Results 1 to 10 of about 370,367 (299)

Heterocyclic Iminoquinones and Quinones from the National Cancer Institute (NCI, USA) COMPARE Analysis [PDF]

Molecules, 2023
This review uses the National Cancer Institute (NCI) COMPARE program to establish an extensive list of heterocyclic iminoquinones and quinones with similarities in differential growth inhibition patterns across the 60-cell line panel of the NCI ...
Naemah Haji, Masoma Faizi, Panayiotis A. Koutentis, Michael P. Carty, Fawaz Aldabbagh   +4 more
doaj   +4 more sources

Profiling mRNA, miRNA and lncRNA expression changes in endothelial cells in response to increasing doses of ionizing radiation

Scientific Reports, 2022
Recent and past research have highlighted the importance of the endothelium in the manifestation of radiation injury. Our primary focus is on medical triage and management following whole body or partial-body irradiation.
Sunita Chopra, Uma Shankavaram, Michelle Bylicky, Juan Dalo, Kevin Scott, Molykutty J. Aryankalayil, C. Norman Coleman   +6 more
doaj   +1 more source

Cancer cell survival depends on collagen uptake into tumor-associated stroma

Nature Communications, 2022
Collagen can be a metabolic source to fuel cancer growth. Here the authors show that cell surface protein TEM8 mediates the binding and uptake of collagen in stromal cells and these cells processed the collagen to glutamine, providing an alternative ...
Kuo-Sheng Hsu, James M. Dunleavey, Christopher Szot, Liping Yang, Mary Beth Hilton, Karen Morris, Steven Seaman, Yang Feng, Emily M. Lutz, Robert Koogle, Francesco Tomassoni-Ardori, Saurabh Saha, Xiaoyan M. Zhang, Enrique Zudaire, Pradip Bajgain, Joshua Rose, Zhongyu Zhu, Dimiter S. Dimitrov, Frank Cuttitta, Nancy J. Emenaker, Lino Tessarollo, Brad St. Croix   +21 more
doaj   +1 more source

Whole blood gene expression within days after total-body irradiation predicts long term survival in Gottingen minipigs

Scientific Reports, 2021
Gottingen minipigs mirror the physiological radiation response observed in humans and hence make an ideal candidate model for studying radiation biodosimetry for both limited-sized and mass casualty incidents.
Sunita Chopra, Maria Moroni, Jaleal Sanjak, Laurel MacMillan, Bernadette Hritzo, Shannon Martello, Michelle Bylicky, Jared May, C. Norman Coleman, Molykutty J. Aryankalayil   +9 more
doaj   +1 more source

Circulating trans fatty acids are associated with prostate cancer in Ghanaian and American men

Nature Communications, 2023
The association between fatty acids and prostate cancer remains poorly explored in African-descent populations. Here, we analyze 24 circulating fatty acids in 2934 men, including 1431 prostate cancer cases and 1503 population controls from Ghana and the ...
Tsion Zewdu Minas, Brittany D. Lord, Amy L. Zhang, Julián Candia, Tiffany H. Dorsey, Francine S. Baker, Wei Tang, Maeve Bailey-Whyte, Cheryl J. Smith, Obadi M. Obadi, Anuoluwapo Ajao, Symone V. Jordan, Yao Tettey, Richard B. Biritwum, Andrew A. Adjei, James E. Mensah, Robert N. Hoover, Ann W. Hsing, Jia Liu, Christopher A. Loffredo, Clayton Yates, Michael B. Cook, Stefan Ambs   +22 more
doaj   +1 more source

GWAS Explorer: an open-source tool to explore, visualize, and access GWAS summary statistics in the PLCO Atlas

Scientific Data, 2023
The Prostate, Lung, Colorectal and Ovarian (PLCO) Cancer Screening Trial is a prospective cohort study of nearly 155,000 U.S. volunteers aged 55–74 at enrollment in 1993–2001.
Mitchell J. Machiela, Wen-Yi Huang, Wendy Wong, Sonja I. Berndt, Joshua Sampson, Jonas De Almeida, Mustapha Abubakar, Jada Hislop, Kai-Ling Chen, Casey Dagnall, Norma Diaz-Mayoral, Mary Ferrell, Michael Furr, Alex Gonzalez, Belynda Hicks, Aubrey K. Hubbard, Amy Hutchinson, Kevin Jiang, Kristine Jones, Jia Liu, Erikka Loftfield, Jennifer Loukissas, Jerome Mabie, Shannon Merkle, Eric Miller, Lori M. Minasian, Ellen Nordgren, Brian Park, Paul Pinsky, Thomas Riley, Lorena Sandoval, Neeraj Saxena, Aurelie Vogt, Jiahui Wang, Craig Williams, Patrick Wright, Meredith Yeager, Bin Zhu, Claire Zhu, Stephen J. Chanock, Montserrat Garcia-Closas, Neal D. Freedman   +41 more
doaj   +1 more source

Enrollment of adolescents and young adults onto SWOG cancer research network clinical trials: A comparative analysis by treatment site and era. [PDF]

, 2020
BackgroundFew adolescents and young adults (AYAs, 15-39 years old) enroll onto cancer clinical trials, which hinders research otherwise having the potential to improve outcomes in this unique population.
Blanke, Charles, Budd, Troy, Freyer, David R, Johnson, Rebecca H, Lewis, Mark A, O'Mara, Ann M, Pollock, Brad H, Roth, Michael E, Unger, Joseph M   +8 more
core   +2 more sources

Pharmacologically directed strategies in academic anticancer drug discovery based on the European NCI compounds initiative [PDF]

, 2017
Background: The European NCI compounds programme, a joint initiative of the EORTC Research Branch, Cancer Research Campaign and the US National Cancer Institute, was initiated in 1993.
A Kamb, AM Burger, Andrew D Westwell, Anne-Sophie Govaerts, AR Hanauske, Cancer Target Discovery and Development Network, CO Leong, E Boven, GG Dark, GM Tozer, Godefridus J Peters, Hans R Hendriks, HH Fiebig, HR Hendriks, I Fichtner, I Fichtner, Iduna Fichtner, IV Bijnsdorp, J Mantaj, J Plowman, JI Johnson, K Bonezzi, KD Paull, M Hollingshead, M Seckl, MG Hollingshead, MR Boyd, MR Grever, P Diana, R Schultz, RE Wittes, RM Phillips, Sally Burtles, SL Holbeck, SP Langdon, TD Bradshaw, TD Bradshaw   +36 more
core   +6 more sources

An improved method for large-scale preparation of negatively and positively supercoiled plasmid DNA [PDF]

, 2008
A rigorous understanding of the biological function of superhelical tension in cellular DNA requires the development of new tools and model systems for study.
Ausubel F.M., Debra A. Dederich, Forterre P., Funnell B.E., Marita C. Barth, Peter C. Dedon   +5 more
core   +1 more source

Optimizing cancer immunotherapy response prediction by tumor aneuploidy score and fraction of copy number alterations

npj Precision Oncology, 2023
Identifying patients that are likely to respond to cancer immunotherapy is an important, yet highly challenging clinical need. Using 3139 patients across 17 different cancer types, we comprehensively studied the ability of two common copy-number ...
Tian-Gen Chang, Yingying Cao, Eldad D. Shulman, Uri Ben-David, Alejandro A. Schäffer, Eytan Ruppin   +5 more
doaj   +1 more source