Results 21 to 30 of about 3,496 (213)

Glutathione Bioresponsive Cyclodextrin Nanosponges [PDF]

ChemPlusChem, 2015
AbstractCyclodextrin‐based nanosponges are designed as new nanostructured material for drug delivery. In vitro and in vivo studies show that nanosponges can increase the effectiveness of anti‐cancer drugs encapsulated within their nanostructure. Reported is a new, cheap glutathione (GSH)‐responsive material easily obtained in high yield through a one ...
TROTTA, Francesco, CALDERA, FABRIZIO, DIANZANI, Chiara, ARGENZIANO, MONICA, BARRERA, Giuseppina, CAVALLI, Roberta   +5 more
openaire   +4 more sources

Design and optimization of topical terbinafine hydrochloride nanosponges: Application of full factorial design, in vitro and in vivo evaluation

Journal of Advanced Pharmaceutical Technology & Research, 2020
Terbinafine hydrochloride (THCl) has a broad-spectrum antifungal activity. THCl has oral bioavailability 40%, which increases dosing frequency of the drug, thus leads to some systemic side effects.
Reham I Amer, Ghada H El-Osaily, Sameh S Gad   +2 more
doaj   +1 more source

Nanosponge: An Overview

Asian Journal of Pharmaceutical Research and Development, 2023
The "Pharmaceutical Nanotechnology" subfield of pharmaceutical sciences, which is now in its infancy, offers new tools, prospects, and horizons with potential applications in the field of therapy and diagnostics of disease. Pharmaceutical nanotechnology consists of items that are nanosized and may be altered in many ways to enhance their properties ...
Varda Joshi, Nikita Bhosale, Poonam Raut
openaire   +1 more source

Design Strategies for Cellular Nanosponges as Medical Countermeasures

BME Frontiers, 2023
The interest in using therapeutic nanoparticles to bind with harmful molecules or pathogens and subsequently neutralize their bioactivity has grown tremendously.
Shuyan Wang, Dan Wang, Mingxuan Kai, Wei-Ting Shen, Lei Sun, Weiwei Gao, Liangfang Zhang   +6 more
doaj   +1 more source

Fabrication and Biological Assessment of Antidiabetic α-Mangostin Loaded Nanosponges: In Vitro, In Vivo, and In Silico Studies

Molecules, 2021
Type 2 diabetes mellitus has been a major health issue with increasing morbidity and mortality due to macrovascular and microvascular complications. The urgent need for improved methods to control hyperglycemic complications reiterates the development of
Faisal Usman, Hamid Saeed Shah, Sumera Zaib, Sirikhwan Manee, Jahanzeb Mudassir, Ajmal Khan, Gaber El-Saber Batiha, Khamael M. Abualnaja, Dalal Alhashmialameer, Imtiaz Khan   +9 more
doaj   +1 more source

Synthesis and evaluation of B-cyclodextrin Based Nanosponges of 5- Fluorouracil by Using Ultrasound Assisted Method

Iraqi Journal of Pharmaceutical Sciences, 2020
CD-nanosponges were prepared by crosslinking B-CD with diphenylcarbonate (DPC) using ultrasound assisted technique. 5-FU was incorporated with NS by freeze drying, and the phase solubility study, complexation efficiency (CE) entrapment efficiency were ...
Ihsan K. Jasim, Shaimaa N. Abd Alhammid, Alaa A. Abdulrasool   +2 more
doaj   +1 more source

Bioinspired Heparin Nanosponge Prepared by Photo-crosslinking for Controlled Release of Growth Factors [PDF]

, 2017
Indexación: Scopus.Growth factors have great therapeutic potential for various disease therapy and tissue engineering applications. However, their clinical efficacy is hampered by low bioavailability, rapid degradation in vivo and non-specific ...
Choi, Won Il, Jo, Seong-Min, Kamaly, Nazila, Lee, Jin Hyung, Sahu, Abhishek, Tae, Giyoong, Vilos, Cristian   +6 more
core   +2 more sources

Weak complexation of 5-fluorouracil with β-cyclodextrin, carbonate, and dianhydride crosslinked β-cyclodextrin: in vitro and in silico studies

Research in Pharmaceutical Sciences, 2022
Background and purpose: Several pharmaceutical formulations were investigated to improve the solubility of 5-fluorouracil to enhance bioavailability and therapeutic efficacy. This study aimed to examine the potential use of cyclodextrin-based nanosponges
Hadeia Mashaqbeh, Rana Obaidat, Nizar A Al-Shar’i, Tamam El-Elimat, Soraya Alnabulsi   +4 more
doaj   +1 more source

Transport properties of ibuprofen encapsulated in cyclodextrin nanosponge hydrogels: A proton HR-MAS NMR spectroscopy study [PDF]

, 2016
The chemical cross-linking of β-cyclodextrin (β-CD) with ethylenediaminetetraacetic dianhydride (EDTA) led to branched polymers referred to as cyclodextrin nanosponges (CDNSEDTA).
Castiglione, Franca, Ferro, Monica, Mele, Andrea, Melone, Lucio, Panzeri, Walter, Punta, Carlo, Rossi, Barbara, Trotta, Francesco   +7 more
core   +2 more sources

Optimisation of a Greener-Approach for the Synthesis of Cyclodextrin-Based Nanosponges for the Solubility Enhancement of Domperidone, a BCS Class II Drug

Pharmaceuticals, 2023
BCS class II molecules suffer from low oral bioavailability because of their poor permeability and sub-optimal aqueous solubility. One of the approaches to enhance their bioavailability is using cyclodextrin-based nanosponges.
Mohit Vij, Neha Dand, Lalit Kumar, Pankaj Wadhwa, Shahid Ud Din Wani, Wael A. Mahdi, Sultan Alshehri, Prawez Alam, Faiyaz Shakeel   +8 more
doaj   +1 more source