Results 11 to 20 of about 2,438,339 (329)
Pharmaceuticals, 2021 The nasal route has been used for many years for the local treatment of nasal diseases. More recently, this route has been gaining momentum, due to the possibility of targeting the central nervous system (CNS) from the nasal cavity, avoiding the blood ...
Cláudia Pina Costa +6 more
doaj +1 more source
ED95 of remimazolam in nasal administration for attenuating preoperative anxiety in children
Frontiers in Medicine, 2023 Background Preoperative anxiety often prevails in children at higher levels than adults, which is a common impediment for surgeons and anesthesiologists. It is of great necessity to explore an appropriate medication to improve this situation. Remimazolam,
Xiang Long +6 more
semanticscholar +1 more source
Frontiers in Immunology, 2021 Respiratory syncytial virus (RSV) is a public health concern that causes acute lower respiratory tract infection. So far, no vaccine candidate under development has reached the market and the only licensed product to prevent RSV infection in at-risk ...
Emilie Jacque +16 more
doaj +1 more source
Nasal administration of mitochondria reverses chemotherapy-induced cognitive deficits
Theranostics, 2021 Up to seventy-five percent of patients treated for cancer suffer from cognitive deficits which can persist for months to decades, severely impairing quality of life.
J. Alexander +9 more
semanticscholar +1 more source
Clinical and Experimental Allergy, 2022 Topical probiotics have been suggested as a treatment option for allergic rhinitis, as they may skew the immune response towards a beneficial type‐1 non‐allergic profile. So far observations in man have exclusively involved oral intake.
Anders Mårtensson +6 more
semanticscholar +1 more source
Gels, 2022 Alzheimer’s disease is characterized by a progressive deterioration of neurons resulting in a steady loss of cognitive functions and memory. Many treatments encounter the challenge of overcoming the blood–brain barrier, thus the intranasal route is a non-
L. Espinoza +7 more
semanticscholar +1 more source
Targeting Systems to the Brain Obtained by Merging Prodrugs, Nanoparticles, and Nasal Administration
Pharmaceutics, 2021 About 40 years ago the lipidization of hydrophilic drugs was proposed to induce their brain targeting by transforming them into lipophilic prodrugs.
Giada Botti, A. Dalpiaz, B. Pavan
semanticscholar +1 more source
Comparison of Modern In Vitro Permeability Methods with the Aim of Investigation Nasal Dosage Forms
Pharmaceutics, 2021 Nowadays, the intranasal route has become a reliable alternative route for drug administration to the systemic circulation or central nervous system. However, there are no official in vitro diffusion and dissolution tests especially for the investigation
Csilla Bartos +4 more
doaj +1 more source
Molecules, 2022 Ischemic stroke is a difficult-to-treat brain disease that may be attributed to a limited therapeutic time window and lack of effective clinical drugs. Nasal–brain administration is characterized by low systemic toxicity and is a direct and non-invasive ...
Chunhui Huang +10 more
doaj +1 more source
Hyaluronic acid: perspectives in upper aero-digestive tract. A systematic review [PDF]
, 2015 Background: To date, topical therapies guarantee a better delivery of high concentrations of pharmacologic agents to the mucosa of the upper aerodigestive tract (UADT).
Baptista, Peter +7 more
core +14 more sources