Results 21 to 30 of about 2,413 (208)

Cellular Nanosponges Inhibit SARS-CoV‑2 Infectivity [PDF]

, 2020
We report cellular nanosponges as an effective medical countermeasure to the SARS-CoV-2 virus. Two types of cellular nanosponges are made of the plasma membranes derived from human lung epithelial type II cells or human macrophages.
Fang, Ronnie H, Zhang, Liangfang, Griffiths, Anthony, Zhou, Jiarong, Honko, Anna, Vasquez, Jhonatan Henao, Gong, Hua, Gao, Weiwei, Downs, Sierra N, Zhang, Qiangzhe   +9 more
core   +1 more source

Design and optimization of topical terbinafine hydrochloride nanosponges: Application of full factorial design, in vitro and in vivo evaluation

Journal of Advanced Pharmaceutical Technology & Research, 2020
Terbinafine hydrochloride (THCl) has a broad-spectrum antifungal activity. THCl has oral bioavailability 40%, which increases dosing frequency of the drug, thus leads to some systemic side effects.
Reham I Amer, Ghada H El-Osaily, Sameh S Gad   +2 more
doaj   +1 more source

Design Strategies for Cellular Nanosponges as Medical Countermeasures

BME Frontiers, 2023
The interest in using therapeutic nanoparticles to bind with harmful molecules or pathogens and subsequently neutralize their bioactivity has grown tremendously.
Shuyan Wang, Dan Wang, Mingxuan Kai, Wei-Ting Shen, Lei Sun, Weiwei Gao, Liangfang Zhang   +6 more
doaj   +1 more source

Fabrication and Biological Assessment of Antidiabetic α-Mangostin Loaded Nanosponges: In Vitro, In Vivo, and In Silico Studies

Molecules, 2021
Type 2 diabetes mellitus has been a major health issue with increasing morbidity and mortality due to macrovascular and microvascular complications. The urgent need for improved methods to control hyperglycemic complications reiterates the development of
Faisal Usman, Hamid Saeed Shah, Sumera Zaib, Sirikhwan Manee, Jahanzeb Mudassir, Ajmal Khan, Gaber El-Saber Batiha, Khamael M. Abualnaja, Dalal Alhashmialameer, Imtiaz Khan   +9 more
doaj   +1 more source

Effect of Ni/Rh ratios on characteristics of NixRhy nanosponges towards high-performance hydrogen evolution reaction

Data in Brief, 2019
The data presented in this article are related to the research article entitled “NiRh Nanosponges with Highly Efficient Electrocatalytic Performance for Hydrogen Evolution Reaction (N.-A. Nguyen et al., 2019) [1].
Ngoc-Anh Nguyen, Ho-Suk Choi
doaj   +1 more source

Weak complexation of 5-fluorouracil with β-cyclodextrin, carbonate, and dianhydride crosslinked β-cyclodextrin: in vitro and in silico studies

Research in Pharmaceutical Sciences, 2022
Background and purpose: Several pharmaceutical formulations were investigated to improve the solubility of 5-fluorouracil to enhance bioavailability and therapeutic efficacy. This study aimed to examine the potential use of cyclodextrin-based nanosponges
Hadeia Mashaqbeh, Rana Obaidat, Nizar A Al-Shar’i, Tamam El-Elimat, Soraya Alnabulsi   +4 more
doaj   +1 more source

Optimisation of a Greener-Approach for the Synthesis of Cyclodextrin-Based Nanosponges for the Solubility Enhancement of Domperidone, a BCS Class II Drug

Pharmaceuticals, 2023
BCS class II molecules suffer from low oral bioavailability because of their poor permeability and sub-optimal aqueous solubility. One of the approaches to enhance their bioavailability is using cyclodextrin-based nanosponges.
Mohit Vij, Neha Dand, Lalit Kumar, Pankaj Wadhwa, Shahid Ud Din Wani, Wael A. Mahdi, Sultan Alshehri, Prawez Alam, Faiyaz Shakeel   +8 more
doaj   +1 more source

Glutathione Bioresponsive Cyclodextrin Nanosponges [PDF]

ChemPlusChem, 2015
AbstractCyclodextrin‐based nanosponges are designed as new nanostructured material for drug delivery. In vitro and in vivo studies show that nanosponges can increase the effectiveness of anti‐cancer drugs encapsulated within their nanostructure. Reported is a new, cheap glutathione (GSH)‐responsive material easily obtained in high yield through a one ...
TROTTA, Francesco, CALDERA, FABRIZIO, DIANZANI, Chiara, ARGENZIANO, MONICA, BARRERA, Giuseppina, CAVALLI, Roberta   +5 more
openaire   +4 more sources

β-Cyclodextrin Nanosponges for Oral Drug Delivery of Anti-Hypertensive Drug

Medical Sciences Forum, 2022
Nicardipine (NC) is an antihypertensive drug indicated for treatment of high blood pressure and angina. It belongs to BCS class-II, having poor solubility and low oral bioavailability.
Ritika Prashant Khivansara, Sandhya Bajirao Jadhav, Varsha Daund, Atul Sherje   +3 more
doaj   +1 more source

NANOSPONGES: A REVIEW

International Journal of Applied Pharmaceutics, 2018
The recent advance in nanotechnology has lead to the development of targeted drug delivery system. However, targeting a molecule to a particular site using a drug delivery system effectively requires a specialized drug delivery system. The discovery of nanosponge has become a significant step in overcoming certain problems such as drug toxicity, poor ...
Himangshu Bhowmik, D. Nagasamy Venkatesh, Anuttam Kuila, Kammari Harish Kumar   +3 more
openaire   +2 more sources