Results 1 to 10 of about 3,520 (152)
Vaccines, 2023 Virus-specific antibodies are crucial for protective immunity against SARS-CoV-2. Assessing functional antibodies through conventional or pseudotyped virus neutralisation tests (pVNT) requires high biosafety levels.
Stephan Ludwig +2 more
exaly +5 more sources
Viruses, 2021 Porcine deltacoronavirus (PDCoV), an emerging enteropathogenic coronavirus, causes diarrhoea in suckling piglets and has the potential for cross-species transmission. No effective PDCoV vaccines or antiviral drugs are currently available.
Shaobo Xiao, He Sun, Liurong Fang
exaly +4 more sources
NanoFIRE: A NanoLuciferase and Fluorescent Integrated Reporter Element for Robust and Sensitive Investigation of HIF and Other Signalling Pathways [PDF]
Biomolecules, 2023 The Hypoxia Inducible Factor (HIF) transcription factors are imperative for cell adaption to low oxygen conditions and development; however, they also contribute to ischaemic disease and cancer.
Michael Beard +2 more
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Viruses, 2021 Porcine epidemic diarrhea virus (PEDV) is the predominant cause of an acute, highly contagious enteric disease in neonatal piglets. There are currently no approved drugs against PEDV infection.
Qigai He, Rui Luo
exaly +4 more sources
Nanoluciferase Reporter Zika Viruses as Tools for Assessing Infection Kinetics and Antibody Potency
Viruses, 2023 Zika virus (ZIKV) has become endemic in multiple tropical and subtropical regions and has the potential to become widespread in countries with limited prior exposure to this infection.
Evi B Struble +2 more
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Development of a novel NanoBRET high-throughput drug screening assay for human GnRH receptor using sulfo-cyanine 5 fluorophore [PDF]
Journal of Pharmaceutical AnalysisG protein-coupled receptors (GPCRs), the largest superfamily of cell surface receptors and targets for over 30% of current clinical drugs, remain crucial for future therapeutic development.
Li Shen +8 more
doaj +2 more sources
Viruses, 2023 SARS-CoV-2 is a positive-strand RNA virus in the Coronaviridae family that is responsible for morbidity and mortality worldwide. To better understand the molecular pathways leading to SARS-CoV-2 virus assembly, we examined a virus-like particle (VLP ...
Gullberg Rebekah, Judith Frydman
exaly +3 more sources
Protocol for Measuring Drug–Target Engagement in Mouse Colorectal Cancer Organoids Using NanoBRET Assay [PDF]
Bio-ProtocolOrganoids as a drug discovery platform represent an emerging field that continues to refine its tools. NanoBRET (bioluminescence resonance energy transfer) has emerged as a proximity-based and highly sensitive assay to measure protein–protein and protein–
Hammed Badmos, Colin Steele, Ross Cagan
doaj +2 more sources
Frontiers in Microbiology, 2021 Senecavirus A (SVA), also known as Seneca Valley virus, is a recently emerged picornavirus that can cause swine vesicular disease, posing a great threat to the global swine industry.
Xiaoran Guo +8 more
doaj +1 more source
Frontiers in Pharmacology, 2023 Background: Adenosine A1 receptor (A1AR) plays a prominent role in neurological and cardiac diseases and inflammatory processes. Its endogenous ligand adenosine is known to be one of the key players in the sleep–wake cycle.
Luisa Saecker +2 more
doaj +1 more source