Results 21 to 30 of about 3,781,173 (328)

The Slack Channel Deletion Causes Mechanical Pain Hypersensitivity in Mice

Frontiers in Molecular Neuroscience, 2022
The role of the Slack (also known as Slo2.2, KNa1.1, or KCNT1) channel in pain-sensing is still in debate on which kind of pain it regulates. In the present study, we found that the Slack–/– mice exhibited decreased mechanical pain threshold but normal ...
Ye Liu, Ye Liu, Ye Liu, Fang-Fang Zhang, Fang-Fang Zhang, Fang-Fang Zhang, Ying Song, Ying Song, Ying Song, Ran Wang, Ran Wang, Qi Zhang, Qi Zhang, Qi Zhang, Zhong-Shan Shen, Zhong-Shan Shen, Zhong-Shan Shen, Fei-Fei Zhang, Fei-Fei Zhang, Fei-Fei Zhang, Dan-Ya Zhong, Dan-Ya Zhong, Dan-Ya Zhong, Xiao-Hui Wang, Xiao-Hui Wang, Xiao-Hui Wang, Qing Guo, Qing Guo, Qing Guo, Qiong-Yao Tang, Qiong-Yao Tang, Qiong-Yao Tang, Zhe Zhang, Zhe Zhang, Zhe Zhang   +34 more
doaj   +1 more source

Behaviors Related to Psychiatric Disorders and Pain Perception in C57BL/6J Mice During Different Phases of Estrous Cycle

Frontiers in Neuroscience, 2021
Robust sex difference among humans regarding psychiatry- and pain-related behaviors is being researched; however, the use of female mice in preclinical research is relatively rare due to an unchecked potential behavioral variation over the estrous cycle.
Weinan Zhao, Weinan Zhao, Weinan Zhao, Qing Li, Qing Li, Qing Li, Qing Li, Qing Li, Qing Li, Yu Ma, Yu Ma, Yu Ma, Zhiyong Wang, Zhiyong Wang, Zhiyong Wang, Bingqian Fan, Bingqian Fan, Bingqian Fan, Xiaojing Zhai, Xiaojing Zhai, Xiaojing Zhai, Mengfan Hu, Mengfan Hu, Mengfan Hu, Mengfan Hu, Qing Wang, Qing Wang, Qing Wang, Qing Wang, Moruo Zhang, Moruo Zhang, Moruo Zhang, Moruo Zhang, Chunyan Zhang, Chunyan Zhang, Chunyan Zhang, Chunyan Zhang, Yixue Qin, Yixue Qin, Yixue Qin, Yixue Qin, Sha Sha, Sha Sha, Sha Sha, Sha Sha, Zhonghao Gan, Zhonghao Gan, Zhonghao Gan, Zhonghao Gan, Fan Ye, Yihan Xia, Guangchao Zhang, Guangchao Zhang, Guangchao Zhang, Li Yang, Li Yang, Li Yang, Shiya Zou, Shiya Zou, Shiya Zou, Zheng Xu, Zheng Xu, Zheng Xu, Sunhui Xia, Sunhui Xia, Sunhui Xia, Yumei Yu, Yumei Yu, Yumei Yu, Mannan Abdul, Mannan Abdul, Mannan Abdul, Mannan Abdul, Jun-Xia Yang, Jun-Xia Yang, Jun-Xia Yang, Jun-Li Cao, Jun-Li Cao, Jun-Li Cao, Jun-Li Cao, Fang Zhou, Hongxing Zhang, Hongxing Zhang, Hongxing Zhang   +83 more
doaj   +1 more source

The PrLGlu→avBNSTGABA circuit rapidly modulates depression-like behaviors in male mice

iScience, 2023
Summary: Depression is a global disease with a high prevalence. Here, we examine the role of the circuit from prelimbic mPFC (PrL) to the anterior ventral bed nucleus of the stria terminalis (avBNST) in depression-like mice through behavioral tests ...
Jie-ying Chen, Ke Wu, Miao-miao Guo, Wei Song, Si-ting Huang, Yong-mei Zhang   +5 more
doaj   +1 more source

