Results 81 to 90 of about 32,707,685 (254)
Cancer‐associated mutations in endometriosis reframe a benign disease through molecular oncology
Molecular Oncology, EarlyView.This review aims to comprehensively analyse cancer‐associated somatic mutations (CAMs) present in endometriotic lesions, emphasizing their biological roles, spatial distribution and implications for translational applications in medicine. By contextualizing a benign state within a genomic framework, this analysis seeks to establish its value as a ...
Clarissa Mujacic +15 more
wiley +1 more source
Essential public health functions: a guide to map and measure national workforce capacity
ix, 42 p.Strengthening the capacity of the workforce delivering essential public health functions (EPHFs) is critical for achieving universal health coverage and improving preparedness for health emergencies in an increasingly complex risk environment ...
World Health Organization
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National assessment of the occupational safety and health workforce [PDF]
""A fundamental part of the mission of the National Institute for Occupational Safety and Health (NIOSH) is developing and supporting a new generation of occupational safety and health (OS&H) professionals, which in turn is critical to the future of ...
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Molecular Oncology, EarlyView.Detecting circulating tumor cells (CTCs) in blood before surgery may help predict outcomes in patients with head and neck squamous cell carcinoma (HNSCC). Here, we show when combined with tumor size and lymph node involvement from routine imaging, CTC status identifies high‐risk patients with poorer survival—offering a simple, minimally invasive tool ...
Susanne Flach +9 more
wiley +1 more source
National Healthy Worksite Program Worksite Health 101 training manual
Through the National Healthy Worksite Program (NHWP), numerous training opportunities will be provided within NHWP communities and nationally through webinar-based programs.
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About the National Center for Environmental Health (NCEH) [PDF]
In 1980, as an expression of its commitment to solving health problems related to the environment, CDC established the Center for Environmental Health (CEH) to focus on preventing disability, disease, and death due to environmental factors.
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Molecular Oncology, EarlyView.LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang +9 more
wiley +1 more source
Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer
Molecular Oncology, EarlyView.Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas +16 more
wiley +1 more source
PANoptosis in the pathogenesis of myelodysplastic syndromes
Molecular Oncology, EarlyView.PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla +4 more
wiley +1 more source
A review of programs that targeted environmental determinants of Aboriginal and Torres Strait Islander health [PDF]
, 2013 This review finds that there are relatively few papers describing interventions that target environmental determinants of Indigenous health.Abstract: Objective: Effective interventions to improve population and individual health require environmental ...
Leah Johnston
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