Results 61 to 70 of about 15,447 (234)

Straight to Phase III: Model‐Informed Approach Speeds Depemokimab Clinical Development in Interleukin‐5‐Driven Diseases

Clinical Pharmacology &Therapeutics, EarlyView.
Straight to Phase III: Model‐informed approach speeds depemokimab clinical development in interleukin‐5‐driven diseases. IL‐5, a key mediator of type 2 inflammation, underlies various diseases, including severe asthma, CRSwNP, EGPA, and HES. Reduction in blood eosinophil count (BEC), a biomarker of IL‐5 activity, is commonly used to evaluate the ...
Chiara Zecchin, Stein Schalkwijk, Isabelle J. Pouliquen, Alienor Berges, Nicholas Bird, Richard Follows, Daren Austin   +6 more
wiley   +1 more source

Agreement Rate of Skin Prick Test with Tissue Eosinophil Count in Patients with Nasal Polyps

Iranian Journal of Allergy, Asthma and Immunology, 2007
The pathogenetic mechanism of nasal polyps remains unknown, although allergy has been cited as an important factor in the etiology of nasal polyposis. Currently there is no definite histological criterion for differentiation of allergic from inflammatory
Fardin Eghtedari, Seyed Reza Cheraghzadeh, Mohammad Amin Kashef, Ahmad Monabati, Sara Kashef   +4 more
doaj  

Surmounting Recalcitrant Airway Inflammatory Disorders With a Multi‐Targeting Therapeutic Strategy by Tannic Acid‐Modified CuInP2S6 Nanosheets

Exploration, EarlyView.
Our findings underscore a multi‐targeting strategy for severe airway inflammation that multi‐targeting nanoformulation C‐TA1 markedly attenuated airway inflammation by (1) cfDNA elimination to alleviate neutrophilic/eosinophilic inflammation mediated by the TLR9 pathway, (2) prevention of RONS‐induced tissue injury and inflammatory response, (3 ...
Ming Liu, Changyi Xu, Renqiang Ma, Xinran Xie, Ying Xie, Mengya Du, Zhaofeng Xu, Shuaiyin Zhang, Jian Li, Weiping Wen, Zhaoxu Tu   +10 more
wiley   +1 more source

Stratification of chronic rhinosinusitis with nasal polyps by distinct sinonasal microbial communities and their clinical and pathological correlations

iMetaOmics, EarlyView.
Chronic rhinosinusitis with nasal polyps (CRSwNP) is a heterogeneous inflammatory condition. Dysbiosis is commonly observed. This study identified distinct sinonasal microbial communities in CRSwNP patients and explored their clinical and pathological associations. Two distinct microbial communities were identified: community type 1 (CT1), dominated by
Bixing Fang, Yanmin Liu, Qing Bao, Lin Sun, Hexin Chen, Qingxiang Meng, Linyi Jiao, Xiaoyan Ye, Jian Li, Tao Ding, Chunwei Li   +10 more
wiley   +1 more source

Vitamin D decreases the secretion of matrix metalloproteinase-2 and matrix metalloproteinase-9 in fibroblasts derived from Taiwanese patients with chronic rhinosinusitis with nasal polyposis

Kaohsiung Journal of Medical Sciences, 2015
Vitamin D and its derivatives have modulatory effects in immunological and inflammatory responses. Such properties suggest that they might have an impact on chronic inflammatory airway diseases, including nasal polyposis.
Ling-Feng Wang, Chih-Feng Tai, Chen-Yu Chien, Feng-Yu Chiang, Jeff Yi-Fu Chen   +4 more
doaj   +1 more source

Dupilumab as an effective therapy for eosinophilic esophagitis in pediatric patients weighing less than 15 kilograms

JPGN Reports, EarlyView.
Abstract Objectives Eosinophilic esophagitis (EoE) is a type 2 cytokine‐mediated chronic inflammatory condition leading to esophageal dysfunction. Dupilumab blocks IL‐4 and IL‐13 signaling, which are key inflammatory mediators in EoE and other allergic disorders.
Sindhura Kasturi, Tanaz Danialifar, Thirumazhisai Gunasekaran, Nick Shillingford, Paul Zamiara, Vrinda Bhardwaj, Melinda Braskett   +6 more
wiley   +1 more source

Menetrier's: A pediatric chronic state of disease with a possible heritable form

JPGN Reports, EarlyView.
Abstract Menetrier's disease (MD) is a rare, typically transient, hypertrophic gastropathy with under 1000 adult cases and 50 pediatric cases known worldwide. Pediatric cases most often present with an infectious etiology. We present a case of a teenage male expressing a chronic state of disease without infectious origin.
MariaElena Terzis, Anna Furr, Julia Fritz   +2 more
wiley   +1 more source

The Role of Artificial Intelligence in Modern Allergology: A Review of Applications in Diagnosis, Prediction, and Management

JEADV Clinical Practice, EarlyView.
ABSTRACT Artificial Intelligence is rapidly transforming allergology by enhancing diagnosis, risk prediction, automation, patient communication, education, and therapy development. Machine learning approaches, including convolutional neural networks, recurrent architectures, and transformer‐based models, enable analysis of complex datasets from ...
Sebastian Seurig, Stephan Traidl, Sonja Mathes   +2 more
wiley   +1 more source

Dupilumab‐Related Adverse Events and Intolerance in Aspirin‐Exacerbated Respiratory Disease Patients

International Forum of Allergy &Rhinology, EarlyView.
Lancelot P. Herpin, Randy Bach, Ricardo Bruneto, Kerol A. Faltas, Michael A. Kohanski, James N. Palmer, Nithin D. Adappa, Jennifer E. Douglas, John V. Bosso   +8 more
wiley   +1 more source

Elexacaftor–Tezacaftor–Ivacaftor Reduces Revision Sinus Surgery in People With Cystic Fibrosis

The Laryngoscope, EarlyView.
Elexacaftor–tezacaftor–ivacaftor (ETI) was associated with a significant decrease in the frequency and rate of endoscopic sinus surgeries in patients with cystic fibrosis. These findings suggest an improvement in CF‐related chronic rhinosinusitis outcomes following ETI and may influence future CF treatment decisions.
Amy Lin, Makanko Komara, Isaac Kistler, Zheng Hong Tan, Meredith Lind, Kavitha Kotha, Tendy Chiang   +6 more
wiley   +1 more source