Results 81 to 90 of about 16,460 (261)

Immune cell landscapes are associated with high-grade serous ovarian cancer survival

Scientific Reports
High-grade serous ovarian cancer (HGSOC) is an aggressive disease known to develop resistance to chemotherapy. We investigated the prognostic significance of tumor cell states and potential mechanisms underlying chemotherapy resistance in HGSOC ...
Guoan Zhang, Yan Zhang, Jingjing Zhang, Xiaohui Yang, Wenjie Sun, Ying Liu, Yingfu Liu   +6 more
doaj   +1 more source

Recombinant PASylated nanobody probes with improved blood circulation and tumor targeting

Journal of Innovative Optical Health Sciences
Nanobodies have been extensively demonstrated in biomedical imaging and therapy. However, nanobody probes often suffer from rapid renal clearance due to its small size.
Yicheng Yang, Lingyue Jin, You Zhang, Siyu Zhou, Weijun Wei, Gang Huang, Changfeng Wu   +6 more
doaj   +1 more source

NANOBODY® Molecule, a Giga Medical Tool in Nanodimensions

, 2023
Although antibodies remain the most widely used tool for biomedical research, antibody technology is not flawless. Innovative alternatives, such as Nanobody® molecules, were developed to address the shortcomings of conventional antibodies.
Laetitia Seguin, Sarah Kunz, Chloe C. Feral, Manon Durandy   +3 more
core   +1 more source

Epitope‐Resolved Digital SERS Profiling of Structurally Dynamic Antigens via a Multi‐Epitope Bispecific Antibody Framework

Advanced Science, EarlyView.
A multi‐epitope digital surface‐enhanced Raman spectroscopy framework enables epitope‐resolved immunoprofiling by integrating bispecific antibody fragments with spectrally encoded nanotags. This approach decouples binding events into independent digital channels, allowing structure‐aware antigen analysis.
Jing Wang, Quan Zhou, Kym Lowry, Christopher B. Howard, Matt Trau   +4 more
wiley   +1 more source

Preparative purification of T2/nanobody complexes.

, 2013
Purified T2 channel was incubated with an excess of nanobody (e.g. nanobody 18) prior to preparative gel filtration. Fractions containing channel protein and the nanobody were combined and used for crystallization studies.
Pär Nordlund (161768), Yin Hoe Yau (113342), Lisa Wåhlin (474648), Christian Löw (320481), Per Moberg (320483), Jan Steyaert (58922), Caroline Jegerschöld (320482), Esben M. Quistgaard (444925), Els Pardon (206973), Susana Geifman-Shochat (112085)   +9 more
core   +1 more source

A Brain‐Penetrant Nanobody Reveals GSK3β‐Driven Proline‐Directed Phosphorylation as a Master Regulator of Ischemic Neurodegeneration

Advanced Science, EarlyView.
A brain‐targeted nanoparticle enables delivery of a therapeutic nanobody (Nb.29E9) that inhibits pathogenic GSK3β signaling. This intervention restores AMPK/mTORC1/TGFβ homeostasis, attenuates neuroinflammation and oxidative stress, and promotes long‐term functional recovery after ischemic stroke.
Lan Li, Muyang Li, Lei Sun, Ying Yang, Yuanshun Wu, Ziyi Yin, Anni Wang, Peiyang Zhou, Shaoxiang Luo, Jian Chen, Jun Qin, Zhibing Ai, Zilong Yuan, Zhiqiang Dong, Min Zhang   +14 more
wiley   +1 more source

A novel anti-CTLA-4 nanobody-IL12 fusion protein in combination with a dendritic cell/tumour fusion cell vaccine enhances the antitumour activity of CD8+ T cells in solid tumours

Journal of Nanobiotechnology
Background We previously developed a nanobody targeting CTLA-4 and demonstrated that it can boost antitumour T-cell responses in vitro; however, the resulting responses after the injection of T cells into cancer models are usually weak and transient ...
Meng-jie Jiang, Hao-peng Cui, Ting-ting Li, Xiao-mei Yang, Xiao-ling Lu, Ai-qun Liu   +5 more
doaj   +1 more source

Endobody: Genetically Encodable Nanobody‐CPP Chimeras for Degradation of Membrane and Extracellular Proteins

Advanced Science, EarlyView.
We introduced genetically encodable, receptor‐independent nanobody‐CPP chimeras, termed endobodies, as robust and modular membrane protein degraders. Additionally, proteasome‐targeting domain (PTD)‐tethered endobody demonstrates further enhanced degradation potency.
Chengjian Zhou, Huiping He, Simin Xia, Xi Chen   +3 more
wiley   +1 more source

Nanomaterials for Allergy Diagnosis and Treatment: Advances, Opportunities and Translational Challenges

Advanced Science, EarlyView.
Nanomaterials offer dual applications in allergy management. For diagnosis, nanomaterials enhance analytical sensitivity and improve detection in specific IgE and functional assays such as the basophil activation test (BAT). For allergen‐specific immunotherapy, nanomaterials enable allergen masking and controlled release, and effectively modulate the ...
Madiha Habib, Shan Jiang, Joyce ZX Lee, CW Lim, HL Yeung, Nicki YH Leung, Patrick SC Leung, Ting F Leung, Christine YY Wai   +8 more
wiley   +1 more source

Evaluation of the yeast surface display system for screening of functional nanobodies

AMB Express, 2020
Yeast surface display is a powerful technology used to isolate and engineer proteins to improve their activity, specificity, and stability. In this method, gene expression is regulated by promoters, and secretion efficiency is affected by secretion ...
Kaho Kajiwara, Wataru Aoki, Mitsuyoshi Ueda   +2 more
doaj   +1 more source