Pre-treatment With PLGA/Silibinin Nanoparticles Mitigates Dacarbazine-Induced Hepatotoxicity
Frontiers in Bioengineering and Biotechnology, 2020 Drug-induced hepatotoxicity is one of the major barriers limiting application of current pharmaceuticals as well as clinical translation of novel and perspective drugs. In this context, numerous hepatoprotective molecules have been proposed to prevent or
Mikhail Durymanov +3 more
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RNA Combined with Nanoformulation to Advance Therapeutic Technologies
, 2023 Nucleic acid-based therapies have the potential to address numerous diseases that pose significant challenges to more traditional methods. RNA-based therapies have emerged as a promising avenue, utilizing nanoformulation treatments to target a range of ...
Mariana Evangelista Bandeira +11 more
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Prospects of Curcumin Nanoformulations in Cancer Management [PDF]
Molecules, 2022 There is increasing interest in the use of natural compounds with beneficial pharmacological effects for managing diseases. Curcumin (CUR) is a phytochemical that is reportedly effective against some cancers through its ability to regulate signaling pathways and protein expression in cancer development and progression. Unfortunately, its use is limited
Hilda Amekyeh +3 more
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Nanoformulation of peptides using CrEL and their characterization.
, 2023 (A) Chemical structures of KS-133 and CrEL. In the molecular structure of CrEL, the hydrophilic moiety is highlighted in light blue, and the hydrophobic moiety is presented in orange.
Akumwami Steeve (16496597) +7 more
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New food preservation candidate Zataria multiflora dendrimer synthesis and antimicrobial assessment [PDF]
Archives of Razi InstituteIt is widely recognized for its antibacterial and antioxidant characteristics. Zataria multiflora, also known as ZTM, is a prominent botanical species. Thus, it serves as a superb alternative to goods containing artificial preservatives. Consequently, it
Rohallah Ghasemi +2 more
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Potent Tetrahydroquinolone Eliminates Apicomplexan Parasites
Frontiers in Cellular and Infection Microbiology, 2020 Apicomplexan infections cause substantial morbidity and mortality, worldwide. New, improved therapies are needed. Herein, we create a next generation anti-apicomplexan lead compound, JAG21, a tetrahydroquinolone, with increased sp3-character to improve ...
Martin J. McPhillie +34 more
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Euphorbia characias Extract: Inhibition of Skin Aging-Related Enzymes and Nanoformulation
Plants, 2022 Plant extracts have long served as important sources of bioactive compounds, and they are currently the focus of extensive research in the development of novel preventive and therapeutic strategies. However, their health benefits are often limited by low
Francesca Pintus +6 more
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Nanodelivery of Dietary Polyphenols for Therapeutic Applications
Molecules, 2022 Advancement in nanotechnology has unleashed the therapeutic potentials of dietary polyphenols by enhancing bioavailability, improving biological half-life, and allowing site-specific drug delivery.
Mithun Rudrapal +13 more
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Nanoformulation of the Superoxide Dismutase Mimic, MnTnBuOE-2-PyP5+, Prevents its Acute Hypotensive Response [PDF]
, 2020 Scavenging superoxide (O2•-) via overexpression of superoxide dismutase (SOD) or administration of SOD mimics improves outcomes in multiple experimental models of human disease including cardiovascular disease, neurodegeneration, and cancer.
Schlichte, Sarah L. +7 more
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FTY720 Nanoformulation Induces O‑GlcNacylation of Synuclein to Alleviate Synucleinopathy
, 2023 The post-translational modification and aggregation of alpha-synuclein are one of the major causes of Parkinson’s disease (PD) regulation. In that, the phosphorylation and nitration of synuclein elevate the aggregation, while O-GlcNacylation prevents the
Subhasree Roy Choudhury (12524142) +4 more
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