Neurobiological and immunogenetic aspects of narcolepsy: Implications for pharmacotherapy.
Sleep Medicine Reviews, 2019 Excessive daytime sleepiness (EDS) and cataplexy are common symptoms of narcolepsy, a sleep disorder associated with the loss of hypocretin/orexin (Hcrt) neurons.
S. Szabo +4 more
semanticscholar +1 more source
Profiling the sleep architecture of ageing adults using a seven‐state continuous‐time Markov model
Journal of Sleep Research, Volume 34, Issue 2, April 2025.Summary Sleep is a complex biological process regulated by networks of neurons and environmental factors. As one falls asleep, neurotransmitters from sleep–wake regulating neurones work in synergy to control the switching of different sleep states throughout the night. As sleep disorders or underlying neuropathology can manifest as irregular switching,
Jonathon Jacobs +3 more
wiley +1 more source
Activity of Genes with Functions in Human Williams-Beuren Syndrome Is Impacted by Mobile Element Insertions in the Gray Wolf Genome. [PDF]
, 2018 In canines, transposon dynamics have been associated with a hyper-social behavioral syndrome, although the functional mechanism has yet to be described.
Aardema, Matthew L +5 more
core +2 more sources
Prevalence and Incidence of Narcolepsy in a U.S. Health Care Claims Database, 2008-2010.
Sleep, 2019 STUDY OBJECTIVES To determine the prevalence and incidence of narcolepsy using a large U.S. health care claims database. METHODS The Truven Health MarketScan Commercial Dissertation Database (THMCDD) was used to estimate prevalence and incidence of ...
Darren Scheer +5 more
semanticscholar +1 more source
Decrease of excessive daytime sleepiness after shunt treatment for normal pressure hydrocephalus
Journal of Sleep Research, Volume 34, Issue 2, April 2025.Summary Sleepiness and apathy are often reported in patients with normal pressure hydrocephalus. However, research on outcomes after shunt surgery has mainly focused on the classical triad symptoms, that is, gait, cognition, and bladder dysfunction. This study aimed to describe the effects of shunt treatment on excessive daytime sleepiness and whether ...
Simon Lidén +4 more
wiley +1 more source
Healthcare Burden and Productivity Loss Due to Narcolepsy in Sweden
Clocks & SleepBackground: Narcolepsy impacts both patients and society, yet there is limited data on its socioeconomic consequences. Methods: This retrospective longitudinal cohort study used pseudonymized patient-level data from Swedish registers and included ...
Anna Giertz +5 more
doaj +1 more source
Selective loss of GABAB receptors in orexin/hypocretin-producing neurons results in disrupted sleep/wakefulness architecture [PDF]
, 2007 We generated mice with a selective loss of GABAB receptors in orexin neurons. Orexin neurons in these GABAB1<sup>-/-(orexin)</sup> mice showed reduced responsiveness to GABA<sub>A</sub> receptor agonists due to a ...
Bernard Bettler +10 more
core +1 more source
Genetic ablation of orexin neurons in mice results in narcolepsy, hypophagia, and obesity.
Neuron, 2001 Orexins (hypocretins) are a pair of neuropeptides implicated in energy homeostasis and arousal. Recent reports suggest that loss of orexin-containing neurons occurs in human patients with narcolepsy.
J. Hara +10 more
semanticscholar +1 more source
Journal of Sleep Research, Volume 34, Issue 2, April 2025.Lemborexant 10 mg, a dual orexin‐receptor antagonist (DORA), did not elicit respiratory depressant effects, as measured by peripheral oxygen saturation (SpO2) or apnea–hypopnea index (AHI), in subjects with moderate‐to‐severe chronic obstructive pulmonary disease (COPD).
Jocelyn Y. Cheng +3 more
wiley +1 more source
Recent advances in treatment for narcolepsy
Therapeutic Advances in Neurological Disorders, 2019 Narcolepsy type 1 (NT1) is a chronic orphan disorder, caused by the selective and irreversible loss of hypocretin/orexin (ORX) neurons, by a probable autoimmune process.
L. Barateau, Y. Dauvilliers
semanticscholar +1 more source