Results 1 to 10 of about 39,014 (227)

Evaluation of spasmolytic effects of naringenin on ileum contraction and intestinal charcoal meal transit: Involvement of ATP-sensitive K+ channels [PDF]

Journal of HerbMed Pharmacology, 2022
Introduction: Naringenin is a flavonoid constituent of many herbal plants, including citreous fruits. Biological studies have suggested various therapeutic effects for naringenin, including protective effects on gastrointestinal (GI) motility.
Hassan Sadraei, Maedeh Ghasemi, Salman Saranji   +2 more
doaj   +1 more source

Polymeric Forms of Plant Flavonoids Obtained by Enzymatic Reactions

Molecules, 2022
Naringenin is one of the flavonoids originating from citrus fruit. This polyphenol is mainly found in grapefruit, orange and lemon. The antioxidant and antimicrobial properties of flavonoids depend on their structure, including the polymeric form.
Malgorzata Latos-Brozio, Anna Masek, Małgorzata Piotrowska   +2 more
doaj   +1 more source

Naringenin inhibits lipid accumulation by activating the AMPK pathway in vivo and vitro

Food Science and Human Wellness, 2023
The aim of this study was to explore the lipid-lowering effect of naringenin and the underlying mechanism in high-fat-diet-fed SD rats and 3T3-L1 cells. In this study, SD rats were divided into the normal chow diet group (NCD), high fat diet group (HFD),
Xiaoyu Cai, Songxue Wang, Huali Wang, Suwen Liu, Guishan Liu, Huibin Chen, Ji Kang, Hao Wang   +7 more
doaj   +1 more source

Optimum flux rerouting for efficient production of naringenin from acetate in engineered Escherichia coli

Biotechnology for Biofuels and Bioproducts, 2022
Background Microbial production of naringenin has received much attention owing to its pharmaceutical applicability and potential as a key molecular scaffold for various flavonoids.
Dong Hwan Kim, Hyun Gyu Hwang, Gyoo Yeol Jung   +2 more
doaj   +1 more source

Naringenin Induces HepG2 Cell Apoptosis via ROS-Mediated JAK-2/STAT-3 Signaling Pathways

Molecules, 2023
Hepatocarcinoma is one of the most prevalent digestive system tumors worldwide and lacks effective therapy. Recently, naringenin has been isolated from some citrus fruits, and its anticancer effects have been tested.
Ming Zhang, Jianmei Lai, Qianlong Wu, Jia Lai, Jingyao Su, Bing Zhu, Yinghua Li   +6 more
doaj   +1 more source

Naringenin ameliorates collagen‐induced arthritis through activating AMPK‐mediated autophagy in macrophages

Immunity, Inflammation and Disease, 2023
Background Naringenin is widely recognized for its notable attributes, including anti‐inflammatory, anti‐cancer, and immunomodulatory activities. However, its specific implications for rheumatoid arthritis (RA) and the underlying mechanisms remain to be ...
Wei Zhang, Yuan Zhang, Jianguang Zhang, Chunbiao Deng, Chao Zhang   +4 more
doaj   +1 more source

Characterization, in Vitro and in Vivo Evaluation of Naringenin-Hydroxypropyl-β-Cyclodextrin Inclusion for Pulmonary Delivery

Molecules, 2020
Naringenin, a flavonoid compound which exists abundantly in Citrus fruits, is proven to possess excellent antitussive and expectorant effects. However, the clinical applications of naringenin are restricted by its poor solubility and low local ...
Minyi Guan, Rui Shi, Yuying Zheng, Xuan Zeng, Weiyang Fan, Yonggang Wang, Weiwei Su   +6 more
doaj   +1 more source

Integrated network pharmacology and experimental validation to explore the mechanisms underlying naringenin treatment of chronic wounds

Scientific Reports, 2023
Naringenin is a citrus flavonoid with various biological functions and a potential therapeutic agent for skin diseases, such as UV radiation and atopic dermatitis.
Rui Sun, Chunyan Liu, Jian Liu, Siyuan Yin, Ru Song, Jiaxu Ma, Guoqi Cao, Yongpan Lu, Guang Zhang, Zhenjie Wu, Aoyu Chen, Yibing Wang   +11 more
doaj   +1 more source

Grapefruit Flavonoid Naringenin Sex-Dependently Modulates Action Potential in an In Silico Human Ventricular Cardiomyocyte Model

Antioxidants, 2022
Recent in vitro studies showed that grapefruit (Citrus × paradisi) flavonoid naringenin alters the function of cardiac ion channels. Here, we explored the effect of naringenin on cardiomyocyte action potentials (APs) using a detailed in silico model of ...
Henry Sutanto, Decsa Medika Hertanto, Hendri Susilo, Citrawati Dyah Kencono Wungu   +3 more
doaj   +1 more source

Protective Effects of Naringenin and Apigenin in Ameliorating Skin Damage via Mediating the Nrf2 and NF-κB Pathways in Mice

Foods, 2023
Naringenin and apigenin are common flavonoids derived from edible plants with the potential to alleviate inflammation and improve skin antioxidation. This study aimed to evaluate the effects of naringenin and apigenin on oleic acid-induced skin damage in
Jie Li, Bingyong Mao, Xin Tang, Qiuxiang Zhang, Jianxin Zhao, Hao Zhang, Shumao Cui   +6 more
doaj   +1 more source