Results 111 to 120 of about 846,596 (305)
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Texas Residents’ Views on State and National Health Policy Priorities
, 2018 In a new survey, the Kaiser Family Foundation and the Episcopal Health Foundation sought to gauge Texans’ views on health policy priorities at both the state and national level.
Wu, Bryan +4 more
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Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source
National Cancer Institute Fact Sheet: Cancer Health Disparities
The National Cancer Institute (NCI) defines "cancer health disparities" as adverse differences in cancer incidence (new cases), cancer prevalence (all existing cases), cancer death (mortality), cancer survivorship, and burden of cancer or related health ...
National Cancer , Institute
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Administration of the Medical Specialist Training Program [PDF]
, 2015 This audit assessed the effectiveness of the Department of Health’s administration of the Medical Specialist Training Program. Audit objective and criteria The audit focused on key aspects of Health’s administration of the STP since the consolidation ...
Australian National Audit Office
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Molecular Oncology, EarlyView.Both cg12821679MAPRE3 methylation and MAPRE3 expression are significantly associated with overall survival (OS) of non‐small cell lung cancer. Meanwhile, MAPRE3 expression significantly modified the effect of smoking cessation on OS. Smoking cessation benefits OS merely for patients with high MAPRE3 expression.
Chao Chen +14 more
wiley +1 more source
Parenting in the early years: effectiveness of parenting support programs for Indigenous families [PDF]
, 2012 This resource sheet examines programs for Australian Indigenous families that effectively support parenting in the early years. This is not a systematic review of all programs; instead, it presents briefly on the evidence for parenting programs generally
Robyn Mildon, Melinda Polimeni
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BMC Health Services ResearchBackground The transition to the “test-and-treat” policy in Nepal in 2017, coupled with the rapid initiation of antiretroviral therapy (ART) in 2020, necessitates an in-depth understanding of factors influencing ART initiation and retention.
Archana Shrestha +10 more
doaj +1 more source
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Health sector decentralization and Indonesia ' s nutrition programs : opportunities and challenges [PDF]
This policy concept paper is intended to assist the center in navigating the tension between opportunities and challenges as activities are adapted to the decentralized national nutrition policy, and to help guide districts and provinces in the conduct o
Choi, Yoonjoung +4 more
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