Results 301 to 310 of about 19,829 (313)

Nanobody pharmacology

Science Signaling
Antibody fragments can act as pharmacological tools to modulate the functions of G protein–coupled receptors.
openaire   +2 more sources

Isolation of Antigen-Specific Nanobodies

2010
Recombinant Nanobodies, derived from camelid heavy-chain antibodies, are a unique form of monoclonal antibodies composed of a single antigen-binding domain. Nanobodies are the smallest intact antigen-binding entities that can be derived from an in vivo affinity-matured antibody.
Hassanzadeh Ghassabeh, Gholamreza, Saerens, Dirk, Muyldermans, Serge   +2 more
openaire   +3 more sources

Optogenetic Activation of Intracellular Nanobodies

2022
Intracellular antibody fragments such as nanobodies and scFvs are powerful tools for imaging and for modulating and neutralizing endogenous target proteins. Optogenetically activated intracellular antibodies (optobodies) constitute a light-inducible system to directly control intrabody activities in cells, with greater spatial and temporal resolution ...
Daseuli, Yu, Heo, Won Do
openaire   +2 more sources

Nanobodies in therapeutic applications.

Current opinion in molecular therapeutics, 2007
Over the years, many antibodies have been successfully generated to treat patients with life-threatening diseases, most notably cancer. While the first generation of antibodies, originating from mice, caused severe side effects and were relatively inefficient, technological advances have made it possible to obtain fully human antibodies for therapeutic
Roovers, Rob C., Van Dongen, G. A M S, Van Bergen En Henegouwen, P. M P   +2 more
openaire   +3 more sources

Nanobodies^®: proficient tools in diagnostics

Expert Review of Molecular Diagnostics, 2010
With the advent of new antibody engineering technologies, conventional antibodies have been minimized into smaller antibody formats. Small size is an important advantage for current and future diagnostic development. Nanobodies® (Ablynx) are among the smallest known antigen-binding antibody fragments, and are derived from the heavy-chain only ...
Huang, Lieven, Muyldermans, Serge, Saerens, Dirk   +2 more
openaire   +3 more sources

Nanobodies: The ultrasmall antibodies

New Scientist, 2007
The blood of camels has revealed how to make tiny antibodies that can go where no antibody has gone before.
openaire   +2 more sources

A new strategy to generate nanobodies for the coumaphos based on the synthesized nanobody libraries

Food Chemistry
To break through the bottleneck in preparation of nanobody (Nb) for chemical contaminants induced by the difficulties in the synthesis of immunogen, complexity and unexpectable efficiency of immunization, a novel strategy to generate Nbs based on the designed synthetic Nb libraries with final size up to 109 cfu/mL was adopted and succeeded in selection
Ruyu, Fang, Yingxue, Li, Fei, Liu, Yifan, Liang, Yu, Wang, Guohua, Zhong, Zhenlin, Xu, Bruce D, Hammock, Hong, Wang   +8 more
openaire   +2 more sources

Identification of a CEACAM5 targeted nanobody for positron emission tomography imaging and near-infrared fluorescence imaging of colorectal cancer

European Journal of Nuclear Medicine and Molecular Imaging, 2023
Yitai Xiao, Chaoming Mei, Duo Xu, Fan Yang, Meilin Yang, Lei Bi, Junjie Mao, P. Pang, Dan Li   +8 more
semanticscholar   +1 more source

Advances in Nanobodies

Journal of Nanoscience and Nanotechnology, 2016
Xiaoling Lu, Yong Huang, Liu Liang, Zixi Hu, Yongxiang Zhao, Yingying Huang, Jian He, Siliang Duan   +7 more
openaire   +2 more sources

Nanobody-functionalized polymersomes

Journal of Controlled Release, 2015
Tao Zou, Min-Hui Li, Ario de Marco, Anne Beugnet, Fatimata Dembele, Lucie Sengmanivong   +5 more
openaire   +3 more sources