Results 1 to 10 of about 2,438,240 (230)

Different Methods and Formulations of Drugs and Vaccines for Nasal Administration

Pharmaceutics, 2022
Nasal drug delivery is advantageous when compared with other routes of drug delivery as it avoids the hepatic first-pass effect, blood–brain barrier penetration, and compliance issues with parenteral administration. However, nasal administration also has
Junhu Tai, Munsoo Han, Dabin Lee, Il-Ho Park, Sang Hag Lee, Tae Hoon Kim   +5 more
doaj   +2 more sources

Spray Freeze Dried Lyospheres® for Nasal Administration of Insulin [PDF]

Pharmaceutics, 2021
Pharmacologically active macromolecules, such as peptides, are still a major challenge in terms of designing a delivery system for their transport across absorption barriers and at the same time provide sufficiently high long-term stability. Spray freeze dried (SFD) lyospheres® are proposed here as an alternative for the preparation of fast dissolving ...
Tuğrul Mert Serim, Jan Kožák, Annika Rautenberg, Ayşe Nurten Özdemir, Yann Pellequer, Alf Lamprecht   +5 more
openaire   +4 more sources

Research progress in brain-targeted nasal drug delivery

Frontiers in Aging Neuroscience
The unique anatomical and physiological connections between the nasal cavity and brain provide a pathway for bypassing the blood–brain barrier to allow for direct brain-targeted drug delivery through nasal administration.
Qingqing Huang, Qingqing Huang, Xin Chen, Sixun Yu, Gu Gong, Haifeng Shu, Haifeng Shu   +6 more
doaj   +2 more sources

Opportunities and challenges for the nasal administration of nanoemulsions [PDF]

Current Topics in Medicinal Chemistry, 2015
© 2015 Bentham Science Publishers. Nasal delivery has become a growing area of interest for drug administration as a consequence of several practical advantages, such as ease of administration and non-invasiveness.
Comfort, C, Garrastazu, G, Pozzoli, M, Sonvico, F   +3 more
core   +2 more sources

Development of Nanocomposite Microspheres for Nasal Administration of Deferiprone in Neurodegenerative Disorders

Journal of Functional Biomaterials
Elevated brain iron levels are characteristic of many neurodegenerative diseases. As an iron chelator with short biological half-life, deferiprone leads to agranulocytosis and neutropenia with a prolonged therapeutic course.
Radka Boyuklieva, Plamen Katsarov, Plamen Zagorchev, Silviya Abarova, Asya Hristozova, Bissera Pilicheva   +5 more
doaj   +2 more sources

Clonidine in pediatric anesthesia : aspects on population pharmacokinetics, nasal administration and safety [PDF]

, 2014
Clonidine is widely use as premedication in pediatric patients and has many beneficial effects in the perioperative period. The introduction of population pharmacokinetics in the 1980s has proven useful when performing pharmacokinetic studies in ...
Larsson, Peter
core   +2 more sources

Administration of nasal medications to infants and young children – thematic analysis of parents’ experiences in online forum discussions and blogs [PDF]

, 2015
Background: Allergic rhinitis is an increasing problem among children in developed countries. A 12-year birth cohort study from 2001 to 2012 on Isle of Wight showed that current-rhinitis and lifetime-rhinitis prevalence increased by 5.5% (22.6-vs-28.1,
Bulbul, Alpaslan, Jones, Christina, Mukhopadhyay, Somnath, Smith, Helen   +3 more
core   +1 more source

Nasal Administration of a Nanoemulsion Based on Methyl Ferulate and Eugenol Encapsulated in Chitosan Oleate: Uptake Studies in the Central Nervous System [PDF]

Pharmaceutics
Background/Objectives: The phytochemicals ferulic acid (Fer) and eugenol display neuroprotective effects for their anti-oxidative properties; moreover, eugenol can induce dopamine (DA) release from dopaminergic neuronal cells.
Giada Botti, Laura Catenacci, Alessandro Dalpiaz, Luca Randi, Maria Cristina Bonferoni, Sara Perteghella, Sarah Beggiato, Luca Ferraro, Barbara Pavan, Milena Sorrenti   +9 more
doaj   +2 more sources

Reduced Sodium Transport With Nasal Administration of the Prostasin Inhibitor Camostat in Subjects With Cystic Fibrosis [PDF]

Chest, 2013
Steven M. Rowe, Ginger Reeves, Heather Hathorne, G. Martin Solomon, Smita Abbi, Didier Renard, Ruth Lock, Ping Zhou, Henry Danahay, John Clancy, David Waltz   +10 more
openalex   +2 more sources

Nasal administration of anti-CD3 mAb (Foralumab) downregulates NKG7 and increases TGFB1 and GIMAP7 expression in T cells in subjects with COVID-19

Proceedings of the National Academy of Sciences of the United States of America, 2023
Significance Activated T cells play an important role in the complications following COVID-19 infection. Anti-CD3 monoclonal antibody (mAb) binds to the T cell receptor and dampens inflammation by modulating T cell function.
Thais G Moreira, C. Gauthier, Liam Murphy, Toby B Lanser, A. Paul, K. Matos, D. Mangani, Saef Izzy, R. Rezende, B. Healy, C. Baecher-Allan, T. Chitnis, Vijay Kuchroo, H. Weiner   +13 more
semanticscholar   +1 more source