Microglia-derived TNF-α inhibiting GABAergic neurons in the anterior lateral bed nucleus of the stria terminalis precipitates visceral hypersensitivity induced by colorectal distension in rats

Neurobiology of Stress, 2022
Irritable bowel syndrome (IBS) is a common and debilitating gastrointestinal disorder that is exacerbated by stress and characterized by abdominal pain.
Ning-Ning Ji, Qing-Xiang Meng, Ying Wang, Zi-Ming Zhou, Yu Song, Rong Hua, Yong-Mei Zhang   +6 more
doaj   +1 more source

Precursors and Chemicals Frequently Used in the Illicit Manufacture of Narcotic Drugs and Psychotropic Substances

Precursors and Chemicals Frequently Used in the Illicit Manufacture of Narcotic Drugs and Psychotropic Substances, 2019
The updated lists of substances under international control, comprising narcotic drugs, psychotropic substances and substances frequently used in the illicit manufacture of narcotic drugs and psychotropic substances, are contained in the latest editions ...
In Memoriam, H. Ghodse
semanticscholar   +1 more source

[Overdose deaths from narcotic drugs and psychotropic substances in Russia (an analysis of materials for the period 2003 to 2018)].

Sudebno-meditsinskaia ekspertiza, 2019
The purpose of the work is to study the prevalence of overdose deaths from narcotic drugs and psychotropic substances in Russia, as determined by forensic autopsies, for the period 2003 to 2018.
V. Vladimirov, A. V. Kovalev, P. V. Minaeva, O. V. Samokhodskaya   +3 more
semanticscholar   +1 more source

Aberrant expression of FBXO22 is associated with propofol-induced synaptic plasticity and cognitive dysfunction in adult mice

Frontiers in Aging Neuroscience, 2022
Recent observation demonstrated that prolonged anesthesia modifies brain synaptic architecture in all ages, including adult. Propofol is the most commonly utilized anesthetics at clinic.
Xiaoxuan Yang, Chen Chen, Chen Chen, Dongmei Qu, Yanping Liu, Yanping Liu, Ning Wang, Ning Wang, Haibi Wang, Haibi Wang, Youjia Fan, Yushan Zhou, Buwei Yu, Qingsheng Xue, Yuqing Wu, Yuqing Wu, Han Lu   +16 more
doaj   +1 more source

Protocol to study projection-specific circuits in the basal ganglia of adult mice using viral vector tracing, optogenetics, and patch-clamp technique

STAR Protocols, 2023
Summary: Analysis of synaptic strength and plasticity provides functional insights of complicated neural circuits. Here, we describe steps for cell- and projection-specific optogenetic manipulation of divergent basal ganglia circuits using anterograde ...
Ya-Wei Ji, Xiang-Ying Xu, Cui Yin, Chunyi Zhou, Cheng Xiao   +4 more
doaj   +1 more source

Systematic Literature Review of Spinal Cord Stimulation in Patients With Chronic Back Pain Without Prior Spine Surgery

Neuromodulation: Technology at the Neural Interface, EarlyView., 2021
Abstract Objective Low back pain is the leading cause of disability worldwide and one of the most common reasons for seeking healthcare. Despite numerous care strategies, patients with low back pain continue to exhibit poor outcomes. Spinal cord stimulation (SCS) is an evidence‐based therapeutic modality for patients with failed back surgery syndrome ...
Jan M. Eckermann, Julie G. Pilitsis, Christopher Vannaboutathong, Belinda J. Wagner, Rose Province‐Azalde, Markus A. Bendel   +5 more
wiley   +1 more source

Adjudication and Treatment of Narcotic Drug Offenders in Ghana

The Journal of Medicine, Law & Public Health, 2023
Narcotic drug trafficking is a criminal and punishable offence in every country the world over. The use of certain narcotic drugs, on the other hand (especially marijuana), has been legalised in some countries, but under strict regulations.
Jacob Agboli
doaj   +1 more source