Results 1 to 10 of about 1,451,429 (415)

TRIM21 inhibits irradiation-induced mitochondrial DNA release and impairs antitumour immunity in nasopharyngeal carcinoma tumour models

Nature Communications, 2023
The molecular mechanisms determining the response to radiotherapy remain incompletely understood. Here, the authors demonstrate that the E3 ubiquitin ligase and intracellular Fc receptor, TRIM21, impairs CD8+ T cell responses in nasopharyngeal carcinoma ...
Jun-Yan Li, Yin Zhao, Sha Gong, Miao-Miao Wang, Xu Liu, Qing-Mei He, Ying-Qin Li, Sheng-Yan Huang, Han Qiao, Xi-Rong Tan, Ming-Liang Ye, Xun-Hua Zhu, Shi-Wei He, Qian Li, Ye-Lin Liang, Kai-Lin Chen, Sai-Wei Huang, Qing-Jie Li, Jun Ma, Na Liu   +19 more
doaj   +2 more sources

Effect and safety of immunotherapy among elder patients (age ≥ 65) with recurrent or metastatic nasopharyngeal carcinoma [PDF]

BMC Cancer
Background The use of immune checkpoint inhibitors (ICIs) combined with chemotherapy constitutes the first-line treatment for recurrent or metastatic nasopharyngeal carcinoma (RM-NPC).
Rui-Ling Xie, Wu-Lin Cai, Yan-Feng Ouyang, Ye-Hao Zou, Rui Sun   +4 more
doaj   +2 more sources

Nasopharyngeal carcinoma cells promote regulatory T cell development and suppressive activity via CD70-CD27 interaction

Nature Communications, 2023
Despite the intense CD8+ T-cell infiltration in the tumor microenvironment of nasopharyngeal carcinoma, anti-PD-1 immunotherapy shows an unsatisfactory response rate in clinical trials, hindered by immunosuppressive signals.
Lanqi Gong, Jie Luo, Yu Zhang, Yu-Ma Yang, Shan-Shan Li, Xiaona Fang, Baifeng Zhang, Jiao-Ren Huang, Larry Ka-Yue Chow, D. Chung, Jinlin Huang, Cuicui Huang, Qin Liu, Lu Bai, Yuen Chak Tiu, Pingan Wu, Yan Wang, G. Tsao, D. Kwong, A. Lee, W. Dai, X. Guan   +21 more
semanticscholar   +1 more source

Clinical advances in nasopharyngeal carcinoma surgery and a video demonstration

Visualized Cancer Medicine, 2021
Nasopharyngeal carcinoma (NPC) is highly radiosensitive, and radiotherapy is recommended for newly diagnosed NPC. Because of the poor visual surgical field, narrow operating space, difficulty protecting the internal carotid artery (ICA) and poor wound ...
Ding Xi, Liu You-Ping, Hua Yi-Jun, Zou Xiong, Wang Zhi-Qiang, Xie Yu-Long, Chen Ming-Yuan   +6 more
doaj   +1 more source

Association of Intratumoral Microbiota With Prognosis in Patients With Nasopharyngeal Carcinoma From 2 Hospitals in China

JAMA Oncology, 2022
Key Points Question Is there characteristic microbiota in nasopharyngeal carcinoma (NPC) tissues and, if so, is it associated with prognosis? Findings In this multicenter cohort study including 802 patients with NPC, we confirmed the existence of ...
Han Qiao, Xirong Tan, Hui Li, Junyan Li, Xiaozhong Chen, Yingqin Li, Wen-Fei Li, L. Tang, G. Zhou, Yuan Zhang, Yelin Liang, Qingmei He, Yin Zhao, Shengyan Huang, Sha Gong, Qian Li, Mingxia Ye, Kailin Chen, Ying Sun, Jun Ma, Na Liu   +20 more
semanticscholar   +1 more source

The Evolving Epidemiology of Nasopharyngeal Carcinoma

Cancer Epidemiology, Biomarkers and Prevention, 2021
Background: The epidemiology of nasopharyngeal carcinoma (NPC) has long been a source of fascination due to the malignancy's striking geographic distribution, the involvement of the oncogenic Epstein–Barr virus (EBV), the unique association with intake ...
E. Chang, W. Ye, Y. Zeng, H. Adami
semanticscholar   +1 more source

The Chinese Society of Clinical Oncology (CSCO) clinical guidelines for the diagnosis and treatment of nasopharyngeal carcinoma

Cancer Communications, 2021
Nasopharyngeal carcinoma (NPC) is a malignant epithelial tumor originating in the nasopharynx and has a high incidence in Southeast Asia and North Africa.
L. Tang, Yupei Chen, Chuanben Chen, Ming-Yuan Chen, N. Chen, Xiaozhong Chen, Xiao-jing Du, W. Fang, M. Feng, Jin Gao, F. Han, Xia He, Chaosu Hu, Denghua Hu, G. Hu, Hao Jiang, Wei Jiang, F. Jin, J. Lang, Jin-Gao Li, Shaojun Lin, Xu Liu, Qiuhua Liu, Lin Ma, H. Mai, Jiyong Qin, Liangfang Shen, Ying Sun, Pei-guo Wang, Ren-Sheng Wang, Ruo-Zheng Wang, Xiaoshen Wang, Ying Wang, Huifang Wu, Yun-Fei Xia, S. Xiao, Kun-yu Yang, J. Yi, Xiao-dong Zhu, Jun Ma   +39 more
semanticscholar   +1 more source

Targeting hypoxia-inducible factor-1α (HIF-1α) in combination with antiangiogenic therapy: a phase I trial of bortezomib plus bevacizumab. [PDF]

, 2014
PurposeWe hypothesized that bortezomib, an agent that suppresses HIF-1α transcriptional activity, when combined with bevacizumab, would obviate the HIF-1α resistance pathway.
Amin, Hesham M, Angelo, Laura S, Falchook, Gerald S, Hess, Kenneth, Hong, David, Howard, Adrienne N, Huang, Mei, Jackson, Edward F, Janku, Filip, Kurzrock, Razelle, Lawhorn, Kristie N, Naing, Aung, Ng, Chaan S, Parkhurst, Kristin L, Tannir, Nizar M, Vishwamitra, Deeksha, Wheler, Jennifer J   +16 more
core   +9 more sources

The role of the bacterial microbiome in the treatment of cancer

BMC Cancer, 2021
The human microbiome is defined as the microorganisms that reside in or on the human body, such as bacteria, viruses, fungi, and protozoa, and their genomes.
Zi-Kun Yu, Rui-Ling Xie, Rui You, You-Ping Liu, Xu-Yin Chen, Ming-Yuan Chen, Pei-Yu Huang   +6 more
doaj   +1 more source

Tumour heterogeneity and intercellular networks of nasopharyngeal carcinoma at single cell resolution

Nature Communications, 2021
The heterogeneous nature of tumour microenvironment (TME) underlying diverse treatment responses remains unclear in nasopharyngeal carcinoma (NPC). Here, we profile 176,447 cells from 10 NPC tumour-blood pairs, using single-cell transcriptome coupled ...
Yang Liu, Shuai He, Xiliang Wang, W. Peng, Qiu-Yan Chen, Dong-Mei Chi, Jie-Rong Chen, Bo W. Han, G. Lin, Yi-Qi Li, Qian-Yu Wang, Roujun Peng, Pan-Pan Wei, Xiang Guo, Bo Li, Xiaojun Xia, H. Mai, Xue-Da Hu, Zemin Zhang, Y. Zeng, J. Bei   +20 more
semanticscholar   +1 more source