Delivery Nano-PROTACs for Boosting Tumor Synergistic Immunotherapy

ACS Applied Materials & Interfaces
Proteolysis targeting chimera (PROTAC) has recently emerged as a promising strategy to selectively degrade target proteins in the treatment of various diseases. However, it has low bioavailability due to strong hydrophobicity, poor membrane permeability, and nonspecific distribution in vivo, which greatly limits its application.
Xuechun Wang, Jie Yan, Yilei Zhao, Songyan Li, Zilin Ma, Xiuying Duan, Yuelan Wang, Jianwei Jiao, Changping Gu, Guiqiang Zhang   +9 more
openaire   +2 more sources

Targeted degradation of hexokinase 2 by a novel engineered bispecific chimeric liposome-based Nano-PROTACs for enhancing tumor chemotherapy

Biomaterials
Aerobic glycolysis is critical for tumor development and metastasis. Regulating the activity of vital metabolic enzymes in the tumor glycolysis process, such as hexokinase 2 (HK-2), is expected for tumor treatment. However, conventional small molecule inhibitors only block the activity of proteases with consistently high doses via occupation-driven ...
Linlin Gong, Shasha Li, Jiahui Sun, Runjie Liu, Jianling Wang, Simeng Wang, Yuelei Zhao, Li Yan, Meiju Ji, Dan Yang, Peng Hou, Dechun Liu   +11 more
openaire   +2 more sources

Correction to “Self-Assembled Nano-PROTAC Enables Near-Infrared Photodynamic Proteolysis for Cancer Therapy”

Journal of the American Chemical Society, 2023
Weishan Wang, Chenghong Zhu, Bin Zhang, Yi Feng, Yan Zhang, Jinbo Li   +5 more
openaire   +1 more source

Nano Proteolysis Targeting Chimeras (PROTACs) with Anti‐Hook Effect for Tumor Therapy

Angewandte Chemie - International Edition, 2023
Da-Yong Hou, Hong-Wei An, Hao Wang
exaly  

CDK4/6 nano-PROTAC enhances mitochondria-dependent photodynamic therapy and anti-tumor immunity

Nano Today, 2023
Tianyi Wang, Yaming Zhang, Kang Chen, Yi Huang, Yuwei Liu, Shuting Xu, Weiping Wang   +6 more
openaire   +1 more source

Checkpoint Nano‐PROTACs for Activatable Cancer Photo‐Immunotherapy

Advanced Materials, 2023
Shasha He, Kanyi Pu
exaly  

Non-small molecule PROTACs (NSM-PROTACs): Protein degradation kaleidoscope

Acta Pharmaceutica Sinica B, 2022
Xiao-Li Xu, Qi-Dong You, Zheng-Yu Jiang
exaly  

Targeted Degradation of PD‐L1 and Activation of the STING Pathway by Carbon‐Dot‐Based PROTACs for Cancer Immunotherapy

Angewandte Chemie - International Edition, 2023
Yan-Feng Gao, Hai Wang
exaly  

2D-PROTACs with augmented protein degradation for super-resolution photothermal optical coherence tomography guided momentary multimodal therapy

Chemical Engineering Journal, 2022
Hao Liu, Zhiming Liu
exaly  

Current advances and development strategies of orally bioavailable PROTACs

European Journal of Medicinal Chemistry, 2023
shenxin zeng
exaly