Results 91 to 100 of about 18,503 (241)

β‐Adducin Restrains PLA2G4A‐Dependent Lysosomal Membrane Permeabilization and Neuronal Death in Ischemic Stroke

Advanced Science, EarlyView.
This study identifies β‐adducin as a regulator of lysosomal integrity in ischemic neurons. Ischemia‐associated FTO loss increases m6A modification and destabilizes Add2 mRNA, reducing β‐adducin expression and promoting PLA2G4A accumulation at lysosomes.
Hui‐qin Li, Pin‐yi Liu, Dan Wu, Fei‐yu Ma, Yi Bai, Sheng‐nan Xia, Hai‐yan Yang, Xin‐yu Bao, Yun Xu, Xiang Cao   +9 more
wiley   +1 more source

Innovative CDR grafting and computational methods for PD-1 specific nanobody design

Frontiers in Bioinformatics
IntroductionThe development of nanobodies targeting Programmed Cell Death Protein-1 (PD-1) offers a promising approach in cancer immunotherapy. This study aims to design and characterize a PD-1-specific nanobody using an integrated computational and ...
Jagadeeswara Reddy Devasani, Girijasankar Guntuku, Nalini Panatula, Murali Krishna Kumar Muthyala, Mary Sulakshana Palla, Teruna J. Siahaan   +5 more
doaj   +1 more source

Humanized CD7 nanobody-based immunotoxins exhibit promising anti-T-cell acute lymphoblastic leukemia potential

, 2017
Yuan Yu,1–3 Jialu Li,1–3 Xuejun Zhu,4 Xiaowen Tang,2,5 Yangyi Bao,6 Xiang Sun,6 Yuhui Huang,1,2 Fang Tian,4 Xiaomei Liu,1,2 Lin Yang1–3 1The Cyrus Tang Hematology Center, 2Collaborative Innovation Center of Hematology, Soochow ...
Liu X, Li J, Huang Y, Tian F, Yang L, Bao Y, Zhu X, Sun X, Yu Y, Tang X   +9 more
core  

Nanobody-based bispecific T-cell engager (Nb-BiTE): a new platform for enhanced T-cell immunotherapy

Signal Transduction and Targeted Therapy, 2023
Xiao-mei Yang, Xuan-dong Lin, Wei Shi, Shen-xia Xie, Xia-ning Huang, Shi-hua Yin, Xiao-bing Jiang, Bruce D. Hammock, Zhi Ping Xu, Xiao-ling Lu   +9 more
doaj   +1 more source

NanoBinder: a machine learning assisted nanobody binding prediction tool using Rosetta energy scores

Journal of Cheminformatics
Nanobodies offer significant therapeutic potential due to their small size, stability, and versatility. Although advancements in computational protein design have made designing de novo nanobodies increasingly feasible, there are limited tools ...
Palistha Shrestha, Chandana S. Talwar, Jeevan Kandel, Kwang-Hyun Park, Kil To Chong, Eui-Jeon Woo, Hilal Tayara   +6 more
doaj   +1 more source

Nanobody‑based Pannexin1 channel inhibitors

Nanobody‑based Pannexin1 channel inhibitors increase survival after cardiac ischemia ...
Kwak, Brenda
core   +1 more source

Analysing hot spots in nanobody-antigen complexes

, 2023
Nanotelesa so proteini izvedeni iz posebne vrste imunoglobulinov, ki imajo samo težko verigo in imajo zaradi tega posebne lastnosti. Dodaten vpogled v način prepoznave antigenov z nanotelesi lahko dobimo z analizo energijsko močnejših interakcij (ang ...
Zgonik, Timotej
core  

Metal nanostructure‐coupled label‐free localized surface plasmon resonance biosensors for rapid and sensitive disease diagnosis

BMEMat, EarlyView.
LSPR biosensing enables rapid, sensitive, and low‐sample‐volume detection of biomarkers, with broad applications in diagnosing cancer, infectious, and chronic diseases. Advances in nanostructure design, micro/nanofabrication, and microfluidic integration have expanded the potential of LSPR sensors in biomedical diagnostics.
Zhaoxin Geng, Yunfei Sha, Jiongyan Yang, Hongru Yang, Xiao Liang   +4 more
wiley   +1 more source

From pathogen to “living drug factory” innovative strategies and clinical translation of bacteria as programmable intelligent vectors for cancer therapy

BMEMat, EarlyView.
Engineered bacteria serve as smart, living therapeutics that target tumors, deliver drugs, and remodel immunosuppressive microenvironments. This review highlights their potential to potentiate immunotherapy, radiotherapy, and chemotherapy, offering a promising paradigm for precise and synergistic cancer treatment. Abstract The dynamic interplay between
Haonan Shen, Weichen Zhang, Gaoli Niu, Li Wang, Ruiyan Li, Yueyue Fan, Feixue Lu, Lingling Xu, Xiaoyuan Ji, Yong Kang   +9 more
wiley   +1 more source

Preparation of a Nanobody Specific to Dectin 1 and Its Anti-inflammatory Effects on Fungal Keratitis

International Journal of Nanomedicine, 2022
Xing Liu,1 Jianxin Sui,2 Cui Li,1 Xudong Peng,1 Qian Wang,1 Nan Jiang,1 Qiang Xu,1 Luokai Wang,2 Jing Lin,1 Guiqiu Zhao1 1Department of Ophthalmology, Affiliated Hospital of Qingdao University, Qingdao, People’s Republic of China; 2College of Food ...
Liu X, Sui J, Li C, Peng X, Wang Q, Jiang N, Xu Q, Wang L, Lin J, Zhao G   +9 more
doaj