Results 31 to 40 of about 6,273 (276)

Preparation and Carbonization of Glucose and Pyromellitic Dianhydride Crosslinked Polymers

C, 2021
In this work, four types of nanosponges were prepared from pyromellitic dianhydride (PMDA) and D-glucose (GLU) with different molar ratios (1.5:1, 2:1, 2.5:1 and 3:1).
Fabrizio Caldera, Antonella Moramarco, Federico Cesano, Anastasia Anceschi, Alessandro Damin, Marco Zanetti   +5 more
doaj   +1 more source

Synthesis and Characterization of Carboxymethyl Chitosan Nanosponges with Cyclodextrin Blends for Drug Solubility Improvement

Gels, 2022
This study aimed to enhance the solubility and release characteristics of docetaxel by synthesizing highly porous and stimuli responsive nanosponges, a nano-version of hydrogels with the additional qualities of both hydrogels and nano-systems ...
Syeda Sadia Batool Rizvi, Naveed Akhtar, Muhammad Usman Minhas, Arshad Mahmood, Kifayat Ullah Khan   +4 more
doaj   +1 more source

Glutathione Bioresponsive Cyclodextrin Nanosponges [PDF]

ChemPlusChem, 2015
AbstractCyclodextrin‐based nanosponges are designed as new nanostructured material for drug delivery. In vitro and in vivo studies show that nanosponges can increase the effectiveness of anti‐cancer drugs encapsulated within their nanostructure. Reported is a new, cheap glutathione (GSH)‐responsive material easily obtained in high yield through a one ...
TROTTA, Francesco, CALDERA, FABRIZIO, DIANZANI, Chiara, ARGENZIANO, MONICA, BARRERA, Giuseppina, CAVALLI, Roberta   +5 more
openaire   +4 more sources

Design and optimization of topical terbinafine hydrochloride nanosponges: Application of full factorial design, in vitro and in vivo evaluation

Journal of Advanced Pharmaceutical Technology & Research, 2020
Terbinafine hydrochloride (THCl) has a broad-spectrum antifungal activity. THCl has oral bioavailability 40%, which increases dosing frequency of the drug, thus leads to some systemic side effects.
Reham I Amer, Ghada H El-Osaily, Sameh S Gad   +2 more
doaj   +1 more source

Nanosponge: An Overview

Asian Journal of Pharmaceutical Research and Development, 2023
The "Pharmaceutical Nanotechnology" subfield of pharmaceutical sciences, which is now in its infancy, offers new tools, prospects, and horizons with potential applications in the field of therapy and diagnostics of disease. Pharmaceutical nanotechnology consists of items that are nanosized and may be altered in many ways to enhance their properties ...
Varda Joshi, Nikita Bhosale, Poonam Raut
openaire   +1 more source

Nanosponges for Drug Delivery and Cancer Therapy: Recent Advances

Nanomaterials, 2022
Nanosponges with three-dimensional (3D) porous structures, narrow size distribution, and high entrapment efficiency are widely engineered for cancer therapy and drug delivery purposes.
Siavash Iravani, Rajender S. Varma
doaj   +1 more source

Design Strategies for Cellular Nanosponges as Medical Countermeasures

BME Frontiers, 2023
The interest in using therapeutic nanoparticles to bind with harmful molecules or pathogens and subsequently neutralize their bioactivity has grown tremendously.
Shuyan Wang, Dan Wang, Mingxuan Kai, Wei-Ting Shen, Lei Sun, Weiwei Gao, Liangfang Zhang   +6 more
doaj   +1 more source

Exploring Cyclodextrin-Based Nanosponges as Drug Delivery Systems: Understanding the Physicochemical Factors Influencing Drug Loading and Release Kinetics. [PDF]

Int J Mol Sci
Cyclodextrin-based nanosponges (CDNSs) are complex macromolecular structures composed of individual cyclodextrins (CDs) and nanochannels created between cross-linked CD units and cross-linkers.
Pyrak B, Rogacka-Pyrak K, Gubica T, Szeleszczuk Ł.   +3 more
europepmc   +2 more sources

Fabrication and Biological Assessment of Antidiabetic α-Mangostin Loaded Nanosponges: In Vitro, In Vivo, and In Silico Studies

Molecules, 2021
Type 2 diabetes mellitus has been a major health issue with increasing morbidity and mortality due to macrovascular and microvascular complications. The urgent need for improved methods to control hyperglycemic complications reiterates the development of
Faisal Usman, Hamid Saeed Shah, Sumera Zaib, Sirikhwan Manee, Jahanzeb Mudassir, Ajmal Khan, Gaber El-Saber Batiha, Khamael M. Abualnaja, Dalal Alhashmialameer, Imtiaz Khan   +9 more
doaj   +1 more source

Weak complexation of 5-fluorouracil with β-cyclodextrin, carbonate, and dianhydride crosslinked β-cyclodextrin: in vitro and in silico studies

Research in Pharmaceutical Sciences, 2022
Background and purpose: Several pharmaceutical formulations were investigated to improve the solubility of 5-fluorouracil to enhance bioavailability and therapeutic efficacy. This study aimed to examine the potential use of cyclodextrin-based nanosponges
Hadeia Mashaqbeh, Rana Obaidat, Nizar A Al-Shar’i, Tamam El-Elimat, Soraya Alnabulsi   +4 more
doaj   +1 more source