Results 91 to 100 of about 846,596 (305)

How a National Organization Works in Partnership With People Who Have Lived Experience in Mental Health Improvement Programs: Protocol for an Exploratory Case Study [PDF]

Background: This is a research proposal for a case study to explore how a national organization works in partnership with people with lived experience in national mental health improvement programs.
Carina Hibberd, Ashley Shepherd, Ciara Robertson, Robertson, Ciara, Gordon Johnston, Johnston, Gordon, Hibberd, Carina, Shepherd, Ashley   +7 more
core   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Key informant views on potential acceptability and feasibility of long-acting antiretroviral treatment for HIV in Kenya

BMC Infectious Diseases
Background In 2020, 14% of diagnosed persons living with HIV (PLWH) in Kenya were not taking antiretroviral therapy (ART), and 19% of those on ART had unsuppressed viral loads. Long-acting antiretroviral therapy (LA-ART) may increase viral suppression by
Anne Kaggiah, Catherine N. Maina, John Kinuthia, Douglas Barthold, Brett Hauber, Jacinda Tran, Jane M. Simoni, Susan M. Graham   +7 more
doaj   +1 more source

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

Molecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera, Laura Vela‐Martín, Pablo Fernández‐Navarro, José Luis López‐Lorenzo, Javier Cornago, Pilar Llamas, Eduardo Pérez‐Gómez, José Luis Marín‐Rubio, Manuel Fresno, Javier Santos, José Fernández‐Piqueras, María Villa‐Morales   +11 more
wiley   +1 more source

National assessment of the occupational safety and health workforce [PDF]

""A fundamental part of the mission of the National Institute for Occupational Safety and Health (NIOSH) is developing and supporting a new generation of occupational safety and health (OS&H) professionals, which in turn is critical to the future of ...

core  

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

National partnership agreement on Indigenous early childhood development [PDF]

, 2015
Summary This second report on the health indicators in the National Partnership Agreement on Indigenous Early Childhood Development finds areas of improvement as well as areas of concern in the health of Aboriginal and Torres Strait Islander children ...
Australian Institute of Health and Welfare
core  

Contextual inequalities in specialized dental public health care in Brazil

Brazilian Oral Research
The present study aimed to investigate the contextual inequalities of specialized public dental care (SPDC) in Brazil. The outcome was the trajectory of dental specialized production in municipalities with SPDC (from 2015 to 2017) obtained by group-based
Ana Luiza Cardoso PIRES, Francine dos Santos COSTA, Otávio Pereira D’ÁVILA, Rodrigo Varella de CARVALHO, Marcus Cristian Muniz CONDE, Marcos Britto CORREA, Flávio Fernando DEMARCO, Luiz Alexandre CHISINI   +7 more
doaj   +1 more source

Factors associated with mortality in persons co-infected with tuberculosis and HIV in Suriname: a retrospective cohort study

Revista Panamericana de Salud Pública, 2019
Objective. To identify socio-demographic and clinical factors associated with mortality among persons with tuberculosis (TB) and TB/HIV co-infection in Suriname. Methods.
Deborah Stijnberg, Eric Commiesie, Diana Marín, Ward Schrooten, Freddy Perez, Mauro Sanchez   +5 more
doaj   +1 more source

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